This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: j.jacc.2006.11.046v1 49/14/1533    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Tahara, N. Articles by Imaizumi, T. Search for Related Content PubMed Articles by Tahara, N. Articles by Imaizumi, T.

CLINICAL RESEARCH: ATHEROSCLEROSIS

Vascular Inflammation Evaluated by [¹⁸F]-Fluorodeoxyglucose Positron Emission Tomography Is Associated With the Metabolic Syndrome

Nobuhiro Tahara, MD, PhD^_*,_*, Hisashi Kai, MD, PhD^_*, Sho-ichi Yamagishi, MD, PhD^_*, Minori Mizoguchi, MD^_*, Hiroyuki Nakaura, MD, PhD^_*, Masatoshi Ishibashi, MD, PhD, Hayato Kaida, MD, PhD, Kenkichi Baba, MD, Naofumi Hayabuchi, MD, PhD and Tsutomu Imaizumi, MD, PhD^_*

^_* Department of Medicine, Division of Cardio-Vascular Medicine, Kurume, Japan
Department of Radiology, Kurume University School of Medicine, Kurume, Japan.

Manuscript received August 18, 2006; revised manuscript received September 19, 2006, accepted November 19, 2006.

^_* Reprints requests and correspondence: Dr. Nobuhiro Tahara, Department of Medicine, Division of Cardio-Vascular Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume 830-0011, Japan. (Email: ntahara{at}med.kurume-u.ac.jp).

Objectives: We investigated factors for carotid artery inflammation by [¹⁸F]-fluorodeoxyglucose (FDG) positron emission tomography (PET).

Background: Inflammation is present in some atherosclerotic plaques. The FDG-PET is capable of identifying and quantifying vascular inflammation within atherosclerotic plaques.

Methods: The FDG-PET imaging was performed in 216 consecutive patients (63 ± 9 years, men:women 147:69) for cancer screening. Vascular inflammation in carotid atherosclerosis was quantified by measuring the standardized uptake value (SUV) of FDG into the artery.

Results: Multiple stepwise regression analysis revealed significant relationships between SUV and waist circumference (p < 0.001), hypertensive medication (p < 0.001), carotid intima-media thickness (p < 0.001), high-density lipoprotein cholesterol (p < 0.01, inversely), homeostasis model assessment of insulin resistance (p < 0.05), or high sensitivity C-reactive protein (p < 0.05). Age- and gender-adjusted SUV of FDG was significantly higher (p < 0.0001) in proportion to the accumulation of the number of the components of the metabolic syndrome. Thus, the metabolic syndrome was associated with increased FDG uptake in carotid atherosclerosis.

Conclusions: Our present study may suggest that the metabolic syndrome is associated with inflammation in carotid atherosclerosis. (Detection of Plaque Inflammation by Positron Emission Tomography (PET); http://www.clinicaltrials.gov/ct/show/NCT00114504; NCT00114504 [ClinicalTrials.gov] )

Abbreviations and Acronyms   BMI = body mass index   BP = blood pressure   CAD = coronary artery disease   CT = computed tomography   CVD = cerebrovascular disease   FDG = [18F]-fluorodeoxyglucose   FPG = fasting plasma glucose   HDL = high-density lipoprotein   HOMA-IR = homeostasis model assessment of insulin resistance   hsCRP = high sensitivity C-reactive protein   IMT = intima-media thickness   IRI = immunoreactive insulin   LDL = low-density lipoprotein   PET = positron emission tomography   SUV = standardized uptake value

This article has been cited by other articles:

				J. H.F. Rudd, F. Hyafil, and Z. A. Fayad Inflammation Imaging in Atherosclerosis Arterioscler. Thromb. Vasc. Biol., July 1, 2009; 29(7): 1009 - 1016. [Abstract] [Full Text] [PDF]

				L. J. Menezes, C. W. Kotze, B. F. Hutton, R. Endozo, J. C. Dickson, I. Cullum, S. W. Yusuf, P. J. Ell, and A. M. Groves Vascular Inflammation Imaging with 18F-FDG PET/CT: When to Image? J. Nucl. Med., June 1, 2009; 50(6): 854 - 857. [Abstract] [Full Text] [PDF]

