|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 2004; 43:1388-1395, doi:10.1016/j.jacc.2003.10.061 © 2004 by the American College of Cardiology Foundation |
,*
* Laboratory of Cardiovascular Science, Laboratory of Clinical Investigation, Gerontology Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
U.O. Geriatria, INRCA, Rome, Italy
Manuscript received July 3, 2003; revised manuscript received September 6, 2003, accepted October 20, 2003.
* Reprint requests and correspondence: Dr. Angelo Scuteri, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland 21224-6825, USA.
Scuteria{at}grc.nia.nih.gov
OBJECTIVES: We sought to evaluate whether the clustering of multiple components of the metabolic syndrome (MS) has a greater impact on these vascular parameters than individual components of MS.
BACKGROUND: Intima-media thickness (IMT) and vascular stiffness have been shown to be independent predictors of adverse cardiovascular events. The MS is defined as the clustering of three or more of the cardiovascular risk factors of dysglycemia, hypertension, dyslipidemia, and obesity.
METHODS: Carotid IMT and stiffness were derived via B-mode ultrasonography in 471 participants from the Baltimore Longitudinal Study on Aging, who were without clinical cardiovascular disease and not receiving antihypertensive therapy.
RESULTS: The MS conferred a disproportionate increase in carotid IMT (+16%, p < 0.0001) and stiffness (+32%, p < 0.0001), compared with control subjects. Multiple regression models, which included age, gender, smoking, low-density lipoprotein, as well as each individual component of MS as continuous variables, showed that MS was an independent determinant of both IMT (p = 0.002) and stiffness (p = 0.012). The MS was associated with a greater prevalence of subjects whose values were in the highest quartiles of IMT, stiffness, or both.
CONCLUSIONS: Even after taking into account each individual component of MS, the clustering of at least three of these components is independently associated with increased IMT and stiffness. This suggests that the components of MS interact to synergistically impact vascular thickness and stiffness. Future studies should examine whether the excess cardiovascular risk associated with MS is partly mediated through the amplified alterations in these vascular properties.
| ||||||||||||||||||||||
This article has been cited by other articles:
|
|
 |
|
  N. Mattsson, T. Ronnemaa, M. Juonala, J. S.A. Viikari, E. Jokinen, N. Hutri-Kahonen, M. Kahonen, T. Laitinen, and O. T. Raitakari Arterial structure and function in young adults with the metabolic syndrome: the Cardiovascular Risk in Young Finns Study Eur. Heart J., March 2, 2008; 29(6): 784 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Ghiadoni, G. Penno, C. Giannarelli, Y. Plantinga, M. Bernardini, L. Pucci, R. Miccoli, S. Taddei, A. Salvetti, and S. Del Prato Metabolic Syndrome and Vascular Alterations in Normotensive Subjects at Risk of Diabetes Mellitus Hypertension, February 1, 2008; 51(2): 440 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. Godia, R. Madhok, J. Pittman, S. Trocio, R. Ramas, D. Cabral, R. L. Sacco, and T. Rundek Carotid Artery Distensibility: A Reliability Study J. Ultrasound Med., September 1, 2007; 26(9): 1157 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. F. Mitchell, C.-Y. Guo, E. J. Benjamin, M. G. Larson, M. J. Keyes, J. A. Vita, R. S. Vasan, and D. Levy Cross-Sectional Correlates of Increased Aortic Stiffness in the Community: The Framingham Heart Study Circulation, May 22, 2007; 115(20): 2628 - 2636. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Empana, M. Zureik, J. Gariepy, D. Courbon, J. F. Dartigues, K. Ritchie, C. Tzourio, A. Alperovitch, and P. Ducimetiere The Metabolic Syndrome and the Carotid Artery Structure in Noninstitutionalized Elderly Subjects: The Three-City Study Stroke, March 1, 2007; 38(3): 893 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Johnsen, S. E. Dolan, K. V. Fitch, J. R. Kanter, L. C. Hemphill, J. M. Connelly, R. S. Lees, H. Lee, and S. Grinspoon Carotid Intimal Medial Thickness in Human Immunodeficiency Virus-Infected Women: Effects of Protease Inhibitor Use, Cardiac Risk Factors, and the Metabolic Syndrome J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 4916 - 4924. