|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 2006; 47:332-337, doi:10.1016/j.jacc.2005.06.088
(Published online 20 December 2005). © 2006 by the American College of Cardiology Foundation |
* Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia
Division of Cardiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Manuscript received March 24, 2005; revised manuscript received June 6, 2005, accepted June 14, 2005.
* Reprint requests and correspondence to: Dr. Bobby V. Khan, Division of Cardiology, Department of Medicine, Emory University School of Medicine, 69 Jesse Hill Drive SE, C233, Atlanta, Georgia 30303. (Email: bkhan{at}emory.edu).
OBJECTIVES: This study examined the effect of statin therapy on vascular markers of inflammation and echocardiographic findings in patients with nonischemic forms of cardiomyopathy.
BACKGROUND: Despite advances in therapy, morbidity and mortality from heart failure (HF) remain high. We wished to determine whether treatment with atorvastatin affects left ventricular (LV) systolic function and markers of inflammation in patients with nonischemic HF.
METHODS: A total of 108 patients with nonischemic HF and a left ventricular ejection fraction (LVEF) 
35% were randomized to either atorvastatin 20 mg/day or placebo in a double-blinded fashion for a 12-month period. The LVEF and LV end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) were determined by echocardiography. Serum markers of inflammation and oxidation were also measured.
RESULTS: The LVEF increased from 0.33 ± 0.05 to 0.37 ± 0.04 (p = 0.01) in the atorvastatin group over the 12-month follow-up period, whereas those patients in the placebo group experienced a decline in ejection fraction during the same time period. In addition, LVEDD was reduced from 57.1 ± 5.9 mm to 53.4 ± 5.1 mm (p = 0.007) and LVESD was reduced from 42.4 ± 3.8 mm to 39.1 ± 3.8 mm (p = 0.02) in the cohort of patients treated with atorvastatin; these dimensions increased in the placebo group. There was an increase in erythrocyte superoxide dismutase (E-SOD) activity, and there were significant reductions in serum levels of high sensitivity C-reactive protein, interleukin-6 (IL-6), and tumor necrosis factor-alpha receptor II (TNF-
RII) in the atorvastatin group.
CONCLUSIONS: The use of atorvastatin in patients with nonischemic HF improves LVEF and attenuates adverse LV remodeling. The effects on soluble levels of several inflammatory markers with atorvastatin suggest, in part, mechanisms by which statins might exert their beneficial effects in nonischemic HF.
| ||||||||||||||
This article has been cited by other articles:
|
|
 |
|
  Y. Ye, Y. Lin, J. R. Perez-Polo, B. F. Uretsky, Z. Ye, B. C. Tieu, and Y. Birnbaum Phosphorylation of 5-Lipoxygenase at Ser523 by Protein Kinase A Determines Whether Pioglitazone and Atorvastatin Induce Proinflammatory Leukotriene B4 or Anti-Inflammatory 15-Epi-Lipoxin A4 Production J. Immunol., September 1, 2008; 181(5): 3515 - 3523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Samson The Role of Statin Drugs in the Management of the Peripheral Vascular Patient Vascular and Endovascular Surgery, August 1, 2008; 42(4): 352 - 366. [Abstract] [PDF]
|
|
|
|
 |
|
 R. C Parish and J. D Evans Inflammation in Chronic Heart Failure Ann. Pharmacother., July 1, 2008; 42(7): 1002 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. G. Athyros, A. I. Kakafika, K. Tziomalos, A. Karagiannis, and D. P. Mikhailidis CORONA, Statins, and Heart Failure: Who Lost the Crown? Angiology, March 1, 2008; 59(1): 5 - 8. [PDF]
|
|
|
|
 |
|
