CLINICAL STUDY: BIOMARKERS
Plasma brain natriuretic peptide concentration: impact of age and gender
Margaret M. Redfield, MD*,*,
Richard J. Rodeheffer, MD*,
Steven J. Jacobsen, MD, PhD ,
Douglas W. Mahoney, MS ,
Kent R. Bailey, PhD and
John C. Burnett, Jr, MD*
* Division of Cardiovascular Diseases, and Sections of, Rochester, Minnesota, USA
Health Science Research and, Rochester, Minnesota, USA
Biostatistics, Mayo Clinic and Foundation, Rochester, Minnesota, USA
Manuscript received March 4, 2002;
accepted May 31, 2002.
* Reprint requests and correspondence: Dr. Margaret M. Redfield, Guggenheim 9, Mayo Clinic, 200 First Street, Southwest, Rochester, Minnesota 55905, USA.
redfield.margaret{at}mayo.edu
OBJECTIVES: We wished to examine the effects of age and gender on plasma brain natriuretic peptide (BNP) concentration in a population-based study.
BACKGROUND: Measurement of BNP concentration is approved for use in the diagnosis of heart failure and may aid in the detection of left ventricular dysfunction. Although BNP is approved for clinical use, there are few data regarding the range of BNP observed in persons without cardiovascular disease or cardiac dysfunction. These data are essential for the interpretation of BNP.
METHODS: In 2,042 randomly selected residents of Olmsted County, Minnesota, >44 years old, BNP (Shionogi and Biosite assays), Doppler echocardiography, and medical record review were performed. A normal subset of subjects (n = 767) in sinus rhythm without cardiovascular, renal, or pulmonary disease or diabetes; on no cardiovascular medications; and with normal systolic, diastolic, and valvular function was identified.
RESULTS: Within the normal subset, the distribution of BNP differed by age, gender, and assay system. With both assays, BNP increased significantly with age and was significantly higher in women than men, leading to age-, gender-, and assay-specific reference ranges. Receiver operating characteristic analysis for the ability of BNP to detect an ejection fraction  40% was performed in each age/gender stratum in the entire cohort (n = 2,042) and confirmed that discriminatory values for BNP for detection of reduced ejection fraction were higher in women and older persons and were different between the two assays.
CONCLUSIONS: Interpretation of BNP should include consideration of age-, gender-, and assay-specific partition values.
|
Abbreviations and Acronyms
| | BNP | | brain natriuretic peptide | | CHF | | congestive heart failure | | CI | | confidence interval | | E/A | | early-to-late filling velocities | | EF | | ejection fraction | | HRT | | hormone replacement therapy | | LV | | left ventricular | | ROC | | receiver operating characteristic | | 2-D | | two-dimensional |
|
This article has been cited by other articles:
|
|
|
|
 
B. Vaes, W. de Ruijter, J. Gussekloo, and J. Degryse
The accuracy of plasma natriuretic peptide levels for diagnosis of cardiac dysfunction and chronic heart failure in community-dwelling elderly: a systematic review
Age Ageing,
November 1, 2009;
38(6):
655 - 662.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. K. Saenger, D. A. Dalenberg, S. C. Bryant, S. K. Grebe, and A. S. Jaffe
Pediatric Brain Natriuretic Peptide Concentrations Vary with Age and Sex and Appear to Be Modulated by Testosterone
Clin. Chem.,
October 1, 2009;
55(10):
1869 - 1875.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Niizuma, Y. Iwanaga, T. Yahata, Y. Tamaki, Y. Goto, H. Nakahama, and S. Miyazaki
Impact of Left Ventricular End-Diastolic Wall Stress on Plasma B-Type Natriuretic Peptide in Heart Failure with Chronic Kidney Disease and End-Stage Renal Disease
Clin. Chem.,
July 1, 2009;
55(7):
1347 - 1353.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S Dhar, G S Pressman, S Subramanian, S Kaul, S Gollamudi, E J Bloom, and V M Figueredo
Natriuretic peptides and heart failure in the patient with chronic kidney disease: a review of current evidence
Postgrad. Med. J.,
June 1, 2009;
85(1004):
299 - 302.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Moertl, R. Berger, J. Struck, A. Gleiss, A. Hammer, N. G. Morgenthaler, A. Bergmann, M. Huelsmann, and R. Pacher
Comparison of midregional pro-atrial and B-type natriuretic peptides in chronic heart failure: influencing factors, detection of left ventricular systolic dysfunction, and prediction of death.
