Diagnosis and differential assessment of pulmonary arterial hypertension
Robyn J. Barst, MD*,*,
Michael McGoon, MD ,
Adam Torbicki, MD ,
Olivier Sitbon, MD ,
Michael J. Krowka, MD,
Horst Olschewski, MD|| and
Sean Gaine, MD¶
* Columbia University College of Physicians and Surgeons, New York, New York, USA
Mayo Clinic, Rochester, Minnesota, USA
Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
Hôpital Antoine Béclère, Clamart, France
|| Medical Clinic II, University Clinic, Giessen, Germany
¶ Mater Misericordiae Hospital, University College, Dublin, Ireland
Manuscript received November 26, 2003;
accepted February 3, 2004.
*
Reprint requests and correspondence: Dr. Robyn J. Barst, Columbia University College of Physicians & Surgeons, 622 West 168 Street, PH 2 East, Suite 200, New York, New York 10032, USA.
rjb3{at}columbia.edu
Pulmonary arterial hypertension (PAH) is diagnosed by various investigations that are essential for making the diagnosis, and by additional tests to clarify the category of pulmonary hypertension (PH). A diagnostic algorithm can guide the evaluation of PH, but like all guidelines the algorithm can be modified according to specific clinical circumstances. Most patients are diagnosed as the result of an evaluation of symptoms, whereas others are diagnosed during screening of asymptomatic populations at risk. Right heart catheterization (RHC) must be performed in patients with suspected PH to establish the diagnosis and document pulmonary hemodynamics. Before initiation of medical therapy, assessment of acute vasoreactivity (during catheterization) is necessary to determine the appropriate therapy for an individual patient. An acute response is generally defined as a decrease in mean pulmonary arterial pressure of at least 10 mm Hg with the mean pulmonary arterial pressure decreasing to 40 mm Hg or below, accompanied by a normal or high cardiac output. After PAH is diagnosed, disease severity should be assessed in order to accurately determine risk:benefit profiles for various therapeutic options. Useful tools to predict outcome include functional class, exercise capacity, pulmonary hemodynamics, acute vasoreactivity, right ventricular function, as well as brain natriuretic peptide, endothelin-1, uric acid, and troponin levels. Repeating these tests serially on treatment is useful for monitoring the response to a given therapy. Close follow-up at a center specializing in management of PH is recommended, with careful periodic reassessment and adjustment of therapy.
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Abbreviations and Acronyms
| | BMI | = body mass index | | CI | = cardiac index | | CTEPH | = chronic thromboembolic pulmonary hypertension | | ECG | = electrocardiogram | | IPAH | = idiopathic pulmonary arterial hypertension | | PA | = pulmonary artery | | PAH | = pulmonary arterial hypertension | | PASP | = pulmonary artery systolic pressure | | PH | = pulmonary hypertension | | RAP | = right atrial pressure | | RHC | = right heart catheterization | | RVSP | = right ventricular systolic pressure | | TTE | = transthoracic Doppler echocardiography |  /
| = ventilation–perfusion |
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|
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|
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|
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|
|
|
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|
|
|
|
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|
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|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
K. E. Roberts, M. B. Fallon, M. J. Krowka, R. L. Benza, J. A. Knowles, D. B. Badesch, R. S. Brown Jr, D. B. Taichman, J. Trotter, S. Zacks, et al.
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135(6):
1470 - 1475.
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|
|
|
|
|
|
|
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179(7):
615 - 621.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
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84(4):
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|
|
|
|
|
|
|
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119(11):
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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High-altitude pulmonary hypertension
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March 1, 2009;
18(111):
13 - 17.
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[PDF]
|
|
|
|
|
|
|
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Evaluation of pulmonary artery stiffness in pulmonary hypertension with cardiac magnetic resonance.
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March 1, 2009;
2(3):
286 - 295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. P. Tan, N. N. Wynn, M. Umerov, A. Henderson, A. Gillham, S. Junejo, and S. K. Bansal
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February 1, 2009;
135(2):
448 - 454.
[Abstract]
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|
|
|
|
|
|
|
M. D. McGoon and G. C. Kane
Pulmonary Hypertension: Diagnosis and Management
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February 1, 2009;
84(2):
191 - 207.
