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J Am Coll Cardiol, 2004; 44:810-819, doi:10.1016/j.jacc.2004.05.055
© 2004 by the American College of Cardiology Foundation
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HEART FAILURE

Multidisciplinary strategies for the management of heart failure patients at high risk for admission

A systematic review of randomized trials

Finlay A. McAlister, MD, MSc, FRCPC*,*, Simon Stewart, PhD, FESC, FAHA{dagger}, Stefania Ferrua, MD{ddagger} and John J.J.V. McMurray, MD, FESC, FACC§

* Division of General Internal Medicine, University of Alberta, Edmonton, Canada
{dagger} Division of Health Sciences, University of South Australia, Adelaide,Australia
{ddagger} Divisione Universitaria di Cardiologia Azienda Ospedaliera San Giovanni Battista Corso Dogliotti, Torino, Italy
§ Department of Cardiology, Western Infirmary, Glasgow, United Kingdom

Manuscript received January 20, 2004; revised manuscript received April 8, 2004, accepted May 11, 2004.

* Reprint requests and correspondence: Dr. Finlay A. McAlister, 2E3.24 WMC, University of Alberta Hospital, 8440 112 Street, Edmonton, Alberta, Canada T6G 2R7 (Email: Finlay.McAlister{at}ualberta.ca).

OBJECTIVES: The aim of this study was to determine whether multidisciplinary strategies improve outcomes for heart failure (HF) patients.

BACKGROUND: Because the prognosis of HF remains poor despite pharmacotherapy, there is increasing interest in alternative models of care delivery for these patients.

METHODS: Randomized trials of multidisciplinary management programs in HF were identified by searching electronic databases and bibliographies and via contact with experts.

RESULTS: Twenty-nine trials (5,039 patients) were identified but were not pooled, because of considerable heterogeneity. A priori, we divided the interventions into homogeneous groups that were suitable for pooling. Strategies that incorporated follow-up by a specialized multidisciplinary team (either in a clinic or a non-clinic setting) reduced mortality (risk ratio [RR] 0.75, 95% confidence interval [CI] 0.59 to 0.96), HF hospitalizations (RR 0.74, 95% CI 0.63 to 0.87), and all-cause hospitalizations (RR 0.81, 95% CI 0.71 to 0.92). Programs that focused on enhancing patient self-care activities reduced HF hospitalizations (RR 0.66, 95% CI 0.52 to 0.83) and all-cause hospitalizations (RR 0.73, 95% CI 0.57 to 0.93) but had no effect on mortality (RR 1.14, 95% CI 0.67 to 1.94). Strategies that employed telephone contact and advised patients to attend their primary care physician in the event of deterioration reduced HF hospitalizations (RR 0.75, 95% CI 0.57 to 0.99) but not mortality (RR 0.91, 95% CI 0.67 to 1.29) or all-cause hospitalizations (RR 0.98, 95% CI 0.80 to 1.20). In 15 of 18 trials that evaluated cost, multidisciplinary strategies were cost-saving.

CONCLUSIONS: Multidisciplinary strategies for the management of patients with HF reduce HF hospitalizations. Those programs that involve specialized follow-up by a multidisciplinary team also reduce mortality and all-cause hospitalizations.

Abbreviations and Acronyms
  CI = confidence interval
  HF = heart failure
  NNT = number needed to treat
  RR = risk ratio




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