J. Am. Coll. Cardiol.,
May 12, 2009;
53(19):
1783 - 1790.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L Lorgis, M Zeller, G Dentan, P Sicard, P Buffet, I L'Huillier, J C Beer, M Vincent-Martin, H Makki, P Gambert, et al.
Prognostic value of N-terminal pro-brain natriuretic peptide in elderly people with acute myocardial infarction: prospective observational study
BMJ,
May 6, 2009;
338(may06_1):
b1605 - b1605.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. A. Voors, S. von Haehling, S. D. Anker, H. L. Hillege, J. Struck, O. Hartmann, A. Bergmann, I. Squire, D. J. van Veldhuisen, K. Dickstein, et al.
C-terminal provasopressin (copeptin) is a strong prognostic marker in patients with heart failure after an acute myocardial infarction: results from the OPTIMAAL study
Eur. Heart J.,
May 2, 2009;
30(10):
1187 - 1194.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L Frankenstein, A L Clark, K Goode, L Ingle, A Remppis, D Schellberg, F Grabs, M Nelles, J G F Cleland, H A Katus, et al.
The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age
Heart,
May 1, 2009;
95(10):
825 - 829.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Watanabe, M. Hirayama, A. Noda, M. Ito, N. Atsuta, J. Senda, T. Kaga, A. Yamada, M. Katsuno, T. Niwa, et al.
B-type natriuretic peptide and cardiovalvulopathy in Parkinson disease with dopamine agonist
Neurology,
February 17, 2009;
72(7):
621 - 626.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. W. Troughton and A. M. Richards
B-type natriuretic peptides and echocardiographic measures of cardiac structure and function.
J. Am. Coll. Cardiol. Img.,
February 1, 2009;
2(2):
216 - 225.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. L. Miller, K. A. Hartman, D. E. Grill, J. C. Burnett Jr, and A. S. Jaffe
Only Large Reductions in Concentrations of Natriuretic Peptides (BNP and NT-proBNP) Are Associated with Improved Outcome in Ambulatory Patients with Chronic Heart Failure
Clin. Chem.,
January 1, 2009;
55(1):
78 - 84.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Aijaz, K. A. Ammar, F. Lopez-Jimenez, M. M. Redfield, S. J. Jacobsen, and R. J. Rodeheffer
Abnormal Cardiac Structure and Function in the Metabolic Syndrome: A Population-Based Study
Mayo Clin. Proc.,
December 1, 2008;
83(12):
1350 - 1357.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. H. Drazner, A. S. Hellkamp, C. V. Leier, M. R. Shah, L. W. Miller, S. D. Russell, J. B. Young, R. M. Califf, and A. Nohria
Value of Clinician Assessment of Hemodynamics in Advanced Heart Failure: The ESCAPE Trial
Circ Heart Fail,
September 1, 2008;
1(3):
170 - 177.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Maisel, C. Mueller, K. Adams Jr., S. D. Anker, N. Aspromonte, J. G.F. Cleland, A. Cohen-Solal, U. Dahlstrom, A. DeMaria, S. Di Somma, et al.
State of the art: Using natriuretic peptide levels in clinical practice
Eur J Heart Fail,
September 1, 2008;
10(9):
824 - 839.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. A. Fox, S. K. Shernan, C. D. Collard, K.-Y. Liu, S. F. Aranki, S. M. DeSantis, P. Jarolim, and S. C. Body
Preoperative B-type natriuretic peptide is as independent predictor of ventricular dysfunction and mortality after primary coronary artery bypass grafting.
