HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: j.jacc.2005.06.078v1 46/10/1864    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (35) Citing Articles via Google Scholar Google Scholar Articles by Ruano, J. Articles by Pérez Jiménez, F. Search for Related Content PubMed PubMed Citation Articles by Ruano, J. Articles by Pérez Jiménez, F.

CLINICAL RESEARCH: ATHEROSCLEROSIS

Phenolic Content of Virgin Olive Oil Improves Ischemic Reactive Hyperemia in Hypercholesterolemic Patients

Department of Medicine, University of Cordoba, Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Cordoba, Spain.

Manuscript received February 27, 2005; revised manuscript received June 20, 2005, accepted June 27, 2005.

^_* Reprint requests and correspondence: Dr. Francisco Pérez Jiménez, Unidad de Lípidos y Arteriosclerosis, Hospital Universitario Reina Sofía, Avda. Menéndez Pidal, s/n, 14004 Córdoba, España. (Email: fperezjimenez{at}uco.es).

OBJECTIVES: The goal of this study was to evaluate the effects of the phenolic content of virgin olive oil on endothelial reactivity.

BACKGROUND: Endothelial-dependent vasodilatation is impaired during the postprandial state, and oxidative stress could play a key role in its development.

METHODS: Twenty-one hypercholesterolemic volunteers received two breakfasts, using a randomized sequential crossover design. Both arms received the same olive oil, but one had its phenolic acid content reduced from 400 to 80 ppm. Ischemic reactive hyperemia (IRH) was measured with a laser-Doppler procedure at baseline and 2 h and 4 h after oil intake. Postprandial plasma concentrations of lipid fractions, lipoperoxides (LPO), 8-epi prostaglandin-F₂, and nitrates/nitrites (NO_(x)) were obtained at baseline and after 2 h of the fat meal.

RESULTS: The intake of the polyphenol-rich breakfast was associated with an improvement in endothelial function, as well as a greater increase in concentrations of NO_(x) (p < 0.001) and a lower increase in LPO (p < 0.005) and 8-epi prostaglandin-F₂ (p < 0.001) than the ones induced by the low polyphenol fat meal. A positive correlation was found to exist between NO_(x) and enhanced endothelial function at the second hour (r = 0.669; p < 0.01). Furthermore, a negative correlation was found between IRH and LPO (r = –0.203; p < 0.05) and 8-epi prostaglandin-F₂ levels (r = –0.440; p < 0.05).

CONCLUSIONS: A meal containing high-phenolic virgin olive oil improves ischemic reactive hyperemia during the postprandial state. This phenomenon might be mediated via reduction in oxidative stress and the increase of nitric oxide metabolites.

Abbreviations and Acronyms   AUC = area under the curve   HDL-C = high-density lipoprotein cholesterol   IRH = ischemic reactive hyperemia   LDL-C = low-density lipoprotein cholesterol   LPO = lipoperoxides   NO(x) = nitrates/nitrites   TC = total cholesterol   TG = triglycerides   TRL = triglyceride-rich lipoproteins   8-epi-F2 = 8-epi prostaglandin-F2

This article has been cited by other articles:

				J. Delgado-Lista, J. Lopez-Miranda, B. Cortes, P. Perez-Martinez, A. Lozano, R. Gomez-Luna, P. Gomez, M. J. Gomez, J. Criado, F. Fuentes, et al. Chronic dietary fat intake modifies the postprandial response of hemostatic markers to a single fatty test meal Am. J. Clinical Nutrition, February 1, 2008; 87(2): 317 - 322. [Abstract] [Full Text] [PDF]

				J. Ruano, J. Lopez-Miranda, R. de la Torre, J. Delgado-Lista, J. Fernandez, J. Caballero, M. I. Covas, Y. Jimenez, P. Perez-Martinez, C. Marin, et al. Intake of phenol-rich virgin olive oil improves the postprandial prothrombotic profile in hypercholesterolemic patients Am. J. Clinical Nutrition, August 1, 2007; 86(2): 341 - 346. [Abstract] [Full Text] [PDF]

				M. Pfeuffer and J. Schrezenmeir Addition of milk prevents vascular protective effects of tea Eur. Heart J., May 2, 2007; 28(10): 1265 - 1266. [Full Text] [PDF]

				S. J. Rietjens, A. Bast, J. de Vente, and G. R. M. M. Haenen The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress-induced impairment of the NObullet response of isolated rat aorta Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1931 - H1936. [Abstract] [Full Text] [PDF]

				H. Shapiro, P. Singer, Z. Halpern, and R. Bruck Polyphenols in the treatment of inflammatory bowel disease and acute pancreatitis Gut, March 1, 2007; 56(3): 426 - 436. [Full Text] [PDF]

				I. G.E. Zarraga and E. R. Schwarz Impact of Dietary Patterns and Interventions on Cardiovascular Health Circulation, August 29, 2006; 114(9): 961 - 973. [Full Text] [PDF]

				T. Gori Olive Oil and Ischemic Reactive Hyperemia in Hypercholesterolemic Patients J. Am. Coll. Cardiol., July 18, 2006; 48(2): 414 - 414. [Full Text] [PDF]

				D. Giugliano and K. Esposito Virgin Olive Oil and Vegetables Improve Endothelial Health J. Am. Coll. Cardiol., July 18, 2006; 48(2): 413 - 414. [Full Text] [PDF]

				J. Ruano, J. Lopez-Miranda, and F. Perez-Jimenez Reply J. Am. Coll. Cardiol., July 18, 2006; 48(2): 414 - 415. [Full Text] [PDF]