				J. Wykrzykowska, S. Lehman, G. Williams, J. A. Parker, M. R. Palmer, S. Varkey, G. Kolodny, and R. Laham Imaging of Inflamed and Vulnerable Plaque in Coronary Arteries with 18F-FDG PET/CT in Patients with Suppression of Myocardial Uptake Using a Low-Carbohydrate, High-Fat Preparation J. Nucl. Med., April 1, 2009; 50(4): 563 - 568. [Abstract] [Full Text] [PDF]

				J. H.F. Rudd, K. S. Myers, S. Bansilal, J. Machac, M. Woodward, V. Fuster, M. E. Farkouh, and Z. A. Fayad Relationships Among Regional Arterial Inflammation, Calcification, Risk Factors, and Biomarkers: A Prospective Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography Imaging Study Circ Cardiovasc Imaging, March 1, 2009; 2(2): 107 - 115. [Abstract] [Full Text] [PDF]

				E. Falk, T. Thim, and I. B. Kristensen Atherosclerotic plaque, adventitia, perivascular fat, and carotid imaging. J. Am. Coll. Cardiol. Img., February 1, 2009; 2(2): 183 - 186. [Full Text] [PDF]

				S. J. Lee, Y. K. On, E. J. Lee, J. Y. Choi, B.-T. Kim, and K.-H. Lee Reversal of Vascular 18F-FDG Uptake with Plasma High-Density Lipoprotein Elevation by Atherogenic Risk Reduction J. Nucl. Med., August 1, 2008; 49(8): 1277 - 1282. [Abstract] [Full Text] [PDF]

				J. H.F. Rudd, K. S. Myers, S. Bansilal, J. Machac, C. A. Pinto, C. Tong, A. Rafique, R. Hargeaves, M. Farkouh, V. Fuster, et al. Atherosclerosis Inflammation Imaging with 18F-FDG PET: Carotid, Iliac, and Femoral Uptake Reproducibility, Quantification Methods, and Recommendations J. Nucl. Med., June 1, 2008; 49(6): 871 - 878. [Abstract] [Full Text] [PDF]

				J. Sanz, P. R. Moreno, and V. Fuster The year in atherothrombosis. J. Am. Coll. Cardiol., March 4, 2008; 51(9): 944 - 955. [Full Text] [PDF]

				N. J. Brown Aldosterone and Vascular Inflammation Hypertension, February 1, 2008; 51(2): 161 - 167. [Full Text] [PDF]

				A. N. DeMaria, J. J. Bax, O. Ben-Yehuda, P. Clopton, G. K. Feld, G. S. Ginsburg, B. H. Greenberg, J. D. Knoke, W. Y.W. Lew, J. A.C. Lima, et al. Highlights of the year in JACC 2007. J. Am. Coll. Cardiol., January 29, 2008; 51(4): 490 - 512. [Full Text] [PDF]

				M. Nahrendorf, H. Zhang, S. Hembrador, P. Panizzi, D. E. Sosnovik, E. Aikawa, P. Libby, F. K. Swirski, and R. Weissleder Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis Circulation, January 22, 2008; 117(3): 379 - 387. [Abstract] [Full Text] [PDF]

				M. P. S. Dunphy, H. Schoder, and H. W. Strauss Radionuclide Techniques for Identifying Vulnerable Plaque J. Nucl. Med., November 1, 2007; 48(11): 1753 - 1755. [Full Text] [PDF]

				D. Hartung, A. Petrov, N. Haider, S. Fujimoto, F. Blankenberg, A. Fujimoto, R. Virmani, F. D. Kolodgie, H. W. Strauss, and J. Narula Radiolabeled Monocyte Chemotactic Protein 1 for the Detection of Inflammation in Experimental Atherosclerosis J. Nucl. Med., November 1, 2007; 48(11): 1816 - 1821. [Abstract] [Full Text] [PDF]

				N. Tahara, H. Kai, H. Nakaura, M. Mizoguchi, M. Ishibashi, H. Kaida, K. Baba, N. Hayabuchi, and T. Imaizumi The prevalence of inflammation in carotid atherosclerosis: analysis with fluorodeoxyglucose positron emission tomography Eur. Heart J., September 2, 2007; 28(18): 2243 - 2248. [Abstract] [Full Text] [PDF]