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ECHOCARDIOGRAPHY

Evaluation of cardioprotective effects of recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in myocardial ischemia-reperfusion injury by real-time myocardial contrast echocardiography

Alexander Hansen, MD^,*, Anjali Kumar, PhD^*, David Wolf, BS, Kamilla Frankenbergerova, BS, Arthur Filusch, MD, Marie-Luise Gross, MD, Sebastian Mueller, MD, Hugo Katus, MD and Helmut Kuecherer, MD

^* Wyeth Research, Cambridge, Massachusetts, USA
Cardiology
Pathology, University of Heidelberg, Heidelberg, Germany

Manuscript received February 9, 2004; revised manuscript received April 22, 2004, accepted May 2, 2004.

^* Reprint requests and correspondence: Dr. Alexander Hansen, Department of Cardiology, University of Heidelberg, Bergheimerstr. 58, 69115 Heidelberg, Germany (Email: alexander_hansen{at}med.uni-heidelberg.de).

OBJECTIVES: The purpose was to examine the cardioprotective effects of recombinant P-selectin glycoprotein ligand-immunoglobulin (rPSGL-Ig) in ischemia-reperfusion injury by real-time myocardial contrast echocardiography (MCE).

BACKGROUND: P-selectin mediates leukocyte recruitment into areas of inflammation.

METHODS: Sixteen pigs underwent 45 min of left anterior descending coronary artery occlusion followed by reperfusion and received rPSGL-Ig or vehicle. To assess changes in myocardial perfusion (A x ß), MCE was performed.

RESULTS: After 120 min of reperfusion, A x ß in the risk area was higher (0.84 ± 0.15 dB/s vs. 0.28 ± 0.1 dB/s, p < 0.0001), and the infarct size was lower (30.3 ± 12% vs. 57 ± 14%, p = 0.002) in the rPSGL-Ig group compared with the vehicle group.

CONCLUSIONS: Recombinant PSGL-Ig improved postischemic reflow accurately detected by real-time MCE.

Abbreviations and Acronyms   A x ß = myocardial perfusion   FAS = fractional area shortening   LAD = left anterior descending coronary artery   LV = left ventricle   MBF = myocardial blood flow   MCE = myocardial contrast echocardiography   PSGL-1 = P-selectin glycoprotein ligand-1   rPSGL-Ig = recombinant P-selectin glycoprotein ligand-immunoglobulin

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