JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
QUICK SEARCH:   [advanced]


     

J Am Coll Cardiol, 2005; 45:589-594, doi:10.1016/j.jacc.2004.10.061
© 2005 by the American College of Cardiology Foundation
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (14)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morita, H.
Right arrow Articles by Imaizumi, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morita, H.
Right arrow Articles by Imaizumi, T.

CLINICAL RESEARCH: SMOKING AND PLATELET FUNCTION

Only two-week smoking cessation improves platelet aggregability and intraplatelet redox imbalance of long-term smokers

Hirohiko Morita, MD, Hisao Ikeda, MD, PhD*, Nobuya Haramaki, MD, PhD, Hiroyuki Eguchi, MD, PhD and Tsutomu Imaizumi, MD, PhD, FACC

Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan

Manuscript received August 7, 2004; revised manuscript received September 23, 2004, accepted October 20, 2004.

* Reprint requests and correspondence: Dr. Hisao Ikeda, Department of Internal Medicine III, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan (Email: ikeda_hisao{at}kurume-u.ac.jp).

OBJECTIVES: We investigated whether and how soon smoking cessation ameliorates the smoking-induced intracellular oxidative stress and platelet aggregability in long-term smokers.

BACKGROUND: Smoking is a major risk factor of atherothrombosis. Smoking cessation reduces cardiac events. However, the underlying mechanisms of the beneficial effects remain to be elucidated.

METHODS: Twenty-seven male long-term smokers were divided into two groups. Group A (n = 14) quit smoking for four weeks whereas group B (n = 13) resumed smoking two weeks after quitting. Smoking status was monitored by measurement of urinary cotinine. Using gel-filtered platelets, agonist (adenosine diphosphate and collagen)-induced platelet aggregation, platelet-derived nitric oxide (PDNO), intraplatelet nitrotyrosine production, intraplatelet levels of the reduced form of glutathione (GSH) and its oxidized form (GSSG), and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and urinary 8-iso-prostaglandin F2{alpha} (8-iso-PGF2{alpha}), as markers of systemic oxidative stress, were measured. The baseline measurements were similar between the two groups.

RESULTS: Smoking cessation quickly reduced agonist-induced platelet aggregations, intraplatelet nitrotyrosine level, and urinary productions of 8-OHdG and 8-iso-PGF2{alpha} by two weeks in both groups. In group A, they were maintained at the low levels until four weeks, whereas they were reversed by resmoking in group B; PDNO release and intraplatelet GSH/GSSG ratio were time-dependently increased by smoking cessation but reversed by resmoking.

CONCLUSIONS: The present findings are the first demonstration that only two weeks of smoking cessation can ameliorate the enhanced platelet aggregability and intraplatelet redox imbalance in long-term smokers, possibly by decreasing oxidative stress. Our findings may strengthen the motivation for smokers to quit smoking.

Abbreviations and Acronyms
  ADP = adenosine diphosphate
  GSH = reduced form of glutathione
  GSSG = oxidized form of glutathione
  NO = nitric oxide
  PDNO = platelet-derived nitric oxide
  PRP = platelet-rich plasma
  PPP = platelet-poor plasma
  8-iso-PGF2{alpha} = 8-iso-prostaglandin F2{alpha}
  8-OHdG = 8-hydroxy-2'-deoxyguanosine




This article has been cited by other articles:


Home page
 Neuro OncolHome page
M. A. Brockmann, A. Giese, K. Mueller, F. j. Kaba, F. Lohr, C. Weiss, S. Gottschalk, I. Nolte, J. Leppert, J. Tuettenberg, et al.
Preoperative thrombocytosis predicts poor survival in patients with glioblastoma
Neuro-oncol, July 1, 2007; 9(3): 335 - 342.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
F. Barone-Adesi, L. Vizzini, F. Merletti, and L. Richiardi
Short-term effects of Italian smoking regulation on rates of hospital admission for acute myocardial infarction
Eur. Heart J., October 2, 2006; 27(20): 2468 - 2472.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. Hermann, H. Krum, and F. Ruschitzka
To the Heart of the Matter: Coxibs, Smoking, and Cardiovascular Risk
Circulation, August 16, 2005; 112(7): 941 - 945.
[Full Text] [PDF]

Home page
 Journal Watch CardiologyHome page
Smoking Cessation Improves Platelet Function in Just Two Weeks
Journal Watch Cardiology, March 25, 2005; 2005(325): 7 - 7.
[Full Text]


HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
Copyright © 2005 by the American College of Cardiology Foundation.