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J Am Coll Cardiol, 2006; 47:1655-1662, doi:10.1016/j.jacc.2006.01.041 (Published online 23 March 2006).
© 2006 by the American College of Cardiology Foundation
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CLINICAL RESEARCH: CARDIAC IMAGING

Noninvasive Assessment of Plaque Morphology and Composition in Culprit and Stable Lesions in Acute Coronary Syndrome and Stable Lesions in Stable Angina by Multidetector Computed Tomography

Udo Hoffmann, MD*,*, Fabian Moselewski, BS*,{dagger}, Koen Nieman, MD*,{dagger}, Ik-Kyung Jang, MD, PhD{dagger}, Maros Ferencik, MD, PhD*, Ayaz M. Rahman, MD*, Ricardo C. Cury, MD*, Suhny Abbara, MD*, Hamid Joneidi-Jafari, BS*, Stephan Achenbach, MD*,{dagger},{ddagger} and Thomas J. Brady, MD*

* Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
{dagger} Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
{ddagger} Department of Internal Medicine II, University of Erlangen, Erlangen, Germany

Manuscript received June 13, 2005; revised manuscript received September 25, 2005, accepted November 9, 2005.

* Reprint requests and correspondence: Dr. Udo Hoffmann, Department of Radiology, Massachusetts General Hospital, 165 Charles River Plaza, Suite 400, Boston, Massachusetts 02114. (Email: uhoffmann{at}partners.org).

OBJECTIVES: The purpose of this study was to assess morphology and composition of culprit and stable coronary lesions by multidetector computed tomography (MDCT).

BACKGROUND: Noninvasive identification of culprit lesions has the potential to improve noninvasive risk stratification in patients with acute chest pain.

METHODS: Thirty-seven patients with acute coronary syndrome (ACS) or stable angina underwent coronary 16-slice MDCT and invasive selective angiography. In all significant coronary lesions two observers measured the degree of stenosis, plaque area at stenosis, and remodeling index and assessed plaque composition. Differences between culprit lesions in patients with ACS and stable lesions in patients with ACS or stable angina were determined.

RESULTS: We analyzed 40 lesions with excellent image quality in 14 patients with ACS and 9 patients with stable angina. Culprit lesions in patients with ACS (n = 14) had significantly greater plaque area and a higher remodeling index than both stable lesions in patients with ACS (n = 13) and in patients with stable angina (n = 13) (17.5 ± 5.9 mm2 vs. 9.1 ± 4.8 mm2 vs. 13.5 ± 10.7 mm2, p = 0.02; and 1.4 ± 0.3 vs. 1.0 ± 0.4 vs. 1.2 ± 0.3, p = 0.04, respectively). The prevalence of non-calcified plaque was 100%, 62%, and 77%, respectively, and the prevalence of calcified plaque was 71%, 92%, and 85%, respectively, in culprit lesions in patients with ACS and in stable lesions in patients with ACS or stable angina.

CONCLUSIONS: We introduce the concept of noninvasive detection and characterization of coronary atherosclerotic lesions in patients with ACS by MDCT. We identified differences in lesion morphology and plaque composition between culprit lesions in ACS and stable lesions in ACS or stable angina, consistent with previous intravascular ultrasound studies.

Abbreviations and Acronyms
  ACS = acute coronary syndrome
  CT = computed tomography
  ECG = electrocardiogram
  HU = Hounsfield units
  IVUS = intravascular ultrasound
  LAD = left anterior descending (coronary artery)
  LCX = left circumflex
  LM = left main (coronary artery)
  MDCT = multidetector computed tomography
  NSTEMI = non–ST-segment elevation myocardial infarction
  RCA = right coronary artery
  RI = remodeling index




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