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|
|
|
|
|
|
|
N. Skoro-Sajer, N. Hack, R. Sadushi-Kolici, D. Bonderman, J. Jakowitsch, W. Klepetko, M. A. R. Hoda, M. P. Kneussl, P. Fedullo, and I. M. Lang
Pulmonary Vascular Reactivity and Prognosis in Patients With Chronic Thromboembolic Pulmonary Hypertension: A Pilot Study
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119(2):
298 - 305.
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|
|
|
|
|
|
|
S Holverda, H Rietema, N Westerhof, J T Marcus, C T-J Gan, P E Postmus, and A Vonk-Noordegraaf
Stroke volume increase to exercise in chronic obstructive pulmonary disease is limited by increased pulmonary artery pressure
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January 15, 2009;
95(2):
137 - 141.
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|
|
|
|
|
|
|
I. R. Henkens, C. T.-J. Gan, S. A. van Wolferen, M. Hew, A. Boonstra, J. W. R. Twisk, O. Kamp, E. E. van der Wall, M. J. Schalij, A. Vonk Noordegraaf, et al.
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December 1, 2008;
134(6):
1250 - 1257.
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[PDF]
|
|
|
|
|
|
|
S. L Hrometz and K. M Shields
Role of Ambrisentan in the Management of Pulmonary Hypertension
Ann. Pharmacother.,
November 1, 2008;
42(11):
1653 - 1659.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
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Screening for PAH in patients with systemic sclerosis: focus on Doppler echocardiography
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October 1, 2008;
47(suppl_5):
v33 - v35.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
C P Denton, J E Pope, H-H Peter, A Gabrielli, A Boonstra, F H J van den Hoogen, G Riemekasten, S De Vita, A Morganti, M Dolberg, et al.
Long-term effects of bosentan on quality of life, survival, safety and tolerability in pulmonary arterial hypertension related to connective tissue diseases
Ann Rheum Dis,
September 1, 2008;
67(9):
1222 - 1228.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Warwick, P. S. Thomas, and D. H. Yates
Biomarkers in pulmonary hypertension
Eur. Respir. J.,
August 1, 2008;
32(2):
503 - 512.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Bourbonnais and L. Samavati
Clinical predictors of pulmonary hypertension in sarcoidosis
Eur. Respir. J.,
August 1, 2008;
32(2):
296 - 302.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Provencher, P. Herve, O. Sitbon, M. Humbert, G. Simonneau, and D. Chemla
Changes in exercise haemodynamics during treatment in pulmonary arterial hypertension
Eur. Respir. J.,
August 1, 2008;
32(2):
393 - 398.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Stolz, M. Christ-Crain, N. G. Morgenthaler, D. Miedinger, J. Leuppi, C. Muller, R. Bingisser, J. Struck, B. Muller, and M. Tamm
Plasma Pro-Adrenomedullin But Not Plasma Pro-Endothelin Predicts Survival in Exacerbations of COPD
Chest,
August 1, 2008;
134(2):
263 - 272.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Overbeek, J-W. Lankhaar, N. Westerhof, A. E. Voskuyl, A. Boonstra, J. G. F. Bronzwaer, K. M. J. Marques, E. F. Smit, B. A. C. Dijkmans, and A. Vonk-Noordegraaf
Right ventricular contractility in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension
Eur. Respir. J.,
June 1, 2008;
31(6):
1160 - 1166.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Terrier, M. C. Tamby, L. Camoin, P. Guilpain, C. Broussard, G. Bussone, A. Yaici, F. Hotellier, G. Simonneau, L. Guillevin, et al.
Identification of Target Antigens of Antifibroblast Antibodies in Pulmonary Arterial Hypertension
Am. J. Respir. Crit. Care Med.,
May 15, 2008;
177(10):
1128 - 1134.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. R. Henkens, K. T. B. Mouchaers, A. Vonk-Noordegraaf, A. Boonstra, C. A. Swenne, A. C. Maan, S.-C. Man, J. W. R. Twisk, E. E. van der Wall, M. J. Schalij, et al.
