HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: j.jacc.2006.02.059v1 48/1/144    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baks, T. Articles by de Feyter, P. J. Search for Related Content PubMed PubMed Citation Articles by Baks, T. Articles by de Feyter, P. J.

CLINICAL RESEARCH: CARDIAC IMAGING

Multislice Computed Tomography and Magnetic Resonance Imaging for the Assessment of Reperfused Acute Myocardial Infarction

Timo Baks, MD^_*,, Filippo Cademartiri, MD, PhD^_*,, Amber D. Moelker, MSc^_*, Annick C. Weustink, MD, Robert-Jan van Geuns, MD, PhD^_*,, Nico R. Mollet, MD, PhD^_*,, Gabriel P. Krestin, MD, PhD, Dirk J. Duncker, MD, PhD^_* and Pim J. de Feyter, MD, PhD, FACC^_*,,_*

^_* Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands
Department of Radiology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Manuscript received November 2, 2005; revised manuscript received February 10, 2006, accepted February 21, 2006.

^_* Reprint requests and correspondence: Dr. Pim J. de Feyter, Department of Cardiology and Radiology, Thorax Center–Room Ba 591, Erasmus Medical Center, Dr. Molewaterplein 40, 3000 GD Rotterdam, the Netherlands. (Email: p.j.defeyter{at}erasmusmc.nl).

OBJECTIVES: We evaluated the accuracy of in vivo delayed-enhancement multislice computed tomography (DE-MSCT) and delayed-enhancement magnetic resonance imaging (DE-MRI) for the assessment of myocardial infarct size using postmortem triphenyltetrazolium chloride (TTC) pathology as standard of reference.

BACKGROUND: The diagnostic value of DE-MSCT for the assessment of acute reperfused myocardial infarction is currently unclear.

METHODS: In 10 domestic pigs (25 to 30 kg), the circumflex coronary artery was balloon-occluded for 2 h followed by reperfusion. After 5 days (3 to 7 days), DE-MRI (1.5-T) was performed 15 min after administration of 0.2 mmol/kg gadolinium-DTPA using an inversion recovery gradient echo technique. On the same day, DE-MSCT (64-slice) was performed 15 min after administration of 1 gI/kg of iodinated contrast material. One day after imaging, hearts were excised, sectioned in 8 mm short-axis slices, and stained with TTC. Infarct size was defined as the hyperenhanced area on DE-MSCT and DE-MRI images and the TTC-negative area on TTC pathology slices. Infarct size was expressed as percentage of total slice area.

RESULTS: Infarct size determined by DE-MSCT and DE-MRI showed a good correlation with infarct size assessed with TTC pathology (R² = 0.96 [p < 0.001] and R² = 0.93 [p < 0.001], respectively). The correlation between DE-MSCT and DE-MRI was also good (R² = 0.96; p < 0.001). The relative difference in CT attenuation value of infarcted myocardium compared to remote myocardium was 191 ± 18%. The relative MR signal intensity between infarcted myocardium and remote myocardium was 554 ± 156%.

CONCLUSIONS: We demonstrated that DE-MSCT can assess acute reperfused myocardial infarction in good agreement with in vivo DE-MRI and TTC pathology.

Abbreviations and Acronyms   CT = computerized tomography   DE-MRI = delayed-enhancement magnetic resonance imaging   DE-MSCT = delayed-enhancement multislice computed tomography   HU = Hounsfield units   TTC = triphenyltetrazolium chloride

This article has been cited by other articles:

				J.-B. le Polain de Waroux, A.-C. Pouleur, C. Goffinet, A. Pasquet, J.-L. Vanoverschelde, and B. L. Gerber Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging Eur. Heart J., September 1, 2008; (2008) ehn381v1. [Abstract] [Full Text] [PDF]

				A. S. Jaffe Key Issues in the Developing Synergism between Cardiovascular Imaging and Biomarkers Clin. Chem., September 1, 2008; 54(9): 1432 - 1442. [Abstract] [Full Text] [PDF]

				L. Boussel, M. Ribagnac, E. Bonnefoy, P. Staat, B. M. Elicker, D. Revel, and P. Douek Assessment of Acute Myocardial Infarction Using MDCT After Percutaneous Coronary Intervention: Comparison with MRI Am. J. Roentgenol., August 1, 2008; 191(2): 441 - 447. [Abstract] [Full Text] [PDF]

				R. J. Gibbons, P. A. Araoz, and E. E. Williamson The Year in Cardiac Imaging J. Am. Coll. Cardiol., September 4, 2007; 50(10): 988 - 1003. [Full Text] [PDF]

				A. N. DeMaria, O. Ben-Yehuda, G. K. Feld, G. S. Ginsburg, B. H. Greenberg, W. Y.W. Lew, J. A.C. Lima, A. S. Maisel, J. Narula, D. J. Sahn, et al. Highlights of the Year in JACC 2006 J. Am. Coll. Cardiol., January 30, 2007; 49(4): 509 - 527. [Full Text] [PDF]

				A. D. Moelker, T. Baks, E.J. van den Bos, R.J. van Geuns, P.J. de Feyter, D. J. Duncker, and W.J. van der Giessen Reduction in infarct size, but no functional improvement after bone marrow cell administration in a porcine model of reperfused myocardial infarction Eur. Heart J., December 2, 2006; 27(24): 3057 - 3064. [Abstract] [Full Text] [PDF]