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Plaque Characterization With Optical Coherence Tomography

Debra Stamper, PhD^_*,, Neil J. Weissman, MD, FACC and Mark Brezinski, MD, PhD^_*,,a,_*

^_* Department of Orthopedic Surgery, Brigham & Women’s Hospital, Boston, Massachusetts
Harvard Medical School, Boston, Massachusetts
Cardiovascular Research Institute, Washington Hospital Center, Washington, DC

Manuscript received August 18, 2005; revised manuscript received September 12, 2005, accepted October 17, 2005.

^_* Reprint requests and correspondence: Dr. Mark Brezinski, Orthopedics Research, MRB105, Brigham & Women’s Hospital. 75 Francis Street, Boston, Massachusetts 02115 (Email: mebrezin{at}mit.edu).

The identification of unstable plaque is central in risk-stratifying patients for acute coronary events. Optical coherence tomography (OCT) is a recently introduced imaging modality that has shown considerable promise for the identification of high-risk plaques. Advantages of OCT include its high resolution (4 to 20 µm), high data acquisition rate, small and inexpensive guidewires/catheters, and ability to be combined with adjuvant optical techniques. This article summarizes the current state of intravascular OCT imaging, focusing on potential markers of instability and current limitations.

Abbreviations and Acronyms   ACS = acute coronary syndrome   AMI = acute myocardial infarction   IV = intravenous   IVUS = intravascular ultrasound   OCT = ocular coherence tomography   PS-OCT = polarization-sensitive OCT   TCFA = thin-capped fibroatheromas

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