HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Antzelevitch, C. Articles by Nademanee, K. Search for Related Content PubMed PubMed Citation Articles by Antzelevitch, C. Articles by Nademanee, K.

STATE-OF-THE-ART PAPER

Brugada syndrome: 1992–2002

A historical perspective

Charles Antzelevitch, PhD, FACC^*,*, Pedro Brugada, MD, PhD, Josep Brugada, MD, PhD, Ramon Brugada, MD, FACC^*, Jeffrey A. Towbin, MD, FACC and Kolawanee Nademanee, MD, FACC^||

^* Masonic Medical Research Laboratory, Utica, New York, USA
Cardiovascular Center, OLV Hospital, Aalst, Belgium
Cardiovascular Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain
Pediatrics Department, Section of Cardiology, Baylor College of Medicine, Houston, Texas, USA
^|| Pacific Rim Cardiac Electrophysiology and Research, Inglewood, California, USA

Manuscript received October 30, 2002; revised manuscript received December 20, 2002, accepted January 24, 2003.

^* Reprint requests and correspondence: Dr. Charles Antzelevitch, Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, New York 13501, USA.
ca{at}mmrl.edu

An intriguing new clinical entity characterized by ST-segment elevation in the right precordial electrocardiographic leads and a high incidence of sudden death in individuals with structurally normal hearts was described by Pedro and Josep Brugada in 1992. The past decade has witnessed an exponential rise in the number of reported cases and a dramatic proliferation of papers serving to define the clinical, genetic, cellular, ionic, and molecular aspects of this disease. The purpose of this brief review is to chronicle the historical highlights that have brought us to our present understanding of Brugada syndrome.

Abbreviations and Acronyms   ARVD/C   arrhythmogenic right ventricular dysplasia/cardiomyopathy   ECG   electrocardiogram/electrocardiographic   EPS   electrophysiologic study   ICD   implantable cardioverter-defibrillator   INa   sodium channel current   Ito   transient outward current   RBBB   right bundle branch block   RV   right ventricle/ventricular   RVOT   right ventricular outflow tract   SAECG   signal-averaged electrocardiogram   VF   ventricular fibrillation   VT   ventricular tachycardia

This article has been cited by other articles:

				M. A. Babaee Bigi, A. Aslani, and A. Aslani Significance of cardiac autonomic neuropathy in risk stratification of Brugada syndrome Europace, July 1, 2008; 10(7): 821 - 824. [Abstract] [Full Text] [PDF]

				T. Wichter What role for autonomic dysfunction in Brugada Syndrome? Pathophysiological and prognostic implications Europace, July 1, 2008; 10(7): 782 - 783. [Full Text] [PDF]

				S. Nagase, K. F. Kusano, H. Morita, N. Nishii, K. Banba, A. Watanabe, S. Hiramatsu, K. Nakamura, S. Sakuragi, and T. Ohe Longer Repolarization in the Epicardium at the Right Ventricular Outflow Tract Causes Type 1 Electrocardiogram in Patients With Brugada Syndrome J. Am. Coll. Cardiol., March 25, 2008; 51(12): 1154 - 1161. [Abstract] [Full Text] [PDF]

				A. Pelliccia, F. M. Di Paolo, F. M. Quattrini, C. Basso, F. Culasso, G. Popoli, R. De Luca, A. Spataro, A. Biffi, G. Thiene, et al. Outcomes in Athletes with Marked ECG Repolarization Abnormalities N. Engl. J. Med., January 10, 2008; 358(2): 152 - 161. [Abstract] [Full Text] [PDF]

				I. Six, J.-S. Hermida, H. Huang, L. Gouas, V. Fressart, N. Benammar, B. Hainque, I. Denjoy, M. Chahine, and P. Guicheney The occurrence of Brugada syndrome and isolated cardiac conductive disease in the same family could be due to a single SCN5A mutation or to the accidental association of both diseases Europace, January 1, 2008; 10(1): 79 - 85. [Abstract] [Full Text] [PDF]

				M. Seda, F. M Pinto, S. Wray, C. G Cintado, P. Noheda, H. Buschmann, and L. Candenas Functional and Molecular Characterization of Voltage-Gated Sodium Channels in Uteri from Nonpregnant Rats Biol Reprod, November 1, 2007; 77(5): 855 - 863. [Abstract] [Full Text] [PDF]

				M. Lei, H. Zhang, A. A. Grace, and C. L.-H. Huang SCN5A and sinoatrial node pacemaker function Cardiovasc Res, June 1, 2007; 74(3): 356 - 365. [Abstract] [Full Text] [PDF]

				M. A. Babaee Bigi, A. Aslani, and S. Shahrzad Prevalence of Brugada sign in patients presenting with palpitation in southern Iran Europace, April 1, 2007; 9(4): 252 - 255. [Abstract] [Full Text] [PDF]

				Z.-S. Zhang, J. Tranquillo, V. Neplioueva, N. Bursac, and A. O. Grant Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H399 - H407. [Abstract] [Full Text] [PDF]

				T. Aiba, W. Shimizu, I. Hidaka, K. Uemura, T. Noda, C. Zheng, A. Kamiya, M. Inagaki, M. Sugimachi, and K. Sunagawa Cellular Basis for Trigger and Maintenance of Ventricular Fibrillation in the Brugada Syndrome Model: High-Resolution Optical Mapping Study J. Am. Coll. Cardiol., May 16, 2006; 47(10): 2074 - 2085. [Abstract] [Full Text] [PDF]

