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J Am Coll Cardiol, 2006; 47:1777-1785, doi:10.1016/j.jacc.2006.02.002 (Published online 11 April 2006).
© 2006 by the American College of Cardiology Foundation
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CARDIOVASCULAR GENOMIC MEDICINE: VIEWPOINT AND COMMENTARY

Regeneration Gaps

Observations on Stem Cells and Cardiac Repair

Charles E. Murry, MD, PhDa,*, Hans Reinecke, PhD and Lil M. Pabon, PhD

Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, Seattle, Washington

Manuscript received November 4, 2005; revised manuscript received November 22, 2005, accepted December 19, 2005.

* Reprint requests and correspondence: Dr. Charles E. Murry, Director, Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, 815 Mercer Street, Seattle, Washington 98109. (Email: murry{at}u.washington.edu).

Substantial evidence indicates that cell transplantation can improve function of the infarcted heart. A surprisingly wide range of non-myogenic cell types improves ventricular function, suggesting that benefit may result in part from mechanisms that are distinct from true myocardial regeneration. While clinical trials explore cells derived from skeletal muscle and bone marrow, basic researchers are investigating sources of new cardiomyocytes, such as resident myocardial progenitors and embryonic stem cells. In this commentary, we briefly review the evolution of cell-based cardiac repair, discuss the current state of clinical research, and offer some thoughts on how newcomers can critically evaluate this emerging field.

Abbreviations and Acronyms
  EGFP = enhanced green fluorescent protein
  ESC = embryonic stem cell
  LacZ = beta-galactosidase
  Sca = stem cell antigen
  SDF = stromal-derived factor




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 J. Thorac. Cardiovasc. Surg.Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
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Home page
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Home page
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Home page
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Circ. Res., August 17, 2007; 101(4): 323 - 325.
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Home page
 J. Physiol.Home page
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J. Physiol., April 15, 2007; 580(2): 639 - 648.
[Abstract] [Full Text] [PDF]

Home page
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Physiol Rev, April 1, 2007; 87(2): 521 - 544.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. S. Jonker, L. Zhang, S. Louey, G. D. Giraud, K. L. Thornburg, and J. J. Faber
Myocyte enlargement, differentiation, and proliferation kinetics in the fetal sheep heart
J Appl Physiol, March 1, 2007; 102(3): 1130 - 1142.
[Abstract] [Full Text] [PDF]

Home page
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S. S. Jonker, J. J. Faber, D. F. Anderson, K. L. Thornburg, S. Louey, and G. D. Giraud
Sequential growth of fetal sheep cardiac myocytes in response to simultaneous arterial and venous hypertension
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R913 - R919.
[Abstract] [Full Text] [PDF]

Home page
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[Full Text] [PDF]

Home page
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Reduction in infarct size, but no functional improvement after bone marrow cell administration in a porcine model of reperfused myocardial infarction
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