Improved ECG detection of presence and severity of right ventricular pressure load validated with cardiac magnetic resonance imaging
Am J Physiol Heart Circ Physiol,
May 1, 2008;
294(5):
H2150 - H2157.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Rietema, S. Holverda, H. J. Bogaard, J. T. Marcus, H. J. Smit, N. Westerhof, P. E. Postmus, A. Boonstra, and A. Vonk-Noordegraaf
Sildenafil treatment in COPD does not affect stroke volume or exercise capacity
Eur. Respir. J.,
April 1, 2008;
31(4):
759 - 764.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
National Pulmonary Hypertension Centres of the UK
Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland
Heart,
March 1, 2008;
94(Suppl_1):
i1 - i41.
[Full Text]
[PDF]
|
|
|
|
|
|
|
National Pulmonary Hypertension Centres of the UK
Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland
Thorax,
March 1, 2008;
63(Suppl_2):
ii1 - ii41.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Golbin, V. K. Somers, and S. M. Caples
Obstructive Sleep Apnea, Cardiovascular Disease, and Pulmonary Hypertension
Proceedings of the ATS,
February 15, 2008;
5(2):
200 - 206.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. Ivy, A. K. Doran, K. J. Smith, G. B. Mallory Jr, M. Beghetti, R. J. Barst, D. Brady, Y. Law, D. Parker, L. Claussen, et al.
Short- and Long-Term Effects of Inhaled Iloprost Therapy in Children With Pulmonary Arterial Hypertension
J. Am. Coll. Cardiol.,
January 15, 2008;
51(2):
161 - 169.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. D. Williams, B. M. Philip, L. F. Chu, M. G. Boltz, K. Kamra, H. Terwey, G. B. Hammer, S. B. Perry, J. A. Feinstein, and C. Ramamoorthy
Ketamine Does Not Increase Pulmonary Vascular Resistance in Children with Pulmonary Hypertension Undergoing Sevoflurane Anesthesia and Spontaneous Ventilation
Anesth. Analg.,
December 1, 2007;
105(6):
1578 - 1584.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Huez, F. Roufosse, J-L. Vachiery, A. Pavelescu, G. Derumeaux, J-C. Wautrecht, E. Cogan, and R. Naeije
Isolated right ventricular dysfunction in systemic sclerosis: latent pulmonary hypertension?
Eur. Respir. J.,
November 1, 2007;
30(5):
928 - 936.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Reichenberger, R. Voswinckel, B. Enke, M. Rutsch, E. El Fechtali, T. Schmehl, H. Olschewski, R. Schermuly, N. Weissmann, H. A. Ghofrani, et al.
Long-term treatment with sildenafil in chronic thromboembolic pulmonary hypertension
Eur. Respir. J.,
November 1, 2007;
30(5):
922 - 927.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.C. Vonk, M.H. Sander, F.H.J. van den Hoogen, P.L.C.M. van Riel, F.W.A. Verheugt, and A.P.J. van Dijk
Right ventricle Tei-index: A tool to increase the accuracy of non-invasive detection of pulmonary arterial hypertension in connective tissue diseases
Eur J Echocardiogr,
October 1, 2007;
8(5):
317 - 321.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Hoeper and F. Laenger
Challenging cases in PH
Eur. Respir. Rev.,
August 1, 2007;
16(102):
19 - 23.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. R. Henkens, K. T. B. Mouchaers, H. W. Vliegen, W. J. van der Laarse, C. A. Swenne, A. C. Maan, H. H. M. Draisma, I. Schalij, E. E. van der Wall, M. J. Schalij, et al.
