CLINICAL RESEARCH: PLAQUE RUPTURE
Multiple Plaque Rupture and C-Reactive Protein in Acute Myocardial Infarction
Atsushi Tanaka, MD*,*,
Kenei Shimada, MD ,
Toshihiko Sano, MD*,
Masashi Namba, MD*,
Tsunemori Sakamoto, MD*,
Yukio Nishida, MD*,
Takahiko Kawarabayashi, MD*,
Daiju Fukuda, MD and
Junichi Yoshikawa, MD, FACC
* Baba Memorial Hospital, Sakai, Japan
Department of Internal Medicine and Cardiology Graduate School of Medicine, Osaka City University, Osaka, Japan
Manuscript received August 24, 2004;
revised manuscript received December 30, 2004,
accepted January 11, 2005.
* Reprint requests and correspondence: Dr. Atsushi Tanaka, Department of Cardiology, Baba Memorial Hospital, 4-244, Hamadera-funao-cho higashi, Sakai, 592-8555 Japan (Email: m4497147{at}msic.med.osaka-cu.ac.jp).
OBJECTIVES: This study sought to investigate the relationship between multiple plaque ruptures, C-reactive protein (CRP), and clinical prognosis in acute myocardial infarction (AMI).
BACKGROUND: Several studies have demonstrated that ruptured or vulnerable plaques exist not only at the culprit lesion but also in the whole coronary artery in some acute coronary syndrome (ACS) patients. Recent studies have reported that a ruptured plaque at the culprit lesion is associated with elevated CRP, which indicates a poor prognosis in patients with ACS.
METHODS: We performed intravascular ultrasound in 45 infarct-related arteries and another 84 major coronary arteries in 45 first AMI patients.
RESULTS: Plaque rupture was observed in 21 patients (47%) at the culprit site. Intravascular ultrasound revealed 17 additional plaque ruptures at remote sites in 11 patients (24%). Patients with multiple risk factors were more frequently found in our multiple-plaque rupture patients compared with single-plaque rupture or nonrupture patients (82% vs. 40% vs. 29%, p = 0.01). High-sensitive CRP levels had a positive correlation with the number of plaque ruptures (p < 0.01). All culprit lesions were successfully treated by percutaneous coronary intervention. Patients with multiple plaque rupture showed significantly poor prognosis compared with others (p = 0.01).
CONCLUSIONS: Multiple plaque rupture is associated with systemic inflammation, and patients with multiple plaque rupture can be expected to show a poor prognosis. Our results suggest that AMI treatment should focus not only on stabilization of the culprit site but also a systemic approach to systemic stabilization of the arteries.
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Abbreviations and Acronyms
| | ACS = acute coronary syndrome | | AMI = acute myocardial infarction | | hs-CRP = high-sensitivity C-reactive protein | | IVUS = intravascular ultrasound | | PCI = percutaneous coronary intervention |
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