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This Article Figures Only Full Text Full Text (PDF) View PC-Trial Information All Versions of this Article: j.jacc.2006.06.059v1 48/8/1652    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by van Dijk, N. Search for Related Content PubMed PubMed Citation Articles by van Dijk, N.

CLINICAL RESEARCH: SYNCOPE

Effectiveness of Physical Counterpressure Maneuvers in Preventing Vasovagal Syncope

The Physical Counterpressure Manoeuvres Trial (PC-Trial)

Nynke van Dijk, MD^_*,_*, Fabio Quartieri, MD, Jean-Jaques Blanc, MD, Roberto Garcia-Civera, MD, Michele Brignole, MD^||, Angel Moya, MD^¶, Wouter Wieling, MD, PhD^_* on behalf of the PC-Trial Investigators

^_* Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands
Department of Interventional Cardiology, Ospedale S. Maria Nuova, Reggio Emilia, Italy
Department of Cardiology, Hospital de la Cavale Blanche, Brest Cedex, France
Department of Cardiology, Hospital Clinico Universitario Valencia, Valencia, Spain
^|| Department of Cardiology, Ospedali del Tigullio, Lavanga, Italy
^¶ Department of Cardiology, Hospital General Vall d’Hebron, Barcelona, Spain.

Manuscript received April 20, 2006; revised manuscript received June 6, 2006, accepted June 19, 2006.

^_* Reprint requests and correspondence: Dr. Nynke van Dijk, Department of Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. (Email: n.vandijk{at}amc.uva.nl).

OBJECTIVES: In this study, we assessed the effectiveness of physical counterpressure maneuvers (PCM) in daily life.

BACKGROUND: There is presently no evidence-based therapy for vasovagal syncope. Current treatment consists of explanation and life-style advice. Physical counterpressure maneuvers have been shown to raise blood pressure and to control or abort vasovagal episodes in laboratory conditions.

METHODS: We performed a multicenter, prospective, randomized clinical trial, which included 223 patients age 38.6 (±15.4) years with recurrent vasovagal syncope and recognizable prodromal symptoms. One hundred and seventeen patients were randomized to standardized conventional therapy alone, and 106 patients received conventional therapy plus training in PCM.

RESULTS: The median yearly syncope burden during follow-up was significantly lower in the group trained in PCM than in the control group (p = 0.004). During a mean follow-up period of 14 months, overall 50.9% of the patients with conventional treatment and 31.6% of the patients trained in PCM experienced a syncopal recurrence (p = 0.005). Actuarial recurrence-free survival was better in the treatment group (log-rank p = 0.018), resulting in a relative risk reduction of 39% (95% confidence interval, 11% to 53%). No adverse events were reported.

CONCLUSIONS: Physical counterpressure maneuvers are a risk-free, effective, and low-cost treatment method in patients with vasovagal syncope and recognizable prodromal symptoms, and should be advised as first-line treatment in patients presenting with vasovagal syncope with prodromal symptoms. (The PC-Trial; http://www.controlled-trials.com/isrctn/trial/45146526/0/45146526.html; ISRCTN45146526 [controlled-trials.com] )

Abbreviations and Acronyms   ESC = European Society of Cardiology   PCM = physical counterpressure maneuvers   PC-Trial = Physical Counterpressure Manoeuvres Trial

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