Advertisement






Click here for more guidelines.
CME Topic Collections Past Issues Search Current Issue Home
     

J Am Coll Cardiol, 2004; 43:179-184, doi:10.1016/j.jacc.2003.07.042
© 2004 by the American College of Cardiology Foundation
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kaiser, D. R.
Right arrow Articles by Bank, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaiser, D. R.
Right arrow Articles by Bank, A. J.

CLINICAL RESEARCH: NON-CARDIAC FINDINGS AND CORONARY ATHEROSCLEROSIS

Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease

Daniel R. Kaiser, PhD*, Kevin Billups, MD{dagger}, Carol Mason, NP*, Rebecca Wetterling, BS*, Jennifer L. Lundberg, MS* and Alan J. Bank, MD, FACC*,*

* St. Paul Heart Clinic, St. Paul, USA
{dagger} EpiCenter for Sexual Health and Medicine, St. Paul, Minnesota, USA

Manuscript received May 5, 2003; revised manuscript received July 2, 2003, accepted July 14, 2003.

* Reprint requests and correspondence: Dr. Alan J. Bank, Associate Professor, University of Minnesota, Director of Research, St. Paul Heart Clinic, 255 N. Smith Avenue, Suite 100, St. Paul, Minnesota 55102, USA.
abank{at}stphc.com

OBJECTIVES: The goal of this study was to determine whether patients with vascular erectile dysfunction (ED) and no other clinical cardiovascular disease have structural and functional abnormalities of other vascular beds.

BACKGROUND: In many ED patients, vascular disease is the major underlying cause. It may be that ED is an early marker of atherosclerosis in patients without clinical cardiovascular disease.

METHODS: We assessed systemic vascular structure and function in 30 patients with ED and 27 age-matched normal control (NL) subjects. We measured vascular parameters, including: 1) carotid and brachial artery diameters, intima-media thickness, compliance, and distensibility; 2) aortic pulse wave velocity; 3) coronary calcification; and 4) brachial artery endothelium-dependent and -independent vasodilation.

RESULTS: There were no significant differences in baseline demographics, coronary artery risk score, or lipid values between the two groups. Most structural and functional vascular parameters were similar in the ED and NL groups. Brachial artery flow-mediated vasodilation (FMD) (1.3 vs. 2.4%, p = 0.014) and vasodilation to nitroglycerin (NTG) (13.0 vs. 17.8%, p < 0.05) were significantly reduced in ED patients, compared with NL subjects. In addition, there was a significant correlation between FMD and vasodilation to NTG in ED patients (r = 0.59, p < 0.05) but not in NL subjects.

CONCLUSIONS: Patients with ED but no clinical cardiovascular disease have a peripheral vascular defect in endothelium-dependent and -independent vasodilation that occurs before the development of other overt functional or structural systemic vascular disease and is independent of other traditional cardiovascular risk factors.

Abbreviations and Acronyms
  CAD = coronary artery disease
  ED = erectile dysfunction
  EDV = end-diastolic velocity
  FMD = flow-mediated vasodilation
  HDL = high-density lipoprotein
  IIEF-15 = 15-item International Index of Erectile Function
  IMT = intima-media thickness
  LDL = low-density lipoprotein
  NL = normal control subjects
  NO-cGMP = nitric oxide–cyclic guanosine-3'5'-monophosphate
  NTG = nitroglycerin
  PGE1 = prostaglandin E1
  PSV = peak systolic velocity
  PWV = pulse wave velocity
  RI = resistance index




This article has been cited by other articles:


Home page
Therapeutic Advances in UrologyHome page
A. Aversa, R. Bruzziches, D. Francomano, M. Natali, and A. Lenzi
Testosterone and phosphodiesterase type-5 inhibitors: new strategy for preventing endothelial damage in internal and sexual medicine?
Therapeutic Advances in Urology, October 1, 2009; 1(4): 179 - 197.
[Abstract] [PDF]


Home page
Cardiovasc ResHome page
T. Reffelmann and R. A. Kloner
Phosphodiesterase 5 inhibitors: are they cardioprotective?
Cardiovasc Res, July 15, 2009; 83(2): 204 - 212.
[Abstract] [Full Text] [PDF]


Home page
Mayo Clin Proc.Home page
A. Nehra
Erectile Dysfunction and Cardiovascular Disease: Efficacy and Safety of Phosphodiesterase Type 5 Inhibitors in Men With Both Conditions
Mayo Clin. Proc., February 1, 2009; 84(2): 139 - 148.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
R. C.-W. Ma, W.-Y. So, X. Yang, L. W.-L. Yu, A. P.-S. Kong, G. T.-C. Ko, C.-C. Chow, C. S. Cockram, J. C.-N. Chan, and P. C.-Y. Tong
Erectile Dysfunction Predicts Coronary Heart Disease in Type 2 Diabetes
J. Am. Coll. Cardiol., May 27, 2008; 51(21): 2045 - 2050.
[Abstract] [Full Text] [PDF]


