|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 2005; 46:101-105, doi:10.1016/j.jacc.2005.03.045 © 2005 by the American College of Cardiology Foundation |
,*
* University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom
Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
Cardiac Unit, Institute of Child Health, University College London, London, United Kingdom
Manuscript received October 25, 2004; revised manuscript received February 9, 2005, accepted March 10, 2005.
* Reprint requests and correspondence: Dr. Stefan Neubauer, University of Oxford Centre for Clinical Magnetic Resonance Research, University Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom (Email: stefan.neubauer{at}cardiovascular-medicine.ox.ac.uk).
OBJECTIVES: We aimed to test the diagnostic accuracy of cardiovascular magnetic resonance (CMR) imaging in distinguishing pathological left ventricular non-compaction (LVNC) from lesser degrees of trabecular layering seen in healthy volunteers and, in those with cardiomyopathies and concentric left ventricular hypertrophy, potential differential diagnoses. We hypothesized that pathological trabeculation could be distinguished by determining the ratio of non-compacted to compacted myocardium (NC/C ratio).
BACKGROUND: Left ventricular non-compaction is characterized by a non-compacted myocardial layer in the left ventricle. Cardiovascular magnetic resonance images this layer with unprecedented quality, particularly in the ventricular apex, where echocardiography has inherent difficulties.
METHODS: We analyzed magnetic resonance cine images, using the 17-segment model in 45 healthy volunteers, 25 athletes, 39 patients with hypertrophic cardiomyopathy and 14 with dilated cardiomyopathy, 17 with hypertensive heart disease, and 30 with aortic stenosis, as well as images from 7 patients previously diagnosed with LVNC whose diagnoses were supported by additional features.
RESULTS: Areas of non-compaction were common and occurred more frequently in all groups studied in apical and lateral, rather than in basal or septal, segments. A NC/C ratio of >2.3 in diastole distinguished pathological non-compaction, with values for sensitivity, specificity, and positive and negative predictions of 86%, 99%, 75%, and 99%, respectively.
CONCLUSIONS: Left ventricular non-compaction is diagnosed accurately with CMR using the NC/C ratio in diastole.
| |||||||
This article has been cited by other articles:
|
|
 |
|
  H. Ashikaga, B. A. Coppola, K. G. Yamazaki, F. J. Villarreal, J. H. Omens, and J. W. Covell Changes in regional myocardial volume during the cardiac cycle: implications for transmural blood flow and cardiac structure Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H610 - H618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Epstein, J. P. DiMarco, K. A. Ellenbogen, N.A. M. Estes III, R. A. Freedman, L. S. Gettes, A. M. Gillinov, G. Gregoratos, S. C. Hammill, D. L. Hayes, et al. ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons J. Am. Coll. Cardiol., May 27, 2008; 51(21): e1 - e62. [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Epstein, J. P. DiMarco, K. A. Ellenbogen, N.A. M. Estes III, R. A. Freedman, L. S. Gettes, A. M. Gillinov, G. Gregoratos, S. C. Hammill, D. L. Hayes, et al. ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons Circulation, May 27, 2008; 117(21): e350 - e408. [Full Text] [PDF]
|
|
|
|
 |
|
 O. Tufekcioglu, D. Aras, A. Yildiz, S. Topaloglu, and O. Maden Myocardial contraction properties along the long and short axes of the left ventricle in isolated left ventricular non-compaction: pulsed tissue Doppler echocardiography Eur J Echocardiogr, May 1, 2008; 9(3): 344 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Germans, A. A.M. Wilde, and A. C. van Rossum Non-compaction: a distinct cardiomyopathy or non-specific morphological trait? Eur. Heart J., April 1, 2008; 29(7): 949 - 950. [Full Text] [PDF]
|
|
|
|
|
|
D. Dooijes Non-compaction: a distinct cardiomyopathy or non-specific morphological trait?: reply Eur. Heart J., April 1, 2008; 29(7): 950 - 951. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Germans and A. C van Rossum The use of cardiac magnetic resonance imaging to determine the aetiology of left ventricular disease and cardiomyopathy Heart, April 1, 2008; 94(4): 510 - 518. [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Dodd and R. C. Cury Reply Am. J. Roentgenol., April 1, 2008; 190(4): W274 - W274. [Full Text] [PDF]
|
|
|
|
|
|
S. K. Kohli, A. A. Pantazis, J. S. Shah, B. Adeyemi, G. Jackson, W. J. McKenna, S. Sharma, and P. M. Elliott Diagnosis of left-ventricular non-compaction in patients with left-ventricular systolic dysfunction: time for a reappraisal of diagnostic criteria? Eur. Heart J., January 1, 2008; 29(1): 89 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Anderson Ventricular non-compaction a frequently ignored finding? Eur. Heart J., January 1, 2008; 29(1): 10 - 11. [Full Text] [PDF]
|
|
|
|
|
|
T. D. Karamitsos, J. R. Arnold, S. Neubauer, and S. E. Petersen Redefining cardiomyopathies: the role of cardiovascular magnetic resonance imaging Eur. Heart J., December 2, 2007; 28(24): 3094 - 3095. [Full Text] [PDF]
|
|
|
|
|
|
J. D. Dodd, G. Holmvang, U. Hoffmann, M. Ferencik, S. Abbara, T. J. Brady, and R. C. Cury Quantification of Left Ventricular Noncompaction and Trabecular Delayed Hyperenhancement with Cardiac MRI: Correlation with Clinical Severity Am. J. Roentgenol., October 1, 2007; 189(4): 974 - 980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Pastor, J. I. Aramendi, M. Luis, R. Voces, M. A. Rodriguez, and J. M. Galdeano Isolated Pseudohypoplasia of the Right Ventricle Ann. Thorac. Surg., August 1, 2007; 84(2): 668 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Jenni, E N Oechslin, and B van der Loo Isolated ventricular non-compaction of the myocardium in adults Heart, January 1, 2007; 93(1): 11 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lilje, V. Razek, J. J. Joyce, T. Rau, B. F. Finckh, F. Weiss, C. R. Habermann, J. C. Rice, and J. Weil Complications of non-compaction of the left ventricular myocardium in a paediatric population: a prospective study Eur. Heart J., August 1, 2006; 27(15): 1855 - 1860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Stollberger and J. Finsterer Left Ventricular Noncompaction, Cardiac Magnetic Resonance Imaging, and Neuromuscular Disorders J. Am. Coll. Cardiol., March 21, 2006; 47(6): 1233 - 1234. [Full Text] [PDF]
|
|
|
|
|
|
S. E. Petersen, J. B. Selvanayagam, F. Wiesmann, M. D. Robson, J. M. Francis, R. H. Anderson, H. Watkins, and S. Neubauer Reply J. Am. Coll. Cardiol., March 21, 2006; 47(6): 1234 - 1235. [Full Text] [PDF]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
