Plaque Characterization With Optical Coherence Tomography
Debra Stamper, PhD*, ,
Neil J. Weissman, MD, FACC and
Mark Brezinski, MD, PhD*, ,a,*
* Department of Orthopedic Surgery, Brigham & Womens Hospital, Boston, Massachusetts
Harvard Medical School, Boston, Massachusetts
Cardiovascular Research Institute, Washington Hospital Center, Washington, DC
Manuscript received August 18, 2005;
revised manuscript received September 12, 2005,
accepted October 17, 2005.
* Reprint requests and correspondence: Dr. Mark Brezinski, Orthopedics Research, MRB105, Brigham & Womens Hospital. 75 Francis Street, Boston, Massachusetts 02115 (Email: mebrezin{at}mit.edu).
The identification of unstable plaque is central in risk-stratifying patients for acute coronary events. Optical coherence tomography (OCT) is a recently introduced imaging modality that has shown considerable promise for the identification of high-risk plaques. Advantages of OCT include its high resolution (4 to 20 µm), high data acquisition rate, small and inexpensive guidewires/catheters, and ability to be combined with adjuvant optical techniques. This article summarizes the current state of intravascular OCT imaging, focusing on potential markers of instability and current limitations.
|
Abbreviations and Acronyms
| | ACS = acute coronary syndrome | | AMI = acute myocardial infarction | | IV = intravenous | | IVUS = intravascular ultrasound | | OCT = ocular coherence tomography | | PS-OCT = polarization-sensitive OCT | | TCFA = thin-capped fibroatheromas |
|
This article has been cited by other articles:

|
 |

|
 |
 
S. S. Kim, Z. M. Hijazi, R. M. Lang, and B. P. Knight
The use of intracardiac echocardiography and other intracardiac imaging tools to guide noncoronary cardiac interventions.
J. Am. Coll. Cardiol.,
June 9, 2009;
53(23):
2117 - 2128.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. Wykrzykowska, S. Lehman, G. Williams, J. A. Parker, M. R. Palmer, S. Varkey, G. Kolodny, and R. Laham
Imaging of Inflamed and Vulnerable Plaque in Coronary Arteries with 18F-FDG PET/CT in Patients with Suppression of Myocardial Uptake Using a Low-Carbohydrate, High-Fat Preparation
J. Nucl. Med.,
April 1, 2009;
50(4):
563 - 568.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. U Farooq, A. Khasnis, A. Majid, and M. Y Kassab
The role of optical coherence tomography in vascular medicine
Vascular Medicine,
February 1, 2009;
14(1):
63 - 71.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Motoyama, T. Kondo, M. Sarai, A. Sugiura, H. Harigaya, T. Sato, K. Inoue, M. Okumura, J. Ishii, H. Anno, et al.
Multislice Computed Tomographic Characteristics of Coronary Lesions in Acute Coronary Syndromes
J. Am. Coll. Cardiol.,
July 24, 2007;
50(4):
319 - 326.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. J.G.L. de Smet and F. Zijlstra
A look at drug eluting stents with optical coherence tomography
Eur. Heart J.,
April 2, 2007;
28(8):
918 - 919.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Burris, K. Schwartz, C.-M. Tang, M. S. Jafri, J. Schmitt, M. H. Kwon, O. Toshinaga, J. Gu, J. Brown, E. Brown, et al.
Catheter-based infrared light scanner as a tool to assess conduit quality in coronary artery bypass surgery
J. Thorac. Cardiovasc. Surg.,
February 1, 2007;
133(2):
419 - 427.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Waxman, F. Ishibashi, and J. E. Muller
Detection and Treatment of Vulnerable Plaques and Vulnerable Patients: Novel Approaches to Prevention of Coronary Events
Circulation,
November 28, 2006;
114(22):
2390 - 2411.
[Full Text]
[PDF]
|
 |
|
|