This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: j.jacc.2006.06.048v1 48/7/1387    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Abe, N. Articles by Okumura, K. Search for Related Content PubMed PubMed Citation Articles by Abe, N. Articles by Okumura, K.

CLINICAL RESEARCH: HEART FAILURE

Increased Level of Pericardial Insulin-Like Growth Factor-1 in Patients With Left Ventricular Dysfunction and Advanced Heart Failure

Naoki Abe, MD^_*, Toshiro Matsunaga, MD^_*, Kunihiko Kameda, MD^_*, Hirofumi Tomita, MD^_*, Takayuki Fujiwara, MD^_*, Hiroshi Ishizaka, MD^_*, Hiroyuki Hanada, MD^_*, Kozo Fukui, MD, Ikuo Fukuda, MD, Tomohiro Osanai, MD^_* and Ken Okumura, MD^_*,_*

^_* Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
First Department of Surgery, Hirosaki University School of Medicine, Hirosaki, Japan.

Manuscript received February 6, 2006; revised manuscript received June 6, 2006, accepted June 12, 2006.

^_* Reprint requests and correspondence: Dr. Ken Okumura, Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 0368562, Japan. (Email: okumura{at}cc.hirosaki-u.ac.jp).

OBJECTIVES: To test the hypothesis that the cardiac insulin-like growth factor-1 (IGF-1) system is up-regulated in the failing heart, we measured the pericardial (cardiac) and plasma (circulating) IGF-1 levels in coronary artery disease patients.

BACKGROUND: Local IGF-1 systems are regulated differently from the systemic IGF-1 system. The cardiac IGF-1 system is up-regulated by the increased left ventricular (LV) wall stress. However, it remains unknown how this system is affected in LV dysfunction and heart failure.

METHODS: We measured the plasma and pericardial fluid levels of IGF-1 and brain natriuretic peptide (BNP) in 87 coronary artery disease patients undergoing cardiac surgery, and examined their relationships with LV function and heart failure severity. The expressions of IGF-1 and IGF-1 receptor proteins were examined in endomyocardial biopsies obtained from other patients with normal or impaired LV function.

RESULTS: The pericardial IGF-1 and BNP levels were positively correlated with the plasma BNP level (both p < 0.001). The pericardial IGF-1 level was increased in heart failure patients, whereas the plasma IGF-1 level was rather decreased. The pericardial IGF-1 level was inversely correlated with the LV ejection fraction (p < 0.001), whereas the plasma IGF-1 level was not. Positive immunostaining for IGF-1 and IGF-1 receptor proteins was enhanced in myocardial biopsies from failing hearts compared with those from nonfailing hearts.

CONCLUSIONS: The pericardial IGF-1 level was increased in patients with LV dysfunction and heart failure, whereas the plasma IGF-1 level was decreased. These results may indicate that up-regulation of the cardiac IGF-1 system serves as a compensatory mechanism for LV dysfunction.

Abbreviations and Acronyms   ANOVA = analysis of variance   BNP = brain natriuretic peptide   CABG = coronary artery bypass graft surgery   CAD = coronary artery disease   IGF-1 = insulin-like growth factor-1   IGFBP = insulin-like growth factor binding protein   LVEF = left ventricular ejection fraction   LVG = left ventriculography   NYHA = New York Heart Association

This article has been cited by other articles:

				H. K. Haider, S. Jiang, N. M. Idris, and M. Ashraf IGF-1-Overexpressing Mesenchymal Stem Cells Accelerate Bone Marrow Stem Cell Mobilization via Paracrine Activation of SDF-1{alpha}/CXCR4 Signaling to Promote Myocardial Repair Circ. Res., November 21, 2008; 103(11): 1300 - 1308. [Abstract] [Full Text] [PDF]

				F. Limana, A. Zacheo, D. Mocini, A. Mangoni, G. Borsellino, A. Diamantini, R. De Mori, L. Battistini, E. Vigna, M. Santini, et al. Identification of Myocardial and Vascular Precursor Cells in Human and Mouse Epicardium Circ. Res., December 7, 2007; 101(12): 1255 - 1265. [Abstract] [Full Text] [PDF]