 K. Ramasubbu, J. Estep, D. L. White, A. Deswal, and D. L. Mann Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy. J. Am. Coll. Cardiol., January 29, 2008; 51(4): 415 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Turner, R. S. Mughal, P. Warburton, D. J. O'Regan, S. G. Ball, and K. E. Porter Mechanism of TNF{alpha}-induced IL-1{alpha}, IL-1{beta} and IL-6 expression in human cardiac fibroblasts: Effects of statins and thiazolidinediones Cardiovasc Res, October 1, 2007; 76(1): 81 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Zaca, S. Rastogi, M. Imai, M. Wang, V. G. Sharov, A. Jiang, S. Goldstein, and H. N. Sabbah Chronic Monotherapy With Rosuvastatin Prevents Progressive Left Ventricular Dysfunction and Remodeling in Dogs With Heart Failure J. Am. Coll. Cardiol., August 7, 2007; 50(6): 551 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Del Porto, B. Lagana, S. Lai, I. Nofroni, F. Tinti, M. Vitale, E. Podesta, A. P. Mitterhofer, and R. D'Amelio Response to anti-tumour necrosis factor alpha blockade is associated with reduction of carotid intima-media thickness in patients with active rheumatoid arthritis Rheumatology, July 1, 2007; 46(7): 1111 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Gupta, L. C. Plantinga, N. E. Fink, M. L. Melamed, J. Coresh, C. S. Fox, N. W. Levin, and N. R. Powe Statin Use and Hospitalization for Sepsis in Patients With Chronic Kidney Disease JAMA, April 4, 2007; 297(13): 1455 - 1464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Khush, D. D. Waters, V. Bittner, P. C. Deedwania, J. J.P. Kastelein, S. J. Lewis, and N. K. Wenger Effect of High-Dose Atorvastatin on Hospitalizations for Heart Failure: Subgroup Analysis of the Treating to New Targets (TNT) Study Circulation, February 6, 2007; 115(5): 576 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.H. W. Tang and G. S. Francis The Year in Heart Failure J. Am. Coll. Cardiol., December 19, 2006; 48(12): 2575 - 2583. [Full Text] [PDF]
|
|
|
|
|
|
A. S. Go, W. Y. Lee, J. Yang, J. C. Lo, and J. H. Gurwitz Statin therapy and risks for death and hospitalization in chronic heart failure. JAMA, November 1, 2006; 296(17): 2105 - 2111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A F Leite-Moreira and P Castro-Chaves Heart failure: statins for all? Heart, November 1, 2006; 92(11): 1537 - 1538. [Full Text] [PDF]
|
|
|
|
|
|
A. Radaelli, M. Cazzaniga, A. Viola, G. Balestri, M. B. Janetti, M. G. Signorini, P. Castiglioni, A. Azzellino, G. Mancia, and A. U. Ferrari Enhanced Baroreceptor Control of the Cardiovascular System by Polyunsaturated Fatty Acids in Heart Failure Patients J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1600 - 1606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sola and B. V. Khan Reply J. Am. Coll. Cardiol., September 19, 2006; 48(6): 1284 - 1284. [Full Text] [PDF]
|
|
|
|
|
|
J. J. Goldberger, H. Subacius, A. Schaechter, A. Howard, R. Berger, A. Shalaby, J. Levine, A. H. Kadish, and for the DEFINITE Investigators Effects of Statin Therapy on Arrhythmic Events and Survival in Patients With Nonischemic Dilated Cardiomyopathy J. Am. Coll. Cardiol., September 19, 2006; 48(6): 1228 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bahl and D. S. Chongtham Atorvastatin in Nonischemic Left Ventricular Systolic Dysfunction J. Am. Coll. Cardiol., September 19, 2006; 48(6): 1283 - 1283. [Full Text] [PDF]
|
|
|
|
|
|
B. M. Scirica, D. A. Morrow, C. P. Cannon, K. K. Ray, M. S. Sabatine, P. Jarolim, A. Shui, C. H. McCabe, E. Braunwald, and for the PROVE IT-TIMI 22 Investigators Intensive Statin Therapy and the Risk of Hospitalization for Heart Failure After an Acute Coronary Syndrome in the PROVE IT-TIMI 22 Study J. Am. Coll. Cardiol., June 6, 2006; 47(11): 2326 - 2331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Statins for Nonischemic HF? Journal Watch Cardiology, February 23, 2006; 2006(223): 6 - 6. [Full Text]
|
|
|
|
 |
|
 Statins for Patients with Nonischemic Heart Failure? Journal Watch (General), February 17, 2006; 2006(217): 7 - 7. [Full Text]
|
|
|
|
|
|
K. Ramasubbu and D. L. Mann The Emerging Role of Statins in the Treatment of Heart Failure J. Am. Coll. Cardiol., January 17, 2006; 47(2): 342 - 344. [Full Text] [PDF]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
