JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
QUICK SEARCH:   [advanced]


     

J Am Coll Cardiol, 2004; 43:1195-1200, doi:10.1016/j.jacc.2003.10.049
© 2004 by the American College of Cardiology Foundation
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ohashi, K.
Right arrow Articles by Matsuzawa, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ohashi, K.
Right arrow Articles by Matsuzawa, Y.

CLINICAL RESEARCH: ATHEROSCLEROSIS

Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease

Koji Ohashi, MD*, Noriyuki Ouchi, MD, PhD*, Shinji Kihara, MD, PhD*,*, Tohru Funahashi, MD, PhD*, Tadashi Nakamura, MD, PhD*, Satoru Sumitsuji, MD{ddagger}, Toshiharu Kawamoto, MD, PhD§, Satoru Matsumoto, MD||, Hiroyuki Nagaretani, MD*, Masahiro Kumada, MD*, Yoshihisa Okamoto, MD*, Hitoshi Nishizawa, MD, PhD*, Ken Kishida, MD, PhD*, Norikazu Maeda, MD*, Hisatoyo Hiraoka, MD, PhD*, Yoshio Iwashima, MD{dagger}, Kazuhiko Ishikawa, MD, PhD{dagger}, Mitsuru Ohishi, MD, PhD{dagger}, Tomohiro Katsuya, MD, PhD{dagger}, Hiromi Rakugi, MD, PhD{dagger}, Toshio Ogihara, MD, PhD{dagger} and Yuji Matsuzawa, MD, PhD*

* Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
{dagger} Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Izumisano, Japan
{ddagger} Department of Cardiology, Rinku General Medical Center, Rinku, Japan
§ Department of Cardiology, National Hospital Kure Medical Center, Kure, Japan
|| Department of Cardiology, Toyonaka Municipal Hospital, Toyonaka, Japan

Manuscript received April 21, 2003; revised manuscript received September 12, 2003, accepted October 20, 2003.

* Reprints requests and correspondence: Dr. Shinji Kihara, Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.
kihara{at}imed2.med.osaka-u.ac.jp

OBJECTIVES: This study examined the association of mutations in adiponectin gene with the prevalence of coronary artery disease (CAD).

BACKGROUND: Coronary artery disease is a major cause of mortality in the industrial countries. Adiponectin gene locus, chromosome 3q27, is the candidate site for CAD. We have reported that adiponectin has antiatherogenic and antidiabetic properties, and that the plasma levels negatively correlated with body mass index (BMI) are significantly low in patients with CAD or type 2 diabetes.

METHODS: The study subjects were 383 consecutive patients with angiographically confirmed CAD and 368 non-CAD subjects adjusted for age and BMI in the Japanese population. Single nucleotide polymorphisms (SNPs) in the adiponectin gene were determined by Taqman polymerase chain reaction (PCR) method or a PCR-based assay for the analysis of restriction fragment length polymorphism. The plasma adiponectin concentration was measured by enzyme-linked immunosorbent assay.

RESULTS: Among SNPs, the frequency of I164T mutation was significantly higher in CAD subjects (2.9%) than in the control (0.8%, p < 0.05). The plasma adiponectin levels in subjects carrying the I164T mutation were significantly lower than in those without the mutation, and were independent of BMI. In contrast, SNP94 and SNP276, which are reported to be associated with an increased risk of type 2 diabetes, were associated neither with CAD prevalence nor with plasma adiponectin level. Subjects with I164T mutation exhibited a clinical phenotype of the metabolic syndrome.

CONCLUSIONS: The I164T mutation in the adiponectin gene was a common genetic background associated with the metabolic syndrome and CAD in the Japanese population.

Abbreviations and Acronyms
  BMI = body mass index
  CAD = coronary artery disease
  HbA1C = hemoglobin A1C
  HDL-chol = high-density lipoprotein cholesterol
  HOMA = homeostasis model assessment
  PCR = polymerase chain reaction
  SNP = single nucleotide polymorphism
  T-chol = total cholesterol
  TG = triglyceride
  TNF = tumor necrosis factor




