CLINICAL RESEARCH: ATRIAL ANATOMY AND STROKE
Atrial anatomy in non-cardioembolic stroke patients
Effect of medical therapy
Shunichi Homma, MD, FACC*,*,
Ralph L. Sacco, MD, MS ,
Marco R. Di Tullio, MD*,
Robert R. Sciacca, EngScD*,
Jay P. Mohr, MD PICSS Investigators
* Department of Medicine, New York, New York, USA
Neurological Institute, Columbia University, New York, New York, USA
Manuscript received January 9, 2003;
revised manuscript received March 14, 2003,
accepted March 20, 2003.
* Reprint requests and correspondence: Dr. Shunichi Homma, Division of Cardiology, Columbia University, College of Physicians & Surgeons, 630 West 168th Street, New York, New York 10032, USA. sh23{at}columbia.edu
OBJECTIVES: The purpose of the study was to assess the mechanism responsible for increased stroke risk in patients with atrial septal aneurysm (SA) and patent foramen ovale (PFO), and to determine the efficacy of medical therapy for preventing stroke recurrence or death.
BACKGROUND: Atrial septal aneurysm and PFO are associated with stroke. However, the mechanism for this association is undefined, and the efficacy of medical therapy has not been investigated in a randomized fashion.
METHODS: The Patent foramen ovale In Cryptogenic Stroke Study (PICSS) evaluated transesophageal echocardiography findings in patients enrolled in the Warfarin-Aspirin Recurrent Stroke Study, a randomized double-blind trial to evaluate the efficacy of warfarin compared with aspirin.
RESULTS: Large PFO and prominent eustachian valve (EV) or right atrial (RA) filamentous strands were found more frequently in patients with SA compared with those without SA (37.7% vs. 10.9%, p < 0.001 and 59.4% vs. 43.1%, p = 0.02). Patients with SA and PFO had no significant difference in time to recurrent stroke or death compared with those having neither (hazard ratio [HR] 1.08, 95% confidence interval [CI] 0.49 to 2.38, p = 0.84; two-year event rates 15.9% vs. 14.5%). Patients with SA, PFO, and RA anatomy predisposing to paradoxical embolization also had no difference compared with those without these findings (HR 1.22, 95% CI 0.43 to 3.47, p = 0.71; two-year event rates 18.2% vs. 14.2%). There was no significant difference in time to recurrent stroke or death between the patients treated with warfarin or aspirin (HR 1.00, 95% CI 0.22 to 4.47, p = 1.0; two-year event rates 16.0% vs. 15.8%).
CONCLUSIONS: Atrial septal aneurysm is associated with the presence of large PFO and prominent EV or RA filamentous strands. On medical therapy, patients with SA and PFO did not experience increased risk of adverse events, and there was no difference between treatment results for warfarin and for aspirin.
|
Abbreviations and Acronyms
| | EV | = eustachian valve | | INR | = international normalized ratio | | IVC | = inferior vena cava | | PFO | = patent foramen ovale | | PICSS | = Patent foramen ovale In Cryptogenic Stroke Study | | RA | = right atrial | | SA | = atrial septal aneurysm | | TEE | = transesophageal echocardiography | | TIA | = transient ischemic attack | | WARSS | = Warfarin-Aspirin Recurrent Stroke Study |
|
This article has been cited by other articles:

|
 |

|
 |
 
D. N. Salem, P. T. O'Gara, C. Madias, and S. G. Pauker
Valvular and Structural Heart Disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
Chest,
June 1, 2008;
133(6_suppl):
593S - 629S.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. R. Di Tullio, R. L. Sacco, R. R. Sciacca, Z. Jin, and S. Homma
Patent Foramen Ovale and the Risk of Ischemic Stroke in a Multiethnic Population
J. Am. Coll. Cardiol.,
February 20, 2007;
49(7):
797 - 802.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. H. Bonati, A. Kessel-Schaefer, A. Z. Linka, P. Buser, S. G. Wetzel, E.-W. Radue, P. A. Lyrer, and S. T. Engelter
Diffusion-Weighted Imaging in Stroke Attributable to Patent Foramen Ovale: Significance of Concomitant Atrial Septum Aneurysm
Stroke,
August 1, 2006;
37(8):
2030 - 2034.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. R. Kizer and R. B. Devereux
Clinical practice. Patent foramen ovale in young adults with unexplained stroke.
N. Engl. J. Med.,
December 1, 2005;
353(22):
2361 - 2372.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Homma and R. L. Sacco
Patent Foramen Ovale and Stroke
Circulation,
August 16, 2005;
112(7):
1063 - 1072.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F J Pinto
When and how to diagnose patent foramen ovale
Heart,
April 1, 2005;
91(4):
438 - 440.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. W. Schuchlenz
Patent Foramen Ovale and Stroke
Stroke,
June 1, 2004;
35(6):
e135 - e136.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. R. Messe, I. E. Silverman, J. R. Kizer, S. Homma, C. Zahn, G. Gronseth, and S. E. Kasner
Practice Parameter: Recurrent stroke with patent foramen ovale and atrial septal aneurysm: Report of the Quality Standards Subcommittee of the American Academy of Neurology
Neurology,
April 13, 2004;
62(7):
1042 - 1050.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. O'Rourke, N. Dean, N. Akhtar, and A. Shuaib
Current and future concepts in stroke prevention
Can. Med. Assoc. J.,
March 30, 2004;
170(7):
1123 - 1133.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
How Well Does TEE Predict Recurrent Stroke?
Journal Watch Neurology,
November 7, 2003;
2003(1107):
6 - 6.
[Full Text]
|
 |
|

|
 |

|
 |
 
How Well Does TEE Predict Recurrent Stroke?
Journal Watch Cardiology,
October 24, 2003;
2003(1024):
1 - 1.
[Full Text]
|
 |
|
|