STATE-OF-THE-ART PAPER
Heart failure with preserved left ventricular systolic function
epidemiology, clinical characteristics, and prognosis
Karen Hogg, BSC, MBChB, MRCP*,
Karl Swedberg, MD, PhD and
John McMurray, MD, FRCP, FESC, FACC*,*
* Department of Cardiology, Western Infirmary, Glasgow, Scotland, United Kingdom
Department of Medicine, Sahlgrenska University Hospital/Ostra, Göteborg, Sweden
Manuscript received April 1, 2003;
revised manuscript received June 26, 2003,
accepted July 21, 2003.
* Reprint requests and correspondence: Prof. John J. V. McMurray, Department of Cardiology, Western Infirmary, Glasgow, G12 8QQ, United Kingdom.
j.mcmurray{at}bio.gla.ac.uk
Recent cross-sectional, population-based echocardiographic studies show that about half of all patients with heart failure have preserved left ventricular systolic function (HF-PSF). Cohort studies of hospitalized patients show a smaller proportion of HF-PSF. Compared to those with reduced systolic function, patients with HF-PSF are more often female, older, less likely to have coronary artery disease, and more likely to have hypertension. Patients with HF-PSF are less symptomatic and receive different pharmacologic therapy than patients with reduced systolic function. Morbidity and mortality rates in patients with HF-PSF are high but not quite as high as in patients with reduced systolic function. Though much has recently been learned about the syndrome of HF-PSF, many questions remain to be answered, not least how it should be treated.
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Abbreviations and Acronyms
| | AF | = atrial fibrillation | | CHF | = chronic heart failure | | CHD | = coronary heart disease | | DD | = diastolic dysfunction | | ECG | = electrocardiogram/electrocardiographic | | FS | = fractional shortening | | IVRT | = isovolumic relaxation time | | LV | = left ventricle/ventricular | | LVEF | = left ventricular ejection fraction | | PSF | = preserved systolic function |
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