This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
A. T. Gonon, U. Widegren, A. Bulhak, F. Salehzadeh, J. Persson, P.-O. Sjoquist, and J. Pernow
Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide
Cardiovasc Res, April 1, 2008; 78(1): 116 - 122.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
R. Schnabel, C. M. Messow, E. Lubos, C. Espinola-Klein, H. J. Rupprecht, C. Bickel, C. Sinning, S. Tzikas, T. Keller, S. Genth-Zotz, et al.
Association of adiponectin with adverse outcome in coronary artery disease patients: results from the AtheroGene study
Eur. Heart J., March 1, 2008; 29(5): 649 - 657.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. Femia, M. Kozakova, M. Nannipieri, C. Gonzales-Villalpando, M. P. Stern, S. M. Haffner, and E. Ferrannini
Carotid Intima-Media Thickness in Confirmed Prehypertensive Subjects: Predictors and Progression
Arterioscler. Thromb. Vasc. Biol., October 1, 2007; 27(10): 2244 - 2249.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Public HealthHome page
L. Ho, V. Bos, and A. E. Kunst
Differences in Cause-of-Death Patterns Between the Native Dutch and Persons of Indonesian Descent in the Netherlands
Am J Public Health, September 1, 2007; 97(9): 1616 - 1618.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Cesari, K. Narkiewicz, R. De Toni, E. Aldighieri, C. J. Williams, and G. P. Rossi
Heritability of Plasma Adiponectin Levels and Body Mass Index in Twins
J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3082 - 3088.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H. Katagiri, T. Yamada, and Y. Oka
Adiposity and Cardiovascular Disorders: Disturbance of the Regulatory System Consisting of Humoral and Neuronal Signals
Circ. Res., July 6, 2007; 101(1): 27 - 39.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. Menzaghi, V. Trischitta, and A. Doria
Genetic Influences of Adiponectin on Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease
Diabetes, May 1, 2007; 56(5): 1198 - 1209.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. E. Szmitko, H. Teoh, D. J. Stewart, and S. Verma
Adiponectin and cardiovascular disease: state of the art?
Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1655 - H1663.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. Bajaj and O. Ben-Yehuda
A Big Fat Wedding: Association of Adiponectin With Coronary Vascular Lesions
J. Am. Coll. Cardiol., September 19, 2006; 48(6): 1163 - 1165.
[Full Text] [PDF]

Home page
 DiabetesHome page
X. Guo, M. F. Saad, C. D. Langefeld, A. H. Williams, J. Cui, K. D. Taylor, J. M. Norris, S. Jinagouda, C. H. Darwin, B. D. Mitchell, et al.
Genome-Wide Linkage of Plasma Adiponectin Reveals a Major Locus on Chromosome 3q Distinct From the Adiponectin Structural Gene: The IRAS Family Study
Diabetes, June 1, 2006; 55(6): 1723 - 1730.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
K. Ohashi, S. Kihara, N. Ouchi, M. Kumada, K. Fujita, A. Hiuge, T. Hibuse, M. Ryo, H. Nishizawa, N. Maeda, et al.
Adiponectin Replenishment Ameliorates Obesity-Related Hypertension
Hypertension, June 1, 2006; 47(6): 1108 - 1116.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
I. M. Heid, S. A. Wagner, H. Gohlke, B. Iglseder, J. C. Mueller, P. Cip, G. Ladurner, R. Reiter, A. Stadlmayr, V. Mackevics, et al.
Genetic Architecture of the APM1 Gene and Its Influence on Adiponectin Plasma Levels and Parameters of the Metabolic Syndrome in 1,727 Healthy Caucasians
Diabetes, February 1, 2006; 55(2): 375 - 384.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
S. P. Efstathiou, D. I. Tsioulos, A. G. Tsiakou, Y. E. Gratsias, A. V. Pefanis, and T. D. Mountokalakis
Plasma Adiponectin Levels and Five-Year Survival After First-Ever Ischemic Stroke
Stroke, September 1, 2005; 36(9): 1915 - 1919.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. O. Goodarzi, K. D. Taylor, X. Guo, M. J. Quinones, J. Cui, Y. Li, M. F. Saad, H. Yang, W. A. Hsueh, H. N. Hodis, et al.
Association of the Diabetes Gene Calpain-10 With Subclinical Atherosclerosis: The Mexican-American Coronary Artery Disease Study
Diabetes, April 1, 2005; 54(4): 1228 - 1232.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
D. C. Chan, G. F. Watts, T. W.K. Ng, Y. Uchida, N. Sakai, S. Yamashita, and P. H. R. Barrett
Adiponectin and other Adipocytokines as Predictors of Markers of Triglyceride-Rich Lipoprotein Metabolism
Clin. Chem., March 1, 2005; 51(3): 578 - 585.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. N. DeMaria, O. Ben-Yehuda, D. Berman, G. K. Feld, B. H. Greenberg, J. D. Knoke, K. U. Knowlton, W. Y.W. Lew, J. Narula, D. Sahn, et al.
Highlights of the year in JACC 2004
J. Am. Coll. Cardiol., January 4, 2005; 45(1): 137 - 153.
[Full Text] [PDF]


HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
Copyright © 2004 by the American College of Cardiology Foundation.