CLINICAL RESEARCH: MAGNETIC RESONANCE AND COMPUTED TOMOGRAPHIC IMAGING
The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy
James C. C. Moon, MB, BCh*,
Emma Reed ,
Mary N. Sheppard, FRCPath,
Andrew G. Elkington, MB, BCh*,
SiewYen Ho, PhD, FRCPath ,
Margaret Burke, MB, FRCPath,
Mario Petrou, PhD, FRCS and
Dudley J. Pennell, MD, FRCP, FESC, FACC*,*
* Centre for Advanced Magnetic Resonance in Cardiology (CAMRIC), London, United Kingdom
Department of Histopathology, Royal Brompton and Harefield Hospitals, London, United Kingdom
Department of Paediatrics, Royal Brompton and Harefield Hospitals, London, United Kingdom
Department of Cardiothoracic Surgery, Royal Brompton and Harefield Hospitals, London, United Kingdom
Manuscript received June 18, 2003;
revised manuscript received February 18, 2004,
accepted March 2, 2004.
* Reprint requests and correspondence: Dr. Dudley J. Pennell, Professor of Cardiology, CMR Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United Kingdom.
d.pennell{at}ic.ac.uk
OBJECTIVES: We sought to identify the histologic basis of myocardial late gadolinium enhancement cardiovascular magnetic resonance (CMR) in hypertrophic cardiomyopathy (HCM).
BACKGROUND: The histologic basis of late gadolinium CMR in patients with HCM is unknown.
METHODS: A 28-year-old male patient with HCM and heart failure underwent late gadolinium enhancement CMR and, 49 days later, heart transplantation. The explanted heart was examined histologically for the extent of collagen and disarray, and the results were compared with a previous in vivo CMR scan.
RESULTS: Overall, 19% of the myocardium was collagen, but the amount per segment varied widely (SD ± 19, range 0% to 71%). Both disarray and collagen were more likely to be found in the mesocardium than in the endo- or epicardium. There was a significant relationship between the extent of late gadolinium enhancement and collagen (r = 0.7, p < 0.0001) but not myocardial disarray (p = 0.58). Segments containing >15% collagen were more likely to have late gadolinium enhancement. Regional wall motion was inversely related to the extent of myocardial collagen and late gadolinium enhancement but not disarray (p = 0.0003, 0.04, and NS, respectively).
CONCLUSIONS: In this patient with HCM and heart failure, regions of myocardial late gadolinium enhancement by CMR represented regions of increased myocardial collagen but not disarray.
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Abbreviations and Acronyms
| | CMR | = cardiovascular magnetic resonance | | HCM | = hypertrophic cardiomyopathy | | LV | = left ventricle/ventricular | | RV | = right ventricular |
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