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J Am Coll Cardiol, 2004; 44:1812-1818, doi:10.1016/j.jacc.2004.07.047
© 2004 by the American College of Cardiology Foundation
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ATHEROSCLEROSIS

Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis

Rajat Deo, MD*, Amit Khera, MD*, Darren K. McGuire, MD, MHSc*, Sabina A. Murphy, MPH{dagger}, Januario de P. Meo Neto, MD{ddagger}, David A. Morrow, MD, MPH{dagger} and James A. de Lemos, MD*,*

* Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
{dagger} Donald W. Reynolds Cardiovascular Clinical Research Center, Brigham and Women's Hospital, Boston, Massachusetts, USA
{ddagger} INCOR, Sao Paulo, Brazil. USA

Manuscript received March 11, 2004; revised manuscript received July 4, 2004, accepted July 28, 2004.

* Reprint requests and correspondence: Dr. James A. de Lemos, Division of Cardiology, UT Southwestern Medical Center, 5909 Harry Hines Boulevard, Room HA9.133, Dallas, Texas 75390-9047 (Email: james.delemos{at}utsouthwestern.edu).

OBJECTIVES: We sought to evaluate the association between plasma levels of monocyte chemoattractant protein (MCP)-1 and the risk for subclinical atherosclerosis.

BACKGROUND: Monocyte chemoattractant protein is a chemokine that recruits monocytes into the developing atheroma and may contribute to atherosclerotic disease development and progression. Plasma levels of MCP-1 are independently associated with prognosis in patients with acute coronary syndromes, but few population-based data are available from subjects in earlier stages of atherosclerosis.

METHODS: In the Dallas Heart Study, a population-based probability sample of adults in Dallas County ≤65 years old, plasma levels of MCP-1 were measured in 3,499 subjects and correlated with traditional cardiovascular risk factors, high-sensitivityC-reactive protein (hs-CRP), and coronary artery calcium (CAC) measured by electron beam computed tomography.

RESULTS: Higher MCP-1 levels were associated with older age, white race, family history of premature coronary disease, smoking, hypertension, diabetes, hypercholesterolemia, and higher levels of hs-CRP (p < 0.01 for each). Similar associations were observed between MCP-1 and risk factors in the subgroup of participants without detectable CAC. Compared with the subjects in the lowest quartile of MCP-1, the odds of prevalent CAC (CAC score ≥10) for subjects in the second, third, and fourth quartiles were 1.30 (95% confidence interval [CI] 0.99 to 1.73), 1.60 (95% CI 1.22 to 2.11), and 2.02 (95% CI 1.54 to 2.63), respectively. The association between MCP-1 and CAC remained significant when adjusted for traditional cardiovascular risk factors, but not when further adjusted for age.

CONCLUSIONS: In a large population-based sample, plasma levels of MCP-1 were associated with traditional risk factors for atherosclerosis, supporting the hypothesis that MCP-1 may mediate some of the atherogenic effects of these risk factors. These findings support the potential role of MCP-1 as a biomarker target for drug development.

Abbreviations and Acronyms
  CAC = coronary artery calcium
  CAD = coronary artery disease
  EBCT = electron beam computed tomography
  HDL = high-density lipoprotein
  hs-CRP = high-sensitivity C-reactive protein
  LDL = low-density lipoprotein
  LVEF = left ventricular ejection fraction
  MCP = monocyte chemoattractant protein




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