CLINICAL RESEARCH: INTERVENTIONAL CARDIOLOGY
A randomized trial comparing myocardial salvage achieved by coronary stenting versus balloon angioplasty in patients with acute myocardial infarction considered ineligible for reperfusion therapy
Adnan Kastrati, MD*,*,
Julinda Mehilli, MD*,
Stefan Nekolla, PhD ,
Hildegard Bollwein, MD ,
Stefan Martinoff, MD*,
Jürgen Pache, MD,
Helmut Schühlen, MD*,
Melchior Seyfarth, MD,
Meinrad Gawaz, MD*,
Franz-Josef Neumann, MD,
Josef Dirschinger, MD,
Markus Schwaiger, MD,
Albert Schömig, MD* STOPAMI-3 Study Investigators
* Deutsches Herzzentrum, Munich, Germany
1. Medizinische Klinik rechts der Isar, Munich, Germany
Klinik und Poliklinik für Nuklearmedizin rechts der Isar, Technische Universität, Munich, Germany
Manuscript received May 14, 2003;
revised manuscript received July 24, 2003,
accepted July 29, 2003.
* Reprint requests and correspondence: Dr. Adnan Kastrati, Deutsches Herzzentrum Lazarettstr. 36, 80636 München, Germany
kastrati{at}dhm.mhn.de
OBJECTIVES: We assessed myocardial salvage achieved by reperfusion with percutaneous coronary interventions (PCI) and compared stenting with balloon angioplasty (PTCA) in patients with acute myocardial infarction (AMI) ineligible for thrombolysis.
BACKGROUND: A substantial proportion of patients with AMI are currently considered ineligible for thrombolysis, and reperfusion treatment is frequently not recommended for them. It is not known whether these patients benefit from PCI.
METHODS: The Stent or PTCA for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction Ineligible for Thrombolysis (STOPAMI-3) trial, a randomized, open-label study, included 611 patients with AMI who were ineligible for thrombolysis (lack of ST-segment elevation on the electrocardiogram, late presentation >12 h after symptom onset, and contraindications to thrombolysis). Patients were randomly assigned to receive either coronary artery stenting (n = 305) or PTCA (n = 306). Scintigraphic myocardial salvage index (proportion of the initial myocardial perfusion defect that was salvaged by reperfusion) was the primary end point of the study.
RESULTS: A considerable myocardial salvage was achieved with both stenting and PTCA. In patients assigned to receive stenting, the median size of the salvage index was 0.54 (25th and 75th percentiles, 0.29 and 0.87), as compared with a median of 0.50 (25th and 75th percentiles, 0.26 and 0.82) in the group assigned to receive PTCA (p = 0.20). Mortality at six months was 8.2% in the group of patients assigned to receive stenting and 9.2% in the group of patients assigned to receive PTCA (p = 0.69).
CONCLUSIONS: Patients with AMI who are currently considered ineligible for thrombolysis by conventional guidelines may greatly benefit from primary PCI. The benefit seems to be comparable when a strategy of stenting is compared with a strategy of PTCA in these patients.
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Abbreviations and Acronyms
| | AMI | = acute myocardial infarction | | CK | = creatine kinase | | ECG | = electrocardiogram | | LV | = left ventricle/ventricular | | MI | = myocardial infarction | | PTCA | = percutaneous transluminal coronary angioplasty | | STOPAMI-3 | = Stent or PTCA for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction Ineligible for Thrombolysis study |
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