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CLINICAL RESEARCH: HEART RHYTHM DISORDERS

Electrogram Characteristics in Postinfarction Ventricular Tachycardia

Effect of Infarct Age

Frank Bogun, MD^_*,_*, Subramaniam Krishnan, MD, Mukarram Siddiqui, MD, Eric Good, DO^_*, Joseph E. Marine, MD, Claudio Schuger, MD, Hakan Oral, MD^_*, Aman Chugh, MD^_*, Frank Pelosi, MD^_* and Fred Morady, MD^_*

^_* University of Michigan Medical Center, Ann Arbor, Michigan
Henry Ford Hospital, Division of Cardiology, Detroit, Michigan

Manuscript received October 11, 2004; revised manuscript received January 6, 2005, accepted January 25, 2005.

^_* Reprint requests and correspondence: Dr. Frank Bogun, Division of Cardiology, University of Michigan Health System, 3119 TC, 1500 E. Medical Center Dr., Ann Arbor, Michigan 48109-0366 (Email: fbogun{at}umich.edu).

OBJECTIVES: The purpose of this study was to correlate infarct age with characteristics of the endocardial electrograms (EGM) obtained in patients undergoing mapping procedures for postinfarction ventricular tachycardia (VT).

BACKGROUND: Experimental studies have demonstrated that infarct age influences EGM duration in the subepicardial left ventricle (LV). The relationship between infarct age and endocardial EGM characteristics has not been investigated in patients with postinfarction VT.

METHODS: In a consecutive series of 23 patients with a history of remote infarction (range 1 to 31 years) and VT, endocardial LV mapping was performed with an electroanatomical mapping system (CARTO, Biosense Webster Inc., Diamond Bar, California) during sinus rhythm. Electrogram morphology and width were analyzed and correlated with infarct age. Isthmus sites of the VT re-entry circuits were identified by entrainment mapping and related to the results of substrate mapping.

RESULTS: There was a significant correlation between infarct age and width of the bipolar endocardial EGM during baseline rhythm in the peri-infarct zone (r = 0.84; p < 0.0001). Increasing infarct age was associated with progressive activation delays in the scar and with isolated potentials separated by an isoelectric interval, the duration of which also correlated with infarct age (r = 0.77; p < 0.001). Among all endocardial sites, the VT isthmus sites displayed the most delay and broadest EGMs during sinus rhythm.

CONCLUSIONS: The presence of broad, fractionated EGMs and isolated potentials indicates a healed myocardial infarction; the older the infarction, the broader the EGM width. Remodeling over time alters the electrophysiologic properties of the peri-infarct tissue.

Abbreviations and Acronyms   EGM = electrogram   LV = left ventricle/ventricular   MI = myocardial infarction   RV = right ventricular   VT = ventricular tachycardia

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Helmut U. Klein and Sven Reek
JACC 2005 46: 675-677. [Full Text]  

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