JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
 QUICK SEARCH:   [advanced]


     


J Am Coll Cardiol, 2005; 45:1753-1756, doi:10.1016/j.jacc.2004.10.079
© 2005 by the American College of Cardiology Foundation
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (51)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ajzenberg, N.
Right arrow Articles by Steg, Ph. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ajzenberg, N.
Right arrow Articles by Steg, Ph. G.
Related Collections
Right arrowRelated Article

CLINICAL RESEARCH: INTERVENTIONAL CARDIOLOGY

Enhanced Shear-Induced Platelet Aggregation in Patients Who Experience Subacute Stent Thrombosis

A Case-Control Study

Nadine Ajzenberg, MD, PhD*,*, Pierre Aubry, MD{dagger}, Marie-Genevieve Huisse, MD*, Agnés Cachier, MD{dagger}, Walid El Amara, MD{dagger}, Laurent J. Feldman, MD, PhD{dagger}, Dominique Himbert, MD{dagger}, Dominique Baruch, MD, PhD{ddagger}, Marie-Claude Guillin, MD, PhD* and Ph. Gabriel Steg, MD{dagger}

* Hématologie et Immunologie, Paris, France
{dagger} Cardiologie, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France
{ddagger} Hôpital de Bicêtre, Le Kremlin Bicêtre, France

Manuscript received September 3, 2004; revised manuscript received October 11, 2004, accepted October 18, 2004.

* Reprint requests and correspondence to: Dr. Nadine Ajzenberg, Service d’Hématologie et Immunologie, Hôpital Bichat-Claude Bernard, 46 rue Henri Huchard, 75877 Paris Cedex 18, France. (Email: nadine.ajzenberg{at}bch.ap-hop-paris.fr).

OBJECTIVES: The goal of this study was to identify differences in shear-induced platelet aggregation (SIPA) between patients who did or did not experience subacute stent thrombosis (SAT).

BACKGROUND: Despite dual antiplatelet therapy, SAT after coronary stenting occurs in approximately 1% of patients. There is no accepted platelet function test to identify patients at risk.

METHODS: We analyzed platelet aggregation in 10 patients who had experienced SAT (cases), 22 stented patients without SAT (controls), and 17 healthy volunteers (normals). All patients except normals were treated with both aspirin and clopidogrel.

RESULTS: Shear-induced platelet aggregation was higher in cases than in controls at both shear rates of 200 s–1 (40.9 ± 12.2% vs. 18.2 ± 18%, p = 0.013) and 4,000 s–1 (57.4 ± 16.4% vs. 23.4 ± 21.2%, p = 0.009). Moreover, SIPA in cases was significantly higher than in normals both at 200 s–1 (p = 0.013) and 4,000–1 (p = 0.009).

CONCLUSIONS: Shear-induced platelet aggregation is increased in patients experiencing SAT compared with controls receiving dual antiplatelet therapy and to normals receiving no antiplatelet therapy, which suggests increased intrinsic patient-related platelet reactivity in patients with SAT. The predictive value of SIPA for SAT requires prospective investigation.

Abbreviations and Acronyms
  ADP = adenosine diphosphate
  DSP = disappearance of single platelets
  PCI = percutaneous coronary intervention
  PRP = platelet-rich plasma
  SAT = subacute stent thrombosis
  SIPA = shear-induced platelet aggregation
  vWF = von Willebrand factor


Related Article

Resistance to Antiplatelet Resistance: Is it Justified?
Steven R. Steinhubl, Richard Charnigo, and David J. Moliterno
J. Am. Coll. Cardiol. 2005 45: 1757-1758. [Full Text] [PDF]



This article has been cited by other articles:


Home page
Anesth. Analg.Home page
L. T. Newsome, M. A. Kutcher, and R. L. Royster
Coronary Artery Stents: Part I. Evolution of Percutaneous Coronary Intervention
Anesth. Analg., August 1, 2008; 107(2): 552 - 569.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
D. Trenk, W. Hochholzer, M. F. Fromm, L.-E. Chialda, A. Pahl, C. M. Valina, C. Stratz, P. Schmiebusch, H.-P. Bestehorn, H. J. Buttner, et al.
Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents
J. Am. Coll. Cardiol., May 20, 2008; 51(20): 1925 - 1934.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart J SupplHome page
J.-P. Bassand
Unmet needs in antiplatelet therapy
Eur. Heart J. Suppl., May 1, 2008; 10(suppl_D): D3 - D11.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart J SupplHome page
L. Wallentin
Dual antiplatelet therapy in the drug-eluting stent era
Eur. Heart J. Suppl., May 1, 2008; 10(suppl_D): D38 - D44.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
P. L. L'Allier, G. Ducrocq, N. Pranno, S. Noble, R. Ibrahim, J. C. Gregoire, F. Azzari, A. Nozza, C. Berry, S. Doucet, et al.
Clopidogrel 600-mg double loading dose achieves stronger platelet inhibition than conventional regimens: results from the PREPAIR randomized study.
J. Am. Coll. Cardiol., March 18, 2008; 51(11): 1066 - 1072.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
P. A. Gurbel, R. C. Becker, K. G. Mann, S. R. Steinhubl, and A. D. Michelson
Platelet Function Monitoring in Patients With Coronary Artery Disease
J. Am. Coll. Cardiol., November 6, 2007; 50(19): 1822 - 1834.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
S. Windecker and B. Meier
Late Coronary Stent Thrombosis
Circulation, October 23, 2007; 116(17): 1952 - 1965.
[Full Text] [PDF]


