|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 2004; 43:1646-1653, doi:10.1016/j.jacc.2003.12.036 © 2004 by the American College of Cardiology Foundation |
* Fondazione Salvatore Maugeri, Istituto di Ricovero e Cura a Carattere Scientifico, Veruno, Italy
Ospedale Civile, Pordenone, Italy
Istituto di Ricerche Farmacologiche "Mario Negri," Milano, Italy
Ospedale Bassini, Cinisello Balsamo, Italy
|| Ospedale S. Matteo, Pavia, Italy
¶ Centro Studi ANMCO, Firenze, Italy
Manuscript received January 28, 2002; revised manuscript received December 6, 2003, accepted December 16, 2003.
* Reprint requests and correspondence: Dr. Pier L. Temporelli, Fondazione "Salvatore Maugeri," IRCCS, Via Revislate, 13, 28010 Veruno (NO), Italy.
ptemporelli{at}fsm.it
OBJECTIVES: The goal of this study was to assess the impact of left ventricular (LV) diastolic filling on remodeling and survival after acute myocardial infarction (AMI).
BACKGROUND: Little is known regarding the link between LV filling, its changes over time, and six-month remodeling and late survival in uncomplicated AMI.
METHODS: Doppler mitral profile, end-diastolic volume index (EDVi) and end-systolic volume index (ESVi), ejection fraction (EF), and wall motion abnormalities (%WMA) were evaluated in 571 patients from the GISSI-3 Echo substudy at baseline, pre-discharge, and six months after AMI. Patients with baseline early mitral deceleration time (DT) 130 ms were assigned to the restrictive group (n = 147), and those with DT >130 ms to the nonrestrictive group (n = 424).
RESULTS: Restrictive group patients had greater baseline ESVi and %WMA and lower EF than nonrestrictive group, and six-month greater LV dilation (EDVi, ESVi: p < 0.001 for EDVi and ESVi), smaller decrease in %WMA decrease (p < 0.01), and larger EF impairment (p < 0.008). Among the restrictive group, patients (n = 56) with pre-discharge persistent restrictive filling (n = 56) showed six-month greater LV enlargement (p < 0.001) and EF impairment (p < 0.009) than those (n = 91) with reversible restrictive filling. Baseline %WMA and EDVi, together with pre-discharge persistent restrictive filling, predicted severe (>20%) LV dilation. Four-year survival was 93% in nonrestrictive patients versus 88% in the restrictive group (p < 0.06), and 93% in pre-discharge reversible restrictive versus 79% in persistent restrictive (p < 0.0003). The single best predictor of mortality, by Cox analysis, was pre-discharge persistent restrictive filling (chi-square 14.88).
CONCLUSIONS: Left ventricular dilation may occur even after uncomplicated AMI and may be paralleled by an improvement in LV filling. However, a baseline restrictive filling that persists at pre-discharge identifies more compromised patients at higher risk for six-month remodeling and four-year mortality.
