HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gotto, A. M. Search for Related Content PubMed PubMed Citation Articles by Gotto, A. M., Jr

VIEWPOINT

Antioxidants, statins, and atherosclerosis

^* Weill Medical College of Cornell University, New York, New York, USA

Manuscript received June 25, 2002; revised manuscript received December 11, 2002, accepted December 25, 2002.

^* Reprint requests and correspondence: Dr. Antonio M. Gotto, Jr, c/o Mr. Jesse Jou, Weill Medical College of Cornell University, 445 East 69th Street, Olin Hall 205, New York, New York 10021, USA.
amg_editorial{at}med.cornell.edu

Research into the oxidation of lipoproteins has yielded many new insights into the pathogenesis of atherosclerosis. However, despite lipoprotein oxidation’s biologically plausible role in atherogenesis, several studies have reported inconsistent effects of antioxidants on clinical coronary end points, in sharp contrast with the studies of lipid modification with the 3-hydroxy-3-methylglutaryl coenzyme A inhibitors, or statins. There appears to be little support for the use of antioxidants in coronary prevention. However, the picture remains incomplete. What are the limitations of available antioxidant studies and the agents used? Until the picture can be clarified, lipid modification with strategies proved to reduce the risk for coronary events, such as statins or dietary changes in the style of the Mediterranean diet, should be better implemented in clinical practice.

Abbreviations and Acronyms   ASAP = Antioxidant Supplementation in Atherosclerosis Prevention study   ATBC = Alpha-Tocopherol-Beta-Carotene cancer prevention study   CAD = coronary artery disease   CHAOS = Cambridge Heart AntiOxidant Study   HATS = High-density lipoprotein Atherosclerosis Treatment Study   HDL-C = high-density lipoprotein cholesterol   LDL = low-density lipoprotein   LDL-C = low-density lipoprotein cholesterol   MI = myocardial infarction   MVP = MultiVitamins and Probucol study   SPACE = Secondary Prevention with Antioxidants of Cardiovascular disease in End-stage renal disease study

This article has been cited by other articles:

				J. F. Oram and J. W. Heinecke ATP-Binding Cassette Transporter A1: A Cell Cholesterol Exporter That Protects Against Cardiovascular Disease Physiol Rev, October 1, 2005; 85(4): 1343 - 1372. [Abstract] [Full Text] [PDF]

				P. H. Stone, D. M. Lloyd-Jones, S. Kinlay, B. Frei, W. Carlson, J. Rubenstein, T. C. Andrews, M. Johnstone, G. Sopko, H. Cole, et al. Effect of Intensive Lipid Lowering, With or Without Antioxidant Vitamins, Compared With Moderate Lipid Lowering on Myocardial Ischemia in Patients With Stable Coronary Artery Disease: The Vascular Basis for the Treatment of Myocardial Ischemia Study Circulation, April 12, 2005; 111(14): 1747 - 1755. [Abstract] [Full Text] [PDF]

				M. Campbell, W. E. Allen, C. Sawyer, B. Vanhaesebroeck, and E. R. Trimble Glucose-Potentiated Chemotaxis in Human Vascular Smooth Muscle Is Dependent on Cross-Talk Between the PI3K and MAPK Signaling Pathways Circ. Res., August 20, 2004; 95(4): 380 - 388. [Abstract] [Full Text] [PDF]

				P. M. Kris-Etherton, A. H. Lichtenstein, B. V. Howard, D. Steinberg, J. L. Witztum, and for the Nutrition Committee of the American Heart Antioxidant Vitamin Supplements and Cardiovascular Disease Circulation, August 3, 2004; 110(5): 637 - 641. [Full Text] [PDF]

				R. S. Eidelman, D. Hollar, P. R. Hebert, G. A. Lamas, and C. H. Hennekens Randomized Trials of Vitamin E in the Treatment and Prevention of Cardiovascular Disease Arch Intern Med, July 26, 2004; 164(14): 1552 - 1556. [Abstract] [Full Text] [PDF]

				F Violi, L Loffredo, L Musella, and A Marcoccia Should antioxidant status be considered in interventional trials with antioxidants? Heart, June 1, 2004; 90(6): 598 - 602. [Abstract] [Full Text] [PDF]

				W. Palinski United They Go: Conjunct Regulation of Aortic Antioxidant Enzymes During Atherogenesis Circ. Res., August 8, 2003; 93(3): 183 - 185. [Full Text] [PDF]