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This Article Figures Only Full Text Full Text (PDF) View Online Appendix All Versions of this Article: j.jacc.2005.10.048v1 47/5/1029    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (14) Citing Articles via Google Scholar Google Scholar Articles by Chaowalit, N. Articles by Pellikka, P. A. Search for Related Content PubMed PubMed Citation Articles by Chaowalit, N. Articles by Pellikka, P. A.

CLINICAL RESEARCH: ECHOCARDIOGRAPHY

Dobutamine Stress Echocardiography in Patients With Diabetes Mellitus

Enhanced Prognostic Prediction Using a Simple Risk Score

Mayo Clinic, Rochester, Minnesota

Manuscript received October 14, 2004; revised manuscript received October 12, 2005, accepted October 18, 2005.

^_* Reprint requests and correspondence: Dr. Patricia A. Pellikka, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905 (Email: pellikka.patricia{at}mayo.edu).

OBJECTIVES: We sought to determine the prognostic value of dobutamine stress echocardiography (DSE) for predicting long-term outcomes in a large cohort with diabetes mellitus and to develop a simple risk score using clinical and echocardiographic data.

BACKGROUND: Neither risk scores nor long-term prognostic value of DSE has been described in a large diabetic population.

METHODS: We studied 2,349 patients with diabetes mellitus (1,338 men, 67 ± 11 years of age) during a follow-up of 5.4 ± 2.2 years.

RESULTS: Mortality and morbidity (myocardial infarction and late coronary revascularization) occurred in 1,044 (44%) and 309 (13%) patients, respectively. Addition of stress echocardiographic variables to the clinical and rest echocardiographic model provided incremental prognostic information for predicting mortality (chi-square = 243 to 270, p < 0.0001) and morbidity (chi-square = 38 to 78, p < 0.0001). For each end point, a simple risk score was derived according to the estimated values of beta coefficients of multivariate predictors (insulin therapy, smoking, failure to achieve target heart rate, percentage of ischemic segments, and impaired left ventricular systolic function) and resulted in an assessment of risk among all age groups. The C-statistic values were 0.60 to 0.64, indicating modest discrimination. The estimated five-year event-free survivals of patients in three risk categories were 94%, 86%, and 80% for morbidity (p < 0.00001) and 69%, 60%, and 47% for mortality (p < 0.0001).

CONCLUSIONS: In patients with diabetes mellitus, a simple and practical risk score using clinical variables and results of DSE stratified patients into three risk groups for mortality and cardiovascular morbidity.

Abbreviations and Acronyms   CAD = coronary artery disease   DSE = dobutamine stress echocardiography   LVESV = left ventricular end-systolic volume   MI = myocardial infarction   WMA = wall motion abnormality

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