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J Am Coll Cardiol, 2004; 44:509-512, doi:10.1016/j.jacc.2004.03.071 © 2004 by the American College of Cardiology Foundation |
* Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, USA
Manuscript received February 6, 2004; revised manuscript received March 19, 2004, accepted March 23, 2004.
* Reprint requests and correspondence: Dr. Carl J. Pepine, Division of Cardiovascular Medicine, University of Florida, 1600 S.W. Archer Road, Gainesville, Florida 32610-0277, USA.
pepincj{at}medicine.ufl.edu
The prevalence of diabetes is increasing, and patients with diabetes are at increased risk of adverse cardiovascular outcomes. Recently, the results from 11 large randomized clinical trials have suggested a difference in the emergence of new diabetes according to cardiovascular medication use. Treatment with angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and calcium antagonists yielded a lower incidence of diabetes development than beta-blockers and diuretics. Physicians should consider this possible diabetes consequence when prescribing long-term beta-blockers and diuretics, particularly in patients at high risk of developing diabetes.
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