J. Thorac. Cardiovasc. Surg.,
August 1, 2008;
136(2):
452 - 461.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R S Gabriel, A J Kerr, V Sharma, I S L Zeng, and R A H Stewart
B-type natriuretic peptide and left ventricular dysfunction on exercise echocardiography in patients with chronic aortic regurgitation
Heart,
July 1, 2008;
94(7):
897 - 902.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kataoka and O. Matsuno
Age-Related Pulmonary Crackles (Rales) in Asymptomatic Cardiovascular Patients
Ann. Fam. Med,
May 1, 2008;
6(3):
239 - 245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Weber, M. Burian, I. Dragutinovic, H. Moellmann, H. Nef, A. Elsaesser, V. Mitrovic, C. Hamm, and G. Geisslinger
Genetic polymorphism of the type A human natriuretic peptide receptor (NPR-A) gene contributes to the interindividual variability in the BNP system
Eur J Heart Fail,
May 1, 2008;
10(5):
482 - 489.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Dal-Bianco, A. S. Jaffe, M. R. Bell, and J. K. Oh
Cardiac Function and Brain-Type Natriuretic Peptide in First-Time Flash Pulmonary Edema
Mayo Clin. Proc.,
March 1, 2008;
83(3):
289 - 296.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
National Pulmonary Hypertension Centres of the UK
Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland
Heart,
March 1, 2008;
94(Suppl_1):
i1 - i41.
[Full Text]
[PDF]
|
|
|
|
|
|
|
National Pulmonary Hypertension Centres of the UK
Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland
Thorax,
March 1, 2008;
63(Suppl_2):
ii1 - ii41.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. B. Daniels and A. S. Maisel
Natriuretic Peptides
J. Am. Coll. Cardiol.,
December 18, 2007;
50(25):
2357 - 2368.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O.W. Nielsen, P.J. Cowburn, A. Sajadieh, J.J. Morton, H. Dargie, and T. McDonagh
Value of BNP to estimate cardiac risk in patients on cardioactive treatment in primary care
Eur J Heart Fail,
December 1, 2007;
9(12):
1178 - 1185.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Nybo, M. Benn, R. Mogelvang, J. S. Jensen, P. Schnohr, J. F. Rehfeld, and J. P. Goetze
Impact of Hemoglobin on Plasma Pro-B-Type Natriuretic Peptide Concentrations in the General Population
Clin. Chem.,
November 1, 2007;
53(11):
1921 - 1927.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Mogelvang, J. P. Goetze, P. Schnohr, P. Lange, P. Sogaard, J. F. Rehfeld, and J. S. Jensen
Discriminating Between Cardiac and Pulmonary Dysfunction in the General Population With Dyspnea by Plasma Pro-B-Type Natriuretic Peptide
J. Am. Coll. Cardiol.,
October 23, 2007;
50(17):
1694 - 1701.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. V Parikh, S. M Abdullah, E. C Keeley, J. E Cigarroa, T. A Addo, J. J Warner, A. Khera, J. A De Lemos, and D. K McGuire
Effect of glucose-insulin-potassium (GIK) infusion on biomarkers of cardiovascular risk in ST elevation myocardial infarction (STEMI): insight into the failure of GIK
Diabetes and Vascular Disease Research,
September 1, 2007;
4(3):
222 - 225.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Hogenhuis, A. A. Voors, T. Jaarsma, A. W. Hoes, H. L. Hillege, J. A. Kragten, and D. J. van Veldhuisen
Anaemia and renal dysfunction are independently associated with BNP and NT-proBNP levels in patients with heart failure
Eur J Heart Fail,
August 1, 2007;
9(8):
787 - 794.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Cortes, M. Rivera, A. Salvador, V. Bertomeu, F. G. de Burgos, E. Rosello-Lleti, M. Portoles, R. Paya, L. Martinez-Dolz, and V. Climent
Variability of NT-proBNP plasma and urine levels in patients with stable heart failure: a 2-year follow-up study
Heart,
August 1, 2007;
93(8):
957 - 962.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. S. Apple, A. H.B. Wu, A. S. Jaffe, M. Panteghini, R. H. Christenson, NACB COMMITTEE MEMBERS, R. H. Christenson, F. S. Apple, C. P. Cannon, G. Francis, et al.
