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CLINICAL RESEARCH: ACUTE MYOCARDIAL INFARCTION

Beneficial effects of immediate stenting after thrombolysis in acute myocardial infarction

Bruno Scheller, MD^*,*, Benno Hennen, MD^*, Bernd Hammer, MD^*, Jürgen Walle, MD, Christian Hofer, MD, Volker Hilpert, MD, Horst Winter, MD^||, Georg Nickenig, MD^*, Michael Böhm, MD^* SIAM III Study Group

^* Innere Medizin III, Universität des Saarlandes, Homburg/Saar, Germany
Staedtisches Krankenhaus, Neunkirchen/Saar, Germany
Kreiskrankenhaus Ottweiler, Germany
Kreiskrankenhaus St. Ingbert, Germany
^|| Elisabeth Krankenhaus, Zweibrücken, Germany

Manuscript received November 6, 2002; revised manuscript received February 6, 2003, accepted February 13, 2003.

^* Reprint requests and correspondence: Dr. Bruno Scheller, Innere Medizin III (Kardiologie/Angiologie), Universitätskliniken des Saarlandes, Kirrberger Strasse, D 66421, Homburg/Saar, Germany.
bruno.scheller{at}uniklinik-saarland.de

Drs. Scheller and Hennen contributed equally to the work.

OBJECTIVES: The Southwest German Interventional Study in Acute Myocardial Infarction (SIAM III) investigated potentially beneficial effects of immediate stenting after thrombolysis as opposed to a more conservative treatment regimen.

BACKGROUND: Treatment of acute myocardial infarction (AMI) by thrombolysis is compromised by Thrombolysis In Myocardial Infarction (TIMI) 3 flow rates of only 60% and high re-occlusion rates of the infarct-related artery (IRA). Older studies showed no benefit of coronary angioplasty after thrombolysis compared with thrombolytic therapy alone. This observation has been challenged by the superiority of primary stenting over balloon angioplasty in AMI.

METHODS: The SIAM III study was a multicenter, randomized, prospective, controlled trial in patients receiving thrombolysis in AMI (<12 h). Patients of group I were transferred within 6 h after thrombolysis for coronary angiography, including stenting of the IRA. Group II received elective coronary angiography two weeks after thrombolysis with stenting of the IRA.

RESULTS: A total of 197 patients were randomized, 163 patients fulfilled the secondary (angiographic) inclusion criteria (82 in group I, 81 in group II). Immediate stenting was associated with a significant reduction of the combined end point after six months (ischemic events, death, reinfarction, target lesion revascularization 25.6% vs. 50.6%, p = 0.001).

CONCLUSIONS: Immediate stenting after thrombolysis leads to a significant reduction of cardiac events compared with a more conservative approach including delayed stenting after two weeks.

Abbreviations and Acronyms   AMI   acute myocardial infarction   GP   glycoprotein   IRA   infarct-related artery   LV   left ventricular   MI   myocardial infarction   SIAM III   Southwest German Interventional Study in Acute Myocardial Infarction   TIMI   Thrombolysis In Myocardial Infarction

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