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J Am Coll Cardiol, 2004; 43:317-327, doi:10.1016/j.jacc.2003.07.046
© 2004 by the American College of Cardiology Foundation
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STATE-OF-THE-ART PAPER

Heart failure with preserved left ventricular systolic function

epidemiology, clinical characteristics, and prognosis

Karen Hogg, BSC, MBChB, MRCP*, Karl Swedberg, MD, PhD{dagger} and John McMurray, MD, FRCP, FESC, FACC*,*

* Department of Cardiology, Western Infirmary, Glasgow, Scotland, United Kingdom
{dagger} Department of Medicine, Sahlgrenska University Hospital/Ostra, Göteborg, Sweden

Manuscript received April 1, 2003; revised manuscript received June 26, 2003, accepted July 21, 2003.

* Reprint requests and correspondence: Prof. John J. V. McMurray, Department of Cardiology, Western Infirmary, Glasgow, G12 8QQ, United Kingdom.
j.mcmurray{at}bio.gla.ac.uk

Recent cross-sectional, population-based echocardiographic studies show that about half of all patients with heart failure have preserved left ventricular systolic function (HF-PSF). Cohort studies of hospitalized patients show a smaller proportion of HF-PSF. Compared to those with reduced systolic function, patients with HF-PSF are more often female, older, less likely to have coronary artery disease, and more likely to have hypertension. Patients with HF-PSF are less symptomatic and receive different pharmacologic therapy than patients with reduced systolic function. Morbidity and mortality rates in patients with HF-PSF are high but not quite as high as in patients with reduced systolic function. Though much has recently been learned about the syndrome of HF-PSF, many questions remain to be answered, not least how it should be treated.

Abbreviations and Acronyms
  AF = atrial fibrillation
  CHF = chronic heart failure
  CHD = coronary heart disease
  DD = diastolic dysfunction
  ECG = electrocardiogram/electrocardiographic
  FS = fractional shortening
  IVRT = isovolumic relaxation time
  LV = left ventricle/ventricular
  LVEF = left ventricular ejection fraction
  PSF = preserved systolic function




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Eur Heart JHome page
F. H. Rutten, M.-J. M. Cramer, D. E. Grobbee, A. P.E. Sachs, J. H. Kirkels, J.-W. J. Lammers, and A. W. Hoes
Unrecognized heart failure in elderly patients with stable chronic obstructive pulmonary disease
Eur. Heart J., September 2, 2005; 26(18): 1887 - 1894.
[Abstract] [Full Text] [PDF]


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CirculationHome page
M. A. Arias, F. Garcia-Rio, A. Alonso-Fernandez, O. Mediano, I. Martinez, and J. Villamor
Obstructive Sleep Apnea Syndrome Affects Left Ventricular Diastolic Function: Effects of Nasal Continuous Positive Airway Pressure in Men
Circulation, July 19, 2005; 112(3): 375 - 383.
[Abstract] [Full Text] [PDF]


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Eur Heart JHome page
Authors/Task Force Members, K. Swedberg, Writing Committee:, J. Cleland, H. Dargie, H. Drexler, F. Follath, M. Komajda, L. Tavazzi, O. A. Smiseth, et al.
Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology
Eur. Heart J., June 1, 2005; 26(11): 1115 - 1140.
[Full Text] [PDF]


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HeartHome page
A Varela-Roman, L Grigorian, E Barge, P Bassante, M G de la Pena, and J R Gonzalez-Juanatey
Heart failure in patients with preserved and deteriorated left ventricular ejection fraction
Heart, April 1, 2005; 91(4): 489 - 494.
[Abstract] [Full Text] [PDF]


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Eur Heart JHome page
J. McMurray
Making sense of SENIORS
Eur. Heart J., February 1, 2005; 26(3): 203 - 206.
[Full Text] [PDF]


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J. Appl. Physiol.Home page
A. V. Finsen, G. Christensen, and I. Sjaastad
Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse
J Appl Physiol, February 1, 2005; 98(2): 680 - 689.
[Abstract] [Full Text] [PDF]


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Eur Heart JHome page
K. Dickstein
Appearances can deceive: even brave hearts can fail
Eur. Heart J., July 2, 2004; 25(14): 1181 - 1182.
[Full Text] [PDF]


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NEJMHome page
M. Martinez-Selles, C. Mueller, and A. P. Perruchoud
B-Type Natriuretic Peptide in the Evaluation of Acute Dyspnea
N. Engl. J. Med., June 3, 2004; 350(23): 2416 - 2417.
[Full Text] [PDF]


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Journal of Renin-Angiotensin-Aldosterone SystemHome page
M. Tendera
The epidemiology of heart failure
Journal of Renin-Angiotensin-Aldosterone System, March 1, 2004; 5(1_suppl): S2 - S6.
[Abstract] [PDF]



 
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