Early changes in rat hearts with developing pulmonary arterial hypertension can be detected with three-dimensional electrocardiography
Am J Physiol Heart Circ Physiol,
August 1, 2007;
293(2):
H1300 - H1307.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. T.-J. Gan, S. Holverda, J. T. Marcus, W. J. Paulus, K. M. Marques, J. G.F. Bronzwaer, J. W. Twisk, A. Boonstra, P. E. Postmus, and A. Vonk-Noordegraaf
Right Ventricular Diastolic Dysfunction and the Acute Effects of Sildenafil in Pulmonary Hypertension Patients
Chest,
July 1, 2007;
132(1):
11 - 17.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Edelman
Clinical Presentation, Differential Diagnosis, and Vasodilator Testing of Pulmonary Hypertension
Seminars in Cardiothoracic and Vascular Anesthesia,
June 1, 2007;
11(2):
110 - 118.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Voskaridou, G. Tsetsos, A. Tsoutsias, E. Spyropoulou, D. Christoulas, and E. Terpos
Pulmonary hypertension in patients with sickle cell/{beta} thalassemia: incidence and correlation with serum N-terminal pro-brain natriuretic peptide concentrations
Haematologica,
June 1, 2007;
92(6):
738 - 743.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. M Engelfriet, M. G J Duffels, T. Moller, E. Boersma, J. G P Tijssen, E. Thaulow, M. A Gatzoulis, and B. J M Mulder
Pulmonary arterial hypertension in adults born with a heart septal defect: the Euro Heart Survey on adult congenital heart disease
Heart,
June 1, 2007;
93(6):
682 - 687.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Perros, P. Dorfmuller, R. Souza, I. Durand-Gasselin, V. Godot, F. Capel, S. Adnot, S. Eddahibi, M. Mazmanian, E. Fadel, et al.
Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension
Eur. Respir. J.,
May 1, 2007;
29(5):
937 - 943.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-X. Wang, F.-R. Zhang, Y.-P. Shang, J.-H. Zhu, X.-D. Xie, Q.-M. Tao, J.-H. Zhu, and J.-Z. Chen
Transplantation of Autologous Endothelial Progenitor Cells May Be Beneficial in Patients With Idiopathic Pulmonary Arterial Hypertension: A Pilot Randomized Controlled Trial
J. Am. Coll. Cardiol.,
April 10, 2007;
49(14):
1566 - 1571.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. McMurtry, R. Moudgil, K. Hashimoto, S. Bonnet, E. D. Michelakis, and S. L. Archer
Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension
Am J Physiol Lung Cell Mol Physiol,
April 1, 2007;
292(4):
L872 - L878.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Sanz, P. Kuschnir, T. Rius, R. Salguero, R. Sulica, A. J. Einstein, S. Dellegrottaglie, V. Fuster, S. Rajagopalan, and M. Poon
Pulmonary Arterial Hypertension: Noninvasive Detection with Phase-Contrast MR Imaging
Radiology,
April 1, 2007;
243(1):
70 - 79.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Jardim, C. E. Rochitte, M. Humbert, G. Rubenfeld, D. Jasinowodolinski, C. R. R. Carvalho, and R. Souza
Pulmonary artery distensibility in pulmonary arterial hypertension: an MRI pilot study
Eur. Respir. J.,
March 1, 2007;
29(3):
476 - 481.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Ryu, M. J. Krowka, K. L. Swanson, P. A. Pellikka, and M. D. McGoon
Pulmonary Hypertension in Patients With Interstitial Lung Diseases
Mayo Clin. Proc.,
March 1, 2007;
82(3):
342 - 350.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G.-P. Diller and M. A. Gatzoulis
Pulmonary Vascular Disease in Adults With Congenital Heart Disease
Circulation,
February 27, 2007;
115(8):
1039 - 1050.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. J. Reesink, M. N. van der Plas, N. E. Verhey, R. P. van Steenwijk, J. J. Kloek, and P. Bresser
Six-minute walk distance as parameter of functional outcome after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension
J. Thorac. Cardiovasc. Surg.,
February 1, 2007;
133(2):
510 - 516.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Hoeper, S. H. Lee, R. Voswinckel, M. Palazzini, X. Jais, A. Marinelli, R. J. Barst, H. A. Ghofrani, Z.-C. Jing, C. Opitz, et al.
Complications of Right Heart Catheterization Procedures in Patients With Pulmonary Hypertension in Experienced Centers
J. Am. Coll. Cardiol.,
December 19, 2006;
48(12):
2546 - 2552.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Armigliato, R. Paolini, S. Aggio, S. Zamboni, M. P. Galasso, P. Zonzin, and G. Cella
Hyperthyroidism as a Cause of Pulmonary Arterial Hypertension: A Prospective Study
Angiology,
October 1, 2006;
57(5):
600 - 606.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Cenedese, R. Speich, L. Dorschner, S. Ulrich, M. Maggiorini, R. Jenni, and M. Fischler
Measurement of quality of life in pulmonary hypertension and its significance
Eur. Respir. J.,
October 1, 2006;
28(4):
808 - 815.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Tamby, M. Humbert, P. Guilpain, A. Servettaz, N. Dupin, J. J. Christner, G. Simonneau, J. Fermanian, B. Weill, L. Guillevin, et al.