National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: Analytical Issues for Biomarkers of Heart Failure
Circulation,
July 31, 2007;
116(5):
e95 - e98.
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.H. Wilson Tang, G. S. Francis, D. A. Morrow, L. K. Newby, C. P. Cannon, R. L. Jesse, A. B. Storrow, R. H. Christenson, COMMITTEE MEMBERS, R. H. Christenson, et al.
National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Utilization of Cardiac Biomarker Testing in Heart Failure
Circulation,
July 31, 2007;
116(5):
e99 - e109.
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. L. Miller, K. A. Hartman, M. F. Burritt, D. E. Grill, R. J. Rodeheffer, J. C. Burnett Jr, and A. S. Jaffe
Serial Biomarker Measurements in Ambulatory Patients With Chronic Heart Failure: The Importance of Change Over Time
Circulation,
July 17, 2007;
116(3):
249 - 257.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Lee and T. H. Marwick
Assessment of subclinical left ventricular dysfunction in asymptomatic mitral regurgitation
Eur J Echocardiogr,
June 1, 2007;
8(3):
175 - 184.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Tsutamoto, H. Sakai, C. Ishikawa, M. Fujii, T. Tanaka, T. Yamamoto, H. Takashima, M. Ohnishi, A. Wada, and M. Horie
Direct comparison of transcardiac difference between brain natriuretic peptide (BNP) and N-terminal pro-BNP in patients with chronic heart failure
Eur J Heart Fail,
June 1, 2007;
9(6-7):
667 - 673.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Choi, D. Park, S. Lee, Y. Hong, S. Kim, and J. Lee
Cut-off values of B-type natriuretic peptide for the diagnosis of congestive heart failure in patients with dyspnoea visiting emergency departments: a study on Korean patients visiting emergency departments
Emerg. Med. J.,
May 1, 2007;
24(5):
343 - 347.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Ammar, S. J. Jacobsen, D. W. Mahoney, J. A. Kors, M. M. Redfield, J. C. Burnett Jr, and R. J. Rodeheffer
Prevalence and Prognostic Significance of Heart Failure Stages: Application of the American College of Cardiology/American Heart Association Heart Failure Staging Criteria in the Community
Circulation,
March 27, 2007;
115(12):
1563 - 1570.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S.P. Lam, J. C. Burnett Jr, L. Costello-Boerrigter, R. J. Rodeheffer, and M. M. Redfield
Alternate Circulating Pro-B-Type Natriuretic Peptide and B-Type Natriuretic Peptide Forms in the General Population
J. Am. Coll. Cardiol.,
March 20, 2007;
49(11):
1193 - 1202.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. H. Leuchte, M. El Nounou, J. C. Tuerpe, B. Hartmann, R. A. Baumgartner, M. Vogeser, O. Muehling, and J. Behr
N-terminal Pro-Brain Natriuretic Peptide and Renal Insufficiency as Predictors of Mortality in Pulmonary Hypertension
Chest,
February 1, 2007;
131(2):
402 - 409.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Y. Chang, S. M. Abdullah, T. Jain, H. G. Stanek, S. R. Das, D. K. McGuire, R. J. Auchus, and J. A. de Lemos
Associations Among Androgens, Estrogens, and Natriuretic Peptides in Young Women: Observations From the Dallas Heart Study
J. Am. Coll. Cardiol.,
January 2, 2007;
49(1):
109 - 116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Mathai and P. M. Hassoun
N-terminal brain natriuretic peptide in scleroderma-associated pulmonary arterial hypertension
Eur. Heart J.,
January 1, 2007;
28(1):
140 - 141.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Rothenbacher, W. Koenig, and H. Brenner
