HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Plotnick, G. D. Articles by Wise, J. A. Search for Related Content PubMed PubMed Citation Articles by Plotnick, G. D. Articles by Wise, J. A.

CLINICAL RESEARCH

Effect of supplemental phytonutrients on impairment of the flow-mediated brachialartery vasoactivity after a single high-fat meal

Gary D. Plotnick, MD, FACC^*,*, Mary C. Corretti, MD, FACC^*, Robert A. Vogel, MD, FACC^*, Robert Hesslink, Jr, ScD and John A. Wise, PhD

^* University of Maryland School of Medicine, Baltimore, Maryland, USA
Natural Alternatives International, San Marcos, California, USA

Manuscript received July 2, 2002; revised manuscript received November 25, 2002, accepted January 9, 2003.

^* Reprint requests and correspondence: Dr. Gary D. Plotnick, Cardiology Division, University of Maryland Medical Center, 22 South Greene Street, Baltimore, Maryland 21201, USA.
gplotnic{at}medicine.umaryland.edu

OBJECTIVES: Our objective was to determine if long-term daily administration of phytonutrient supplements can prevent the immediate adverse impact of a high-fat meal and increase the production of nitric oxide.

BACKGROUND: Ingestion of a high-fat meal impairs flow-mediated vasodilation of the brachial artery for at least 4 h; however, co-ingestion of vitamin antioxidants or a green salad has been shown to prevent this effect.

METHODS: Flow-mediated brachial artery reactivity test (BART) both before and 3 h after a 900 calorie 50 g fat meal was evaluated in 38 healthy volunteers (age 36.4 ± 10.1 years). Subjects were randomized to four weeks of daily supplementation with a powdered fruit vegetable juice concentrate (Juice Plus [JP]) along with a complex supplement providing nutritional antioxidants and various herbal extracts (Vineyard [V]), JP alone, or a matching placebo. At three and four weeks, BART was repeated both before and after the high-fat meal. Serum nitrate/nitrite concentrations were measured at baseline and at four weeks.

RESULTS: Four weeks of the JP-V combination blunted the detrimental effect of the high-fat meal (–47.5 ± 23.4% at baseline vs. –1.7 ± 9.7% at four weeks [p < 0.05]). Four weeks of JP alone had a similar beneficial effect (–45.1 ± 19.7% at baseline vs. –16.6 ± 10.3% at four weeks [p < 0.05]), whereas there was no substantial effect of the placebo. In the subjects treated with supplements, concentrations of serum nitrate/nitrite increased from 78 ± 39 to 114 ± 62 µm/l (p < 0.02).

CONCLUSIONS: Daily ingestion of modest amounts of a fruit/vegetable juice concentrate with or without adjunctive phytonutrient supplementation can reduce the immediate adverse impact of high-fat meals on flow-mediated vasoactivity and increase nitrate/nitrite blood concentration.

Abbreviations and Acronyms   BART   brachial artery reactivity test   FMV   flow-mediated vasodilation   JP   Juice Plus   LDL   low-density lipoprotein   NAD(P)H   nicotinamide adenine dinucleotide phosphate (reduced)   NO   nitric oxide   V   Vineyard

This article has been cited by other articles:

				T. A. Barringer, L. Hatcher, and H. C. Sasser Potential Benefits on Impairment of Endothelial Function after a High-fat Meal of 4 weeks of Flavonoid Supplementation Evid. Based Complement. Altern. Med., July 3, 2008; (2008) nen048v1. [Abstract] [Full Text] [PDF]

				M. C. Houston, B. Cooil, B. J. Olafsson, and P. Raggi Juice Powder Concentrate and Systemic Blood Pressure, Progression of Coronary Artery Calcium and Antioxidant Status in Hypertensive Subjects: A Pilot Study Evid. Based Complement. Altern. Med., December 1, 2007; 4(4): 455 - 462. [Abstract] [Full Text] [PDF]

				D. J. A. Jenkins, C. W. C. Kendall, A. R. Josse, S. Salvatore, F. Brighenti, L. S. A. Augustin, P. R. Ellis, E. Vidgen, and A. V. Rao Almonds Decrease Postprandial Glycemia, Insulinemia, and Oxidative Damage in Healthy Individuals J. Nutr., December 1, 2006; 136(12): 2987 - 2992. [Abstract] [Full Text] [PDF]

				E. Paterson, M. H. Gordon, C. Niwat, T. W. George, L. Parr, S. Waroonphan, and J. A. Lovegrove Supplementation with Fruit and Vegetable Soups and Beverages Increases Plasma Carotenoid Concentrations but Does Not Alter Markers of Oxidative Stress or Cardiovascular Risk Factors J. Nutr., November 1, 2006; 136(11): 2849 - 2855. [Abstract] [Full Text] [PDF]

				B. Cortes, I. Nunez, M. Cofan, R. Gilabert, A. Perez-Heras, E. Casals, R. Deulofeu, and E. Ros Acute Effects of High-Fat Meals Enriched With Walnuts or Olive Oil on Postprandial Endothelial Function J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1666 - 1671. [Abstract] [Full Text] [PDF]

				C. J. Abularrage, A. N. Sidawy, G. Aidinian, N. Singh, J. M. Weiswasser, and S. Arora Evaluation of Macrocirculatory Endothelium-Dependent and Endothelium-Independent Vasoreactivity in Vascular Disease Perspectives in Vascular Surgery and Endovascular Therapy, September 1, 2005; 17(3): 245 - 253. [Abstract] [PDF]

				S. Samman Reply to Watzl and Bub J. Nutr., November 1, 2003; 133(11): 3726 - 3726. [Full Text] [PDF]