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Huebschmann, J. G. Regensteiner, H. Vlassara, and J. E.B. Reusch Diabetes and Advanced Glycoxidation End Products. Diabetes Care, June 1, 2006; 29(6): 1420 - 1432. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ratto, G. Leoncini, F. Viazzi, V. Vaccaro, A. Parodi, V. Falqui, N. Conti, C. Tomolillo, G. Deferrari, and R. Pontremoli Metabolic Syndrome and Cardiovascular Risk in Primary Hypertension. J. Am. Soc. Nephrol., April 1, 2006; 17(4_suppl_2): S120 - S122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hassinen, P. Komulainen, T. A. Lakka, S. B. Vaisanen, I. Haapala, H. Gylling, M. Alen, A. Schmidt-Trucksass, A. Nissinen, and R. Rauramaa Metabolic syndrome and the progression of carotid intima-media thickness in elderly women. Arch Intern Med, February 27, 2006; 166(4): 444 - 449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Najjar, A. Scuteri, and E. G. Lakatta Arterial Aging: Is It an Immutable Cardiovascular Risk Factor? Hypertension, September 1, 2005; 46(3): 454 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Frisbee Reduced nitric oxide bioavailability contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R307 - R316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Bushnell and D. Guzick Metabolic syndrome and intracranial atherosclerosis: A new link? Neurology, July 26, 2005; 65(2): 188 - 189. [Full Text] [PDF]
|
|
|
|
|
|
G. Schillaci, M. Pirro, G. Vaudo, M. R. Mannarino, G. Savarese, G. Pucci, S. S. Franklin, and E. Mannarino Metabolic Syndrome Is Associated With Aortic Stiffness in Untreated Essential Hypertension Hypertension, June 1, 2005; 45(6): 1078 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Sengstock, P. V. Vaitkevicius, and M. A. Supiano Arterial Stiffness Is Related to Insulin Resistance in Nondiabetic Hypertensive Older Adults J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2823 - 2827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Zieman, V. Melenovsky, and D. A. Kass Mechanisms, Pathophysiology, and Therapy of Arterial Stiffness Arterioscler. Thromb. Vasc. Biol., May 1, 2005; 25(5): 932 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Ferreira, R. M. A. Henry, J. W. R. Twisk, W. van Mechelen, H. C. G. Kemper, and C. D. A. Stehouwer The Metabolic Syndrome, Cardiopulmonary Fitness, and Subcutaneous Trunk Fat as Independent Determinants of Arterial Stiffness: The Amsterdam Growth and Health Longitudinal Study Arch Intern Med, April 25, 2005; 165(8): 875 - 882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Scuteri, S. S. Najjar, C. H. Morrell, and E. G. Lakatta The Metabolic Syndrome in Older Individuals: Prevalence and Prediction of Cardiovascular Events: The Cardiovascular Health Study Diabetes Care, April 1, 2005; 28(4): 882 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Irace, C. Cortese, E. Fiaschi, C. Carallo, G. Sesti, E. Farinaro, and A. Gnasso Components of the Metabolic Syndrome and Carotid Atherosclerosis: Role of Elevated Blood Pressure Hypertension, April 1, 2005; 45(4): 597 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. DeMaria, O. Ben-Yehuda, D. Berman, G. K. Feld, B. H. Greenberg, J. D. Knoke, K. U. Knowlton, W. Y.W. Lew, J. Narula, D. Sahn, et al. Highlights of the year in JACC 2004 J. Am. Coll. Cardiol., January 4, 2005; 45(1): 137 - 153. [Full Text] [PDF]
|
|
|
|
|
|
S.-H. H. Juo, H.-F. Lin, T. Rundek, E. A. Sabala, B. Boden-Albala, N. Park, M.-Y. Lan, and R. L. Sacco Genetic and Environmental Contributions to Carotid Intima-Media Thickness and Obesity Phenotypes in the Northern Manhattan Family Study Stroke, October 1, 2004; 35(10): 2243 - 2247. [Abstract] [Full Text] [PDF]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