				J. Castro Hevia, C. Antzelevitch, F. Tornes Barzaga, M. Dorantes Sanchez, F. Dorticos Balea, R. Zayas Molina, M. A. Quinones Perez, and Y. Fayad Rodriguez Tpeak-Tend and Tpeak-Tend Dispersion as Risk Factors for Ventricular Tachycardia/Ventricular Fibrillation in Patients With the Brugada Syndrome J. Am. Coll. Cardiol., May 2, 2006; 47(9): 1828 - 1834. [Abstract] [Full Text] [PDF]

				D. Darbar, T. Yang, K. Churchwell, A. A.M. Wilde, and D. M. Roden Unmasking of Brugada Syndrome by Lithium Circulation, September 13, 2005; 112(11): 1527 - 1531. [Abstract] [Full Text] [PDF]

				M. Lei, C. Goddard, J. Liu, A.-L. Leoni, A. Royer, S. S.-M. Fung, G. Xiao, A. Ma, H. Zhang, F. Charpentier, et al. Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a J. Physiol., September 1, 2005; 567(2): 387 - 400. [Abstract] [Full Text] [PDF]

				P. Brugada, R. Brugada, J. Brugada, S. G. Priori, C. Napolitano, P. Brugada, R. Brugada, J. Brugada, S. G. Priori, and C. Napolitano Should patients with an asymptomatic Brugada electrocardiogram undergo pharmacological and electrophysiological testing? Circulation, July 12, 2005; 112(2): 279 - 292. [Full Text] [PDF]

				T. Chen, M. Inoue, and M. F. Sheets Reduced voltage dependence of inactivation in the SCN5A sodium channel mutation delF1617 Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2666 - H2676. [Abstract] [Full Text] [PDF]

				T Rossenbacker, E Schollen, C Kuiperi, T J L de Ravel, K Devriendt, G Matthijs, D Collen, H Heidbuchel, and P Carmeliet Unconventional intronic splice site mutation in SCN5A associates with cardiac sodium channelopathy J. Med. Genet., May 1, 2005; 42(5): e29 - e29. [Abstract] [Full Text] [PDF]

				A. Royer, T. A.B. van Veen, S. Le Bouter, C. Marionneau, V. Griol-Charhbili, A.-L. Leoni, M. Steenman, H. V.M. van Rijen, S. Demolombe, C. A. Goddard, et al. Mouse Model of SCN5A-Linked Hereditary Lenegre's Disease: Age-Related Conduction Slowing and Myocardial Fibrosis Circulation, April 12, 2005; 111(14): 1738 - 1746. [Abstract] [Full Text] [PDF]

				J.-S. Hermida, I. Denjoy, G.èv. Jarry, S. Jandaud, C. Bertrand, and J. Delonca Electrocardiographic predictors of Brugada type response during Na channel blockade challenge Europace, January 1, 2005; 7(5): 447 - 453. [Abstract] [Full Text] [PDF]

				K. Hong, J. Brugada, A. Oliva, A. Berruezo-Sanchez, D. Potenza, G. D. Pollevick, A. Guerchicoff, K. Matsuo, E. Burashnikov, R. Dumaine, et al. Value of Electrocardiographic Parameters and Ajmaline Test in the Diagnosis of Brugada Syndrome Caused by SCN5A Mutations Circulation, November 9, 2004; 110(19): 3023 - 3027. [Abstract] [Full Text] [PDF]

				B. Belhassen, A. Glick, and S. Viskin Efficacy of Quinidine in High-Risk Patients With Brugada Syndrome Circulation, September 28, 2004; 110(13): 1731 - 1737. [Abstract] [Full Text] [PDF]

				D. G Katritsis and A.J. Camm Nonsustained ventricular tachycardia: where do we stand? Eur. Heart J., July 1, 2004; 25(13): 1093 - 1099. [Abstract] [Full Text] [PDF]

				B. J. Maron, B. R. Chaitman, M. J. Ackerman, A. Bayes de Luna, D. Corrado, J. E. Crosson, B. J. Deal, D. J. Driscoll, N.A. M. Estes III, C. G. S. Araujo, et al. Recommendations for Physical Activity and Recreational Sports Participation for Young Patients With Genetic Cardiovascular Diseases Circulation, June 8, 2004; 109(22): 2807 - 2816. [Abstract] [Full Text] [PDF]

				A. Oto Brugada sign: a normal variant or a bad omen? Insights for risk stratification and prognostication Eur. Heart J., May 2, 2004; 25(10): 810 - 811. [Full Text] [PDF]

				D. E. Arking, S. S. Chugh, A. Chakravarti, and P. M. Spooner Genomics in Sudden Cardiac Death Circ. Res., April 2, 2004; 94(6): 712 - 723. [Abstract] [Full Text] [PDF]

				J. Ahn and J. W. Hurst Worrisome Thoughts About the Diagnosis and Treatment of Patients With Brugada Waves and the Brugada Syndrome Circulation, March 30, 2004; 109(12): 1463 - 1467. [Abstract] [Full Text] [PDF]

				B Martini More evidence-based data are required for a consensus on the aetiology of the so-called Brugada Syndrome Eur. Heart J., November 2, 2003; 24(22): 2072 - 2072. [Full Text] [PDF]

				A.A.M Wilde and C Antzelevitch The continuing story: The aetiology of Brugada syndrome: functional or structural basis? Eur. Heart J., November 2, 2003; 24(22): 2073 - 2073. [Full Text] [PDF]