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J Am Coll Cardiol, 2006; 47:69-79, doi:10.1016/j.jacc.2005.10.067
© 2006 by the American College of Cardiology Foundation
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Plaque Characterization With Optical Coherence Tomography

Debra Stamper, PhD*,{dagger}, Neil J. Weissman, MD, FACC{ddagger} and Mark Brezinski, MD, PhD*,{dagger},a,*

* Department of Orthopedic Surgery, Brigham & Women’s Hospital, Boston, Massachusetts
{dagger} Harvard Medical School, Boston, Massachusetts
{ddagger} Cardiovascular Research Institute, Washington Hospital Center, Washington, DC

Manuscript received August 18, 2005; revised manuscript received September 12, 2005, accepted October 17, 2005.

* Reprint requests and correspondence: Dr. Mark Brezinski, Orthopedics Research, MRB105, Brigham & Women’s Hospital. 75 Francis Street, Boston, Massachusetts 02115 (Email: mebrezin{at}mit.edu).

The identification of unstable plaque is central in risk-stratifying patients for acute coronary events. Optical coherence tomography (OCT) is a recently introduced imaging modality that has shown considerable promise for the identification of high-risk plaques. Advantages of OCT include its high resolution (4 to 20 µm), high data acquisition rate, small and inexpensive guidewires/catheters, and ability to be combined with adjuvant optical techniques. This article summarizes the current state of intravascular OCT imaging, focusing on potential markers of instability and current limitations.

Abbreviations and Acronyms
  ACS = acute coronary syndrome
  AMI = acute myocardial infarction
  IV = intravenous
  IVUS = intravascular ultrasound
  OCT = ocular coherence tomography
  PS-OCT = polarization-sensitive OCT
  TCFA = thin-capped fibroatheromas




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