This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pepine, C. J. Articles by Cooper-DeHoff, R. M. Search for Related Content PubMed PubMed Citation Articles by Pepine, C. J. Articles by Cooper-DeHoff, R. M.

VIEWPOINT

Cardiovascular therapies and risk for development of diabetes

^* Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, USA

Manuscript received February 6, 2004; revised manuscript received March 19, 2004, accepted March 23, 2004.

^* Reprint requests and correspondence: Dr. Carl J. Pepine, Division of Cardiovascular Medicine, University of Florida, 1600 S.W. Archer Road, Gainesville, Florida 32610-0277, USA.
pepincj{at}medicine.ufl.edu

The prevalence of diabetes is increasing, and patients with diabetes are at increased risk of adverse cardiovascular outcomes. Recently, the results from 11 large randomized clinical trials have suggested a difference in the emergence of new diabetes according to cardiovascular medication use. Treatment with angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and calcium antagonists yielded a lower incidence of diabetes development than beta-blockers and diuretics. Physicians should consider this possible diabetes consequence when prescribing long-term beta-blockers and diuretics, particularly in patients at high risk of developing diabetes.

Abbreviations and Acronyms   ACE = angiotensin-converting enzyme   ARB = angiotensin receptor blocker   BB = beta-blocker   CA = calcium antagonist   CAD = coronary artery disease   CV = cardiovascular   HCTZ = hydrochlorothiazide   HOPE = Heart Outcomes Prevention Evaluation   SCOPE = Study on Cognition and Prognosis in the Elderly   STOP-2 = Swedish Trial in Old Patients with Hypertension-2

This article has been cited by other articles:

				R. M. Cooper-DeHoff, M. A. Pacanowski, and C. J. Pepine Cardiovascular therapies and associated glucose homeostasis: implications across the dysglycemia continuum. J. Am. Coll. Cardiol., February 3, 2009; 53(5 Suppl): S28 - S34. [Abstract] [Full Text] [PDF]

				L. H. Clerk, M. A. Vincent, E. J. Barrett, M. F. Lankford, and J. R. Lindner Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiogensin-converting enzyme inhibition Am J Physiol Endocrinol Metab, December 1, 2007; 293(6): E1804 - E1809. [Abstract] [Full Text] [PDF]

				S. H. Han, M. J. Quon, J.-a Kim, and K. K. Koh Adiponectin and Cardiovascular Disease: Response to Therapeutic Interventions J. Am. Coll. Cardiol., February 6, 2007; 49(5): 531 - 538. [Abstract] [Full Text] [PDF]

				A. Salvetti and L. Ghiadoni Thiazide Diuretics in the Treatment of Hypertension: An Update J. Am. Soc. Nephrol., April 1, 2006; 17(4_suppl_2): S25 - S29. [Abstract] [Full Text] [PDF]

				R. Cooper-DeHoff and C. J. Pepine Ranolazine is associated with cardiovascular and metabolic improvement: a win-win for patients with diabetes Eur. Heart J., January 1, 2006; 27(1): 5 - 6. [Full Text] [PDF]

				S. Nathan, C. J. Pepine, and G. L. Bakris Calcium Antagonists: Effects on Cardio-Renal Risk in Hypertensive Patients Hypertension, October 1, 2005; 46(4): 637 - 642. [Abstract] [Full Text] [PDF]

				M R Abdollahi, T R Gaunt, H E Syddall, C Cooper, D I W Phillips, S Ye, and I N M Day Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits J. Med. Genet., May 1, 2005; 42(5): 396 - 401. [Abstract] [Full Text] [PDF]