CLINICAL RESEARCH: HEART FAILURE
Atorvastatin Improves Left Ventricular Systolic Function and Serum Markers of Inflammation in Nonischemic Heart Failure
Srikanth Sola, MD*,
Muhammad Q.S. Mir, MD*,
Stamatios Lerakis, MD, FACC,
Neeraj Tandon, MD, FACC and
Bobby V. Khan, MD, PhD*,*
* Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia
Division of Cardiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Manuscript received March 24, 2005;
revised manuscript received June 6, 2005,
accepted June 14, 2005.
* Reprint requests and correspondence to: Dr. Bobby V. Khan, Division of Cardiology, Department of Medicine, Emory University School of Medicine, 69 Jesse Hill Drive SE, C233, Atlanta, Georgia 30303. (Email: bkhan{at}emory.edu).
OBJECTIVES: This study examined the effect of statin therapy on vascular markers of inflammation and echocardiographic findings in patients with nonischemic forms of cardiomyopathy.
BACKGROUND: Despite advances in therapy, morbidity and mortality from heart failure (HF) remain high. We wished to determine whether treatment with atorvastatin affects left ventricular (LV) systolic function and markers of inflammation in patients with nonischemic HF.
METHODS: A total of 108 patients with nonischemic HF and a left ventricular ejection fraction (LVEF)  35% were randomized to either atorvastatin 20 mg/day or placebo in a double-blinded fashion for a 12-month period. The LVEF and LV end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) were determined by echocardiography. Serum markers of inflammation and oxidation were also measured.
RESULTS: The LVEF increased from 0.33 ± 0.05 to 0.37 ± 0.04 (p = 0.01) in the atorvastatin group over the 12-month follow-up period, whereas those patients in the placebo group experienced a decline in ejection fraction during the same time period. In addition, LVEDD was reduced from 57.1 ± 5.9 mm to 53.4 ± 5.1 mm (p = 0.007) and LVESD was reduced from 42.4 ± 3.8 mm to 39.1 ± 3.8 mm (p = 0.02) in the cohort of patients treated with atorvastatin; these dimensions increased in the placebo group. There was an increase in erythrocyte superoxide dismutase (E-SOD) activity, and there were significant reductions in serum levels of high sensitivity C-reactive protein, interleukin-6 (IL-6), and tumor necrosis factor-alpha receptor II (TNF- RII) in the atorvastatin group.
CONCLUSIONS: The use of atorvastatin in patients with nonischemic HF improves LVEF and attenuates adverse LV remodeling. The effects on soluble levels of several inflammatory markers with atorvastatin suggest, in part, mechanisms by which statins might exert their beneficial effects in nonischemic HF.
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Abbreviations and Acronyms
| | CAD = coronary artery disease | | E-SOD = erythrocyte superoxide dismutase | | HDL = high-density lipoprotein | | HF = heart failure | | hsCRP = high sensitivity C-reactive protein | | IL = interleukin | | LDL = low-density lipoprotein | | LV = left ventricle/ventricular | | LVEDD = left ventricular end-diastolic diameter | | LVEF = left ventricular ejection fraction | | LVESD = left ventricular end-systolic diameter | | TNF- RII = tumor necrosis factor-alpha receptor II |
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