| ||||||||||||||||||||
This article has been cited by other articles:
|
|
 |
|
  A. Meris, M. Amigoni, H. Uno, J. J. Thune, A. Verma, L. Kober, M. Bourgoun, J. J. McMurray, E. J. Velazquez, A. P. Maggioni, et al. Left atrial remodelling in patients with myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: the VALIANT Echo Study Eur. Heart J., November 11, 2008; (2008) ehn499v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Richardson-Lobbedez, S. Marechaux, C. Bauters, J. Darchis, J. L. Auffray, J. J. Bauchart, J. M. Aubert, T. H. LeJemtel, M. Lesenne, E. Van Belle, et al. Prognostic importance of tissue Doppler-derived diastolic function in patients presenting with acute coronary syndrome: a bedside echocardiographic study Eur J Echocardiogr, September 1, 2008; 9(5): 594 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gelsomino, R. Lorusso, C. Rostagno, S. Caciolli, G. Bille, G. De Cicco, S. Romagnoli, C. Porciani, P. Stefano, and G. F. Gensini Prognostic value of Doppler-derived mitral deceleration time on left ventricular reverse remodelling after undersized mitral annuloplasty Eur J Echocardiogr, September 1, 2008; 9(5): 631 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. V. Ennezat, N. Lamblin, F. Mouquet, O. Tricot, P. Quandalle, V. Aumegeat, O. Equine, O. Nugue, B. Segrestin, P. de Groote, et al. The effect of ageing on cardiac remodelling and hospitalization for heart failure after an inaugural anterior myocardial infarction Eur. Heart J., August 2, 2008; 29(16): 1992 - 1999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. St John Sutton Quest for Diastolic Prognostic Indicators of Clinical Outcome After Acute Myocardial Infarction Circulation, May 20, 2008; 117(20): 2570 - 2572. [Full Text] [PDF]
|
|
|
|
|
|
Meta-Analysis Research Group in Echocardiography ( Independent Prognostic Importance of a Restrictive Left Ventricular Filling Pattern After Myocardial Infarction: An Individual Patient Meta-Analysis: Meta-Analysis Research Group in Echocardiography Acute Myocardial Infarction Circulation, May 20, 2008; 117(20): 2591 - 2598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Moller, C. Torp-Pedersen, and L. V. Kober Is heart failure the critical warning sign for death following myocardial infarction? Eur. Heart J., April 1, 2008; 29(7): 833 - 834. [Full Text] [PDF]
|
|
|
|
|
|
A. Sestili, C. Coletta, V. Manno, S. Perna, M. Renzi, P. Romano, R. Ricci, and V. Ceci Restrictive mitral inflow pattern is a strong independent predictor of lack of viable myocardium after a first acute myocardial infarction Eur J Echocardiogr, October 1, 2007; 8(5): 332 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Kirkpatrick, M. A. Vannan, J. Narula, and R. M. Lang Echocardiography in Heart Failure: Applications, Utility, and New Horizons J. Am. Coll. Cardiol., July 31, 2007; 50(5): 381 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-M. Yu, J. E. Sanderson, T. H. Marwick, and J. K. Oh Tissue Doppler Imaging: A New Prognosticator for Cardiovascular Diseases J. Am. Coll. Cardiol., May 15, 2007; 49(19): 1903 - 1914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bauters, P. V. Ennezat, O. Tricot, B. Lauwerier, R. Lallemant, H. Saadouni, P. Quandalle, O. Jaboureck, N. Lamblin, T. Le Tourneau, et al. Stress hyperglycaemia is an independent predictor of left ventricular remodelling after first anterior myocardial infarction in non-diabetic patients Eur. Heart J., March 1, 2007; 28(5): 546 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G A Whalley, G D Gamble, and R N Doughty Restrictive diastolic filling predicts death after acute myocardial infarction: systematic review and meta-analysis of prospective studies Heart, November 1, 2006; 92(11): 1588 - 1594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Moller, P. A. Pellikka, G. S. Hillis, and J. K. Oh Prognostic Importance of Diastolic Function and Filling Pressure in Patients With Acute Myocardial Infarction Circulation, August 1, 2006; 114(5): 438 - 444. [Full Text] [PDF]
|
|
|
|
|
|
J. K. Oh Echocardiography as a Noninvasive Swan-Ganz Catheter Circulation, June 21, 2005; 111(24): 3192 - 3194. [Full Text] [PDF]
|
|
|
|
|
|
B A Popescu, F Antonini-Canterin, P L Temporelli, P Giannuzzi, E Bosimini, F Gentile, A P Maggioni, L Tavazzi, R Piazza, L Ascione, et al. Right ventricular functional recovery after acute myocardial infarction: relation with left ventricular function and interventricular septum motion. GISSI-3 echo substudy Heart, April 1, 2005; 91(4): 484 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Weyman The year in echocardiography J. Am. Coll. Cardiol., February 1, 2005; 45(3): 448 - 455. [Full Text] [PDF]
|
|
|
|
|
|
M. Wang, G. Yip, C.-M. Yu, Q. Zhang, Y. Zhang, D. Tse, S.-L. Kong, and J. E. Sanderson Independent and incremental prognostic value of early mitral annulus velocity in patients with impaired left ventricular systolic function J. Am. Coll. Cardiol., January 18, 2005; 45(2): 272 - 277. [Abstract] [Full Text] [PDF]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