Home page
J Am Coll CardiolHome page
G. Campo, M. Valgimigli, D. Gemmati, G. Percoco, L. Catozzi, A. Frangione, F. Federici, F. Ferrari, M. Tebaldi, S. Luccarelli, et al.
Poor Responsiveness to Clopidogrel: Drug-Specific or Class-Effect Mechanism?: Evidence From a Clopidogrel-to-Ticlopidine Crossover Study
J. Am. Coll. Cardiol., September 18, 2007; 50(12): 1132 - 1137.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
A. O. Maree and D. J. Fitzgerald
Variable Platelet Response to Aspirin and Clopidogrel in Atherothrombotic Disease
Circulation, April 24, 2007; 115(16): 2196 - 2207.
[Full Text] [PDF]


Home page
J Am Coll CardiolHome page
D. J. Angiolillo, A. Fernandez-Ortiz, E. Bernardo, F. Alfonso, C. Macaya, T. A. Bass, and M. A. Costa
Variability in Individual Responsiveness to Clopidogrel: Clinical Implications, Management, and Future Perspectives
J. Am. Coll. Cardiol., April 10, 2007; 49(14): 1505 - 1516.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
D. J. Angiolillo, S. B. Shoemaker, B. Desai, H. Yuan, R. K. Charlton, E. Bernardo, M. M. Zenni, L. A. Guzman, T. A. Bass, and M. A. Costa
Randomized Comparison of a High Clopidogrel Maintenance Dose in Patients With Diabetes Mellitus and Coronary Artery Disease: Results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) Study
Circulation, February 13, 2007; 115(6): 708 - 716.
[Abstract] [Full Text] [PDF]


Home page
ASH Education BookHome page
D. J. Fitzgerald and A. Maree
Aspirin and Clopidogrel Resistance
Hematology, January 1, 2007; 2007(1): 114 - 120.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
G. Campo, M. Valgimigli, D. Gemmati, G. Percoco, S. Tognazzo, G. Cicchitelli, L. Catozzi, P. Malagutti, M. Anselmi, C. Vassanelli, et al.
Value of Platelet Reactivity in Predicting Response to Treatment and Clinical Outcome in Patients Undergoing Primary Coronary Intervention: Insights Into the STRATEGY Study
J. Am. Coll. Cardiol., December 5, 2006; 48(11): 2178 - 2185.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
W. Hochholzer, D. Trenk, H.-P. Bestehorn, B. Fischer, C. M. Valina, M. Ferenc, M. Gick, A. Caputo, H. J. Buttner, and F.-J. Neumann
Impact of the Degree of Peri-Interventional Platelet Inhibition After Loading With Clopidogrel on Early Clinical Outcome of Elective Coronary Stent Placement
J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1742 - 1750.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart J SupplHome page
J.-P. Collet and G. Montalescot
Premature withdrawal and alternative therapies to dual oral antiplatelet therapy
Eur. Heart J. Suppl., October 1, 2006; 8(suppl_G): G46 - G52.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
D. J. Angiolillo, A. Fernandez-Ortiz, E. Bernardo, C. Ramirez, M. Sabate, P. Jimenez-Quevedo, R. Hernandez, R. Moreno, J. Escaned, F. Alfonso, et al.
Clopidogrel Withdrawal Is Associated With Proinflammatory and Prothrombotic Effects in Patients With Diabetes and Coronary Artery Disease
Diabetes, March 1, 2006; 55(3): 780 - 784.
[Abstract] [Full Text] [PDF]


Home page
Clin. Chem.Home page
B. T. Ivandic, P. Schlick, P. Staritz, K. Kurz, H. A. Katus, and E. Giannitsis
Determination of Clopidogrel Resistance by Whole Blood Platelet Aggregometry and Inhibitors of the P2Y12 Receptor
Clin. Chem., March 1, 2006; 52(3): 383 - 388.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
A. N. DeMaria, O. Ben-Yehuda, D. Berman, G. K. Feld, G. S. Ginsburg, B. H. Greenberg, W. Y.W. Lew, D. Sahn, and S. Tsimikas
Highlights of the Year in JACC 2005
J. Am. Coll. Cardiol., January 3, 2006; 47(1): 184 - 202.
[Full Text] [PDF]


Home page
J Am Coll CardiolHome page
S. R. Steinhubl, R. Charnigo, and D. J. Moliterno
Resistance to Antiplatelet Resistance: Is it Justified?
J. Am. Coll. Cardiol., June 7, 2005; 45(11): 1757 - 1758.
[Full Text] [PDF]




HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
Copyright © 2005 by the American College of Cardiology Foundation.