ATHEROSCLEROSIS
Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis
Rajat Deo, MD*,
Amit Khera, MD*,
Darren K. McGuire, MD, MHSc*,
Sabina A. Murphy, MPH ,
Januario de P. Meo Neto, MD ,
David A. Morrow, MD, MPH and
James A. de Lemos, MD*,*
* Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Donald W. Reynolds Cardiovascular Clinical Research Center, Brigham and Women's Hospital, Boston, Massachusetts, USA
INCOR, Sao Paulo, Brazil. USA
Manuscript received March 11, 2004;
revised manuscript received July 4, 2004,
accepted July 28, 2004.
* Reprint requests and correspondence: Dr. James A. de Lemos, Division of Cardiology, UT Southwestern Medical Center, 5909 Harry Hines Boulevard, Room HA9.133, Dallas, Texas 75390-9047 (Email: james.delemos{at}utsouthwestern.edu).
OBJECTIVES: We sought to evaluate the association between plasma levels of monocyte chemoattractant protein (MCP)-1 and the risk for subclinical atherosclerosis.
BACKGROUND: Monocyte chemoattractant protein is a chemokine that recruits monocytes into the developing atheroma and may contribute to atherosclerotic disease development and progression. Plasma levels of MCP-1 are independently associated with prognosis in patients with acute coronary syndromes, but few population-based data are available from subjects in earlier stages of atherosclerosis.
METHODS: In the Dallas Heart Study, a population-based probability sample of adults in Dallas County  65 years old, plasma levels of MCP-1 were measured in 3,499 subjects and correlated with traditional cardiovascular risk factors, high-sensitivityC-reactive protein (hs-CRP), and coronary artery calcium (CAC) measured by electron beam computed tomography.
RESULTS: Higher MCP-1 levels were associated with older age, white race, family history of premature coronary disease, smoking, hypertension, diabetes, hypercholesterolemia, and higher levels of hs-CRP (p < 0.01 for each). Similar associations were observed between MCP-1 and risk factors in the subgroup of participants without detectable CAC. Compared with the subjects in the lowest quartile of MCP-1, the odds of prevalent CAC (CAC score  10) for subjects in the second, third, and fourth quartiles were 1.30 (95% confidence interval [CI] 0.99 to 1.73), 1.60 (95% CI 1.22 to 2.11), and 2.02 (95% CI 1.54 to 2.63), respectively. The association between MCP-1 and CAC remained significant when adjusted for traditional cardiovascular risk factors, but not when further adjusted for age.
CONCLUSIONS: In a large population-based sample, plasma levels of MCP-1 were associated with traditional risk factors for atherosclerosis, supporting the hypothesis that MCP-1 may mediate some of the atherogenic effects of these risk factors. These findings support the potential role of MCP-1 as a biomarker target for drug development.
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Abbreviations and Acronyms
| | CAC = coronary artery calcium | | CAD = coronary artery disease | | EBCT = electron beam computed tomography | | HDL = high-density lipoprotein | | hs-CRP = high-sensitivity C-reactive protein | | LDL = low-density lipoprotein | | LVEF = left ventricular ejection fraction | | MCP = monocyte chemoattractant protein |
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
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|
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|
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|
|
|
|
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112(14):
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|
|
|
|
|
|
|
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25(10):
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|
|
|
|
|
|
|
D. H. McDermott, Q. Yang, S. Kathiresan, L. A. Cupples, J. M. Massaro, J. F. Keaney Jr, M. G. Larson, R. S. Vasan, J. N. Hirschhorn, C. J. O'Donnell, et al.
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112(8):
1113 - 1120.
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|
|
|
|
|
|
|
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46(3):
464 - 469.
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