CLINICAL STUDY: CARDIAC IMAGING
Susceptibility-sensitive magnetic resonance imaging detects human myocardium supplied by a stenotic coronary artery without a contrast agent
Christian M. Wacker, MD*,
Andreas W. Hartlep, PhD ,
Stefan Pfleger, MD ,
Lothar R. Schad, PhD,
Georg Ertl, MD* and
Wolfgang R. Bauer, MD, PhD*,*
* Medical Clinic, University of Wuerzburg, Wuerzburg, Germany
Department of Biophysics and Medical Physics, German Cancer Research Center (DKFZ), Heidelberg, Germany
I. Medical Clinic Mannheim, University of Heidelberg, Mannheim, Germany
Manuscript received July 5, 2002;
revised manuscript received September 24, 2002,
accepted October 17, 2002.
* Reprint requests and correspondence: Dr. Wolfgang R. Bauer, Medical Clinic, Department of Cardiology, University of Wuerzburg, Josef-Schneider-Str. 2, 97080 Wuerzburg, Germany.
w.bauer{at}medizin.uni-wuerzburg.de
OBJECTIVES: Evaluation of the severity of a coronary artery stenosis is of paramount importance for therapy. A relevant stenosis provokes post-stenotic microvascular dilation with capillary recruitment. This autoregulatory response was investigated in the present study by use of susceptibility-sensitive magnetic resonance imaging (MRI) without contrast agents.
BACKGROUND: Functional alterations of the microvascular system may be studied noninvasively and without a contrast agent by susceptibility-sensitive MRI, which is based on the paramagnetic property of deoxyhemoglobin. This effect, also referred to as the "blood oxygenation level-dependent (BOLD) effect," is investigated by phase relaxation (T2*) measurements.
METHODS: In patients (n = 16) with single-vessel coronary artery disease, no history of myocardial infarction, normal left ventricular function at rest, and a positive stress echocardiogram, the susceptibility-sensitive parameter T2* was assessed in the myocardium.
RESULTS: In regions associated with the stenotic artery, T2* was significantly lower than in residual myocardium (p < 0.01). This difference in T2* increased after application of the vasodilator dipyridamole (p < 0.001). In patients being re-investigated after therapeutic interventions, the microvascular dilation was partly removed.
CONCLUSIONS: For the first time, we could show that myocardial BOLD MRI detects post-stenotic capillary recruitment dependent on coronary artery stenosis.
|
Abbreviations and Acronyms
| | BOLD | | blood oxygenation level-dependent | | CABG | | coronary artery bypass graft surgery | | CAD | | coronary artery disease | | ECG | | electrocardiographic | | LAD | | left anterior descending coronary artery | | MRI | | magnetic resonance imaging | | PTCA | | percutanous transluminal coronary angioplasty | | ROI | | region of interest | | T2* | | phase relaxation |
|
This article has been cited by other articles:
|
|
|
|
 
D. P. O'Regan, R. Ahmed, N. Karunanithy, C. Neuwirth, Y. Tan, G. Durighel, J. V. Hajnal, I. Nadra, S. J. Corbett, and S. A. Cook
Reperfusion Hemorrhage Following Acute Myocardial Infarction: Assessment with T2* Mapping and Effect on Measuring the Area at Risk
Radiology,
March 1, 2009;
250(3):
916 - 922.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A.-C. Schulte, M. Aschwanden, and D. Bilecen
Calf Muscles at Blood Oxygen Level-Dependent MR Imaging: Aging Effects at Postocclusive Reactive Hyperemia
Radiology,
May 1, 2008;
247(2):
482 - 489.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Indermuhle, R. Vogel, P. Meier, S. Wirth, R. Stoop, M. G. Mohaupt, and C. Seiler
The relative myocardial blood volume differentiates between hypertensive heart disease and athlete's heart in humans
Eur. Heart J.,
July 1, 2006;
27(13):
1571 - 1578.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-P. Ledermann, A.-C. Schulte, H.-G. Heidecker, M. Aschwanden, K. A. Jager, K. Scheffler, W. Steinbrich, and D. Bilecen
Blood Oxygenation Level-Dependent Magnetic Resonance Imaging of the Skeletal Muscle in Patients With Peripheral Arterial Occlusive Disease
Circulation,
June 27, 2006;
113(25):
2929 - 2935.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Shea, D. S. Fieno, B. E. Schirf, X. Bi, J. Huang, R. A. Omary, and D. Li
T2-prepared Steady-State Free Precession Blood Oxygen Level-Dependent MR Imaging of Myocardial Perfusion in a Dog Stenosis Model
Radiology,
August 1, 2005;
236(2):
503 - 509.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Utz, J. Jordan, T. Niendorf, M. Stoffels, F. C. Luft, R. Dietz, and M. G. Friedrich
Blood Oxygen Level-Dependent MRI of Tissue Oxygenation: Relation to Endothelium-Dependent and Endothelium-Independent Blood Flow Changes
Arterioscler. Thromb. Vasc. Biol.,
July 1, 2005;
25(7):
1408 - 1413.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Pennell, U. P. Sechtem, C. B. Higgins, W. J. Manning, G. M. Pohost, F. E. Rademakers, A. C. van Rossum, L. J. Shaw, and E. K. Yucel
Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report
Eur. Heart J.,
November 1, 2004;
25(21):
1940 - 1965.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. S. Fieno, S. M. Shea, Y. Li, K. R. Harris, J. P. Finn, and D. Li
Myocardial Perfusion Imaging Based on the Blood Oxygen Level-Dependent Effect Using T2-Prepared Steady-State Free-Precession Magnetic Resonance Imaging
Circulation,
September 7, 2004;
110(10):
1284 - 1290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. R. Edelman
Contrast-enhanced MR Imaging of the Heart: Overview of the Literature
Radiology,
September 1, 2004;
232(3):
653 - 668.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. G. Friedrich, T. Niendorf, J. Schulz-Menger, C. M. Gross, and R. Dietz
Blood Oxygen Level-Dependent Magnetic Resonance Imaging in Patients with Stress-Induced Angina
Circulation,
November 4, 2003;
108(18):
2219 - 2223.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
