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J Am Coll Cardiol, 2006; 47:2180-2186, doi:10.1016/j.jacc.2005.12.072 (Published online 12 May 2006).
© 2006 by the American College of Cardiology Foundation
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CLINICAL RESEARCH: MYOCARDIAL INFARCTION

Effect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction

Robert L. McNamara, MD, MHS*, Yongfei Wang, MS*, Jeph Herrin, PhD*, Jeptha P. Curtis, MD*, Elizabeth H. Bradley, PhD{dagger}, David J. Magid, MD, MPH§,||, Eric D. Peterson, MD, MPH, Martha Blaney, PharmD#,1, Paul D. Frederick, PhD**, Harlan M. Krumholz, MD, SM*,{dagger},{ddagger},{dagger}{dagger},* for the NRMI Investigators

* Department of Medicine, Section of Cardiovascular Medicine
{dagger} Department of Epidemiology and Public Health, Section of Health Policy and Administration
{ddagger} Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine, New Haven, Connecticut
§ Clinical Research Unit, Kaiser Permanente, Denver, Colorado
|| Departments of Emergency Medicine and Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado
Duke Clinical Research Institute, Duke University, Durham, North Carolina
# Genentech Inc., South San Francisco, California
** Ovation Research Group, Seattle, Washington
{dagger}{dagger} Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut

Manuscript received August 2, 2005; revised manuscript received December 15, 2005, accepted December 19, 2005.

* Reprint requests and correspondence: Dr. Harlan M. Krumholz, Yale University School of Medicine, 333 Cedar Street, PO Box 208088, New Haven, Connecticut 06520. (Email: harlan.krumholz{at}yale.edu).

OBJECTIVES: We sought to determine the effect of door-to-balloon time on mortality for patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).

BACKGROUND: Studies have found conflicting results regarding this relationship.

METHODS: We conducted a cohort study of 29,222 STEMI patients treated with PCI within 6 h of presentation at 395 hospitals that participated in the National Registry of Myocardial Infarction (NRMI)-3 and -4 from 1999 to 2002. We used hierarchical models to evaluate the effect of door-to-balloon time on in-hospital mortality adjusted for patient characteristics in the entire cohort and in different subgroups of patients based on symptom onset-to-door time and baseline risk status.

RESULTS: Longer door-to-balloon time was associated with increased in-hospital mortality (mortality rate of 3.0%, 4.2%, 5.7%, and 7.4% for door-to-balloon times of ≤90 min, 91 to 120 min, 121 to 150 min, and >150 min, respectively; p for trend <0.01). Adjusted for patient characteristics, patients with door-to-balloon time >90 min had increased mortality (odds ratio 1.42; 95% confidence interval [CI] 1.24 to 1.62) compared with those who had door-to-balloon time ≤90 min. In subgroup analyses, increasing mortality with increasing door-to-balloon time was seen regardless of symptom onset-to-door time (≤1 h, >1 to 2 h, >2 h) and regardless of the presence or absence of high-risk factors.

CONCLUSIONS: Time to primary PCI is strongly associated with mortality risk and is important regardless of time from symptom onset to presentation and regardless of baseline risk of mortality. Efforts to shorten door-to-balloon time should apply to all patients.

Abbreviations and Acronyms
  ACC = American College of Cardiology
  AHA = American Heart Association
  AMI = acute myocardial infarction
  CI = confidence interval
  ECG = electrocardiogram
  NRMI = National Registry of Myocardial Infarction
  PCI = percutaneous coronary intervention
  STEMI = ST-segment elevation myocardial infarction




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