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J Am Coll Cardiol, 2006; 48:464-470, doi:10.1016/j.jacc.2006.04.072 (Published online 11 July 2006).
© 2006 by the American College of Cardiology Foundation
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CLINICAL RESEARCH: CARDIAC RESYNCHRONIZATION THERAPY

Benefit of Combined Resynchronization and Defibrillator Therapy in Heart Failure Patients With and Without Ventricular Arrhythmias

Claudia Ypenburg, MD, Lieselot van Erven, MD, PhD, Gabe B. Bleeker, MD, Jeroen J. Bax, MD, PhD, Marianne Bootsma, MD, PhD, Maurits C. Wijffels, MD, PhD, Ernst E. van der Wall, MD, PhD and Martin J. Schalij, MD, PhD*

Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands

Manuscript received December 22, 2005; revised manuscript received April 7, 2006, accepted April 11, 2006.

* Reprint requests and correspondence: Dr. Martin J. Schalij, Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands. (Email: M.J.Schalij{at}LUMC.nl).

OBJECTIVES: We attempted to assess the efficacy of combined cardiac resynchronization therapy-implantable cardioverter-defibrillator (CRT-ICD) in heart failure patients with and without ventricular arrhythmias.

BACKGROUND: Because CRT and ICDs both lower all-cause mortality in patients with advanced heart failure, combination of both therapies in a single device is challenging.

METHODS: A total of 191 consecutive patients with advanced heart failure, left ventricular ejection fraction <35%, and a QRS duration >120 ms received CRT-ICD. Seventy-one patients had a history of ventricular arrhythmias (secondary prevention); 120 patients did not have prior ventricular arrhythmias (primary prevention). During follow-up, ICD therapy rate, clinical improvement after 6 months, and mortality rate were evaluated.

RESULTS: During follow-up (18 ± 4 months), primary prevention patients experienced less appropriate ICD therapies than secondary prevention patients (21% vs. 35%, p < 0.05). Multivariate analysis revealed, however, no predictors of ICD therapy. Furthermore, a similar, significant, improvement in clinical parameters was observed at 6 months in both groups. Also, the mortality rate in the primary prevention group was lower than in the secondary prevention group (3% vs. 18%, p < 0.05).

CONCLUSIONS: As 21% of the primary prevention patients and 35% of the secondary prevention patients experienced appropriate ICD therapy within 2 years after implant, and no predictors of ICD therapy could be identified, implantation of a CRT-ICD device should be considered in all patients eligible for CRT.

Abbreviations and Acronyms
  ATP = antitachycardia pacing
  CI = confidence interval
  CRT = cardiac resynchronization therapy
  HF = heart failure
  HR = hazard ratio
  ICD = implantable cardioverter-defibrillator
  LV = left ventricle/ventricular
  LVEF = left ventricular ejection fraction
  NYHA = New York Heart Association
  VF = ventricular fibrillation
  VT = ventricular tachycardia




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