Antibodies to fibroblasts in idiopathic and scleroderma-associated pulmonary hypertension
Eur. Respir. J.,
October 1, 2006;
28(4):
799 - 807.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. V. McLaughlin and M. D. McGoon
Pulmonary Arterial Hypertension
Circulation,
September 26, 2006;
114(13):
1417 - 1431.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ulrich, M. Fischler, R. Speich, V. Popov, and M. Maggiorini
Chronic thromboembolic and pulmonary arterial hypertension share acute vasoreactivity properties.
Chest,
September 1, 2006;
130(3):
841 - 846.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Joppa, D. Petrasova, B. Stancak, and R. Tkacova
Systemic Inflammation in Patients With COPD and Pulmonary Hypertension.
Chest,
August 1, 2006;
130(2):
326 - 333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Souza, C. Jardim, and C. Carvalho
The Need for National Registries in Rare Diseases
Am. J. Respir. Crit. Care Med.,
July 15, 2006;
174(2):
228 - 228.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. S. Zabka, F. E. Campbell, and D. W. Wilson
Pulmonary arteriopathy and idiopathic pulmonary arterial hypertension in six dogs.
Vet. Pathol.,
July 1, 2006;
43(4):
510 - 522.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Fijalkowska, M. Kurzyna, A. Torbicki, G. Szewczyk, M. Florczyk, P. Pruszczyk, and M. Szturmowicz
Serum N-Terminal Brain Natriuretic Peptide as a Prognostic Parameter in Patients With Pulmonary Hypertension
Chest,
May 1, 2006;
129(5):
1313 - 1321.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Humbert, O. Sitbon, A. Chaouat, M. Bertocchi, G. Habib, V. Gressin, A. Yaici, E. Weitzenblum, J.-F. Cordier, F. Chabot, et al.
Pulmonary Arterial Hypertension in France: Results from a National Registry
Am. J. Respir. Crit. Care Med.,
May 1, 2006;
173(9):
1023 - 1030.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Tji-Joong Gan, J.-W. Lankhaar, J. T. Marcus, N. Westerhof, K. M. Marques, J. G. F. Bronzwaer, A. Boonstra, P. E. Postmus, and A. Vonk-Noordegraaf
Impaired left ventricular filling due to right-to-left ventricular interaction in patients with pulmonary arterial hypertension
Am J Physiol Heart Circ Physiol,
April 1, 2006;
290(4):
H1528 - H1533.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Scheindlin
When She Says Yes, But He Needs NO: Some Reflections on Nitric Oxide.
Mol. Interv.,
February 1, 2006;
6(1):
8 - 13.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Provencher, D. Chemla, P. Herve, O. Sitbon, M. Humbert, and G. Simonneau
Heart rate responses during the 6-minute walk test in pulmonary arterial hypertension
Eur. Respir. J.,
January 1, 2006;
27(1):
114 - 120.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Galie, H. A. Ghofrani, A. Torbicki, R. J. Barst, L. J. Rubin, D. Badesch, T. Fleming, T. Parpia, G. Burgess, A. Branzi, et al.
Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension
N. Engl. J. Med.,
November 17, 2005;
353(20):
2148 - 2157.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Sitbon, M. Humbert, X. Jais, V. Ioos, A. M. Hamid, S. Provencher, G. Garcia, F. Parent, P. Herve, and G. Simonneau
Long-Term Response to Calcium Channel Blockers in Idiopathic Pulmonary Arterial Hypertension
Circulation,
June 14, 2005;
111(23):
3105 - 3111.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. B. Santana, J. G. Barra, J. C. Grignola, F. F. Gines, and R. L. Armentano
Pulmonary artery smooth muscle activation attenuates arterial dysfunction during acute pulmonary hypertension
J Appl Physiol,
February 1, 2005;
98(2):
605 - 613.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