Home page
Vasc MedHome page
A. S. Kelly, A. M. Thelen, D. R. Kaiser, J. M. Gonzalez-Campoy, and A. J. Bank
Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus
Vascular Medicine, November 1, 2007; 12(4): 311 - 318.
[Abstract] [PDF]


Home page
AMERICAN JOURNAL OF LIFESTYLE MEDICINEHome page
M. Miner
Engaging Patients in Cardiovascular Disease Risk Reduction: From Empathy to Erectile Dysfunction
American Journal of Lifestyle Medicine, January 1, 2007; 1(1): 41 - 43.
[Abstract] [PDF]


Home page
Eur Heart JHome page
C. Vlachopoulos, K. Aznaouridis, N. Ioakeimidis, K. Rokkas, C. Vasiliadou, N. Alexopoulos, E. Stefanadi, A. Askitis, and C. Stefanadis
Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease
Eur. Heart J., November 2, 2006; 27(22): 2640 - 2648.
[Abstract] [Full Text] [PDF]


Home page
Vasc MedHome page
A. J Bank, A. S Kelly, D. R Kaiser, W. W Crawford, B. Waxman, D. A Schow, and K. L Billups
The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
Vascular Medicine, November 1, 2006; 11(4): 251 - 257.
[Abstract] [PDF]


Home page
J Am Coll CardiolHome page
E. R. Schwarz, S. Rastogi, V. Kapur, N. Sulemanjee, and J. J. Rodriguez
Erectile Dysfunction in Heart Failure Patients
J. Am. Coll. Cardiol., September 19, 2006; 48(6): 1111 - 1119.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
A. A. Elesber, H. Solomon, R. J. Lennon, V. Mathew, A. Prasad, G. Pumper, R. E. Nelson, J. P. McConnell, L. O. Lerman, and A. Lerman
Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis
Eur. Heart J., April 1, 2006; 27(7): 824 - 831.
[Abstract] [Full Text] [PDF]


Home page
Arch Intern MedHome page
J. K. Min, K. A. Williams, T. M. Okwuosa, G. W. Bell, M. S. Panutich, and R. P. Ward
Prediction of Coronary Heart Disease by Erectile Dysfunction in Men Referred for Nuclear Stress Testing
Arch Intern Med, January 23, 2006; 166(2): 201 - 206.
[Abstract] [Full Text] [PDF]


Home page
Arch Intern MedHome page
S. A. Grover, I. Lowensteyn, M. Kaouache, S. Marchand, L. Coupal, E. DeCarolis, J. Zoccoli, and I. Defoy
The Prevalence of Erectile Dysfunction in the Primary Care Setting: Importance of Risk Factors for Diabetes and Vascular Disease
Arch Intern Med, January 23, 2006; 166(2): 213 - 219.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
E. Chiurlia, R. D'Amico, C. Ratti, A. R. Granata, R. Romagnoli, and M. G. Modena
Subclinical Coronary Artery Atherosclerosis in Patients With Erectile Dysfunction
J. Am. Coll. Cardiol., October 18, 2005; 46(8): 1503 - 1506.
[Abstract] [Full Text] [PDF]


Home page
Diabetes CareHome page
K. Esposito, F. Giugliano, E. Martedi, G. Feola, R. Marfella, M. D'Armiento, and D. Giugliano
High Proportions of Erectile Dysfunction in Men With the Metabolic Syndrome
Diabetes Care, May 1, 2005; 28(5): 1201 - 1203.
[Full Text] [PDF]


Home page
CirculationHome page
R. A. Kloner
Cardiovascular Effects of the 3 Phosphodiesterase-5 Inhibitors Approved for the Treatment of Erectile Dysfunction
Circulation, November 9, 2004; 110(19): 3149 - 3155.
[Full Text] [PDF]


Home page
J Am Coll CardiolHome page
P. Montorsi, A. Briganti, A. Salonia, A. Margonato, and F. Montorsi
Impaired vascular reactivity in patients with erectile dysfunction
J. Am. Coll. Cardiol., September 15, 2004; 44(6): 1339 - 1340.
[Full Text] [PDF]


Home page
J Am Coll CardiolHome page
D. R. Kaiser, K. Billups, C. Mason, R. Wetterling, J. L. Lundberg, and A. J. Bank
Reply
J. Am. Coll. Cardiol., September 15, 2004; 44(6): 1340 - 1341.
[Full Text] [PDF]


Home page
Journal Watch CardiologyHome page
Erectile Dysfunction: Risk Factor for Cardiovascular Disease?
Journal Watch Cardiology, March 12, 2004; 2004(312): 1 - 1.
[Full Text]



 
  CME Topic Collections Past Issues Search Current Issue Home

Advertisement