Comparison of N-Terminal Pro-B-Natriuretic Peptide, C-Reactive Protein, and Creatinine Clearance for Prognosis in Patients With Known Coronary Heart Disease
Arch Intern Med,
December 11, 2006;
166(22):
2455 - 2460.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Goetze, R. Mogelvang, L. Maage, H. Scharling, P. Schnohr, P. Sogaard, J. F. Rehfeld, and J. S. Jensen
Plasma pro-B-type natriuretic peptide in the general population: screening for left ventricular hypertrophy and systolic dysfunction
Eur. Heart J.,
December 2, 2006;
27(24):
3004 - 3010.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Braunschweig, A. Fahrleitner-Pammer, M. Mangiavacchi, S. Ghio, P. Fotuhi, U. C. Hoppe, and C. Linde
Correlation between serial measurements of N-terminal pro brain natriuretic peptide and ambulatory cardiac filling pressures in outpatients with chronic heart failure
Eur J Heart Fail,
December 1, 2006;
8(8):
797 - 803.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Bursi, S. A. Weston, M. M. Redfield, S. J. Jacobsen, S. Pakhomov, V. T. Nkomo, R. A. Meverden, and V. L. Roger
Systolic and diastolic heart failure in the community.
JAMA,
November 8, 2006;
296(18):
2209 - 2216.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Christ, K. Laule-Kilian, W. Hochholzer, T. Klima, T. Breidthardt, A. P. Perruchoud, and C. Mueller
Gender-Specific Risk Stratification With B-Type Natriuretic Peptide Levels in Patients With Acute Dyspnea: Insights From the B-type Natriuretic Peptide for Acute Shortness of Breath Evaluation Study
J. Am. Coll. Cardiol.,
November 7, 2006;
48(9):
1808 - 1812.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Jelic and T. H. Le Jemtel
Diagnostic Usefulness of B-Type Natriuretic Peptide and Functional Consequences of Muscle Alterations in COPD and Chronic Heart Failure.
Chest,
October 1, 2006;
130(4):
1220 - 1230.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Shelton, A. L. Clark, K. Goode, A. S. Rigby, and J. G.F. Cleland
The diagnostic utility of N-terminal pro-B-type natriuretic peptide for the detection of major structural heart disease in patients with atrial fibrillation
Eur. Heart J.,
October 1, 2006;
27(19):
2353 - 2361.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. M. Felker, J. W. Petersen, and D. B. Mark
Natriuretic peptides in the diagnosis and management of heart failure.
Can. Med. Assoc. J.,
September 12, 2006;
175(6):
611 - 617.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Muscari, A. Berzigotti, G. Bianchi, C. Giannoni, A. Ligabue, D. Magalotti, D. Sbano, A. Zacchini, and M. Zoli
Non-cardiac determinants of NT-proBNP levels in the elderly: Relevance of haematocrit and hepatic steatosis
Eur J Heart Fail,
August 1, 2006;
8(5):
468 - 476.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Weber and C. Hamm
Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine.
Heart,
June 1, 2006;
92(6):
843 - 849.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Vasan
Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations
Circulation,
May 16, 2006;
113(19):
2335 - 2362.
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. O. Neverdal, C. W. Knudsen, T. Husebye, O. A. Vengen, J. Pepper, M. Lie, and T. Tonnessen
The effect of aortic valve replacement on plasma B-type natriuretic peptide in patients with severe aortic stenosis -- one year follow-up
Eur J Heart Fail,
May 1, 2006;
8(3):
257 - 262.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. M. McKie, R. J. Rodeheffer, A. Cataliotti, F. L. Martin, L. H. Urban, D. W. Mahoney, S. J. Jacobsen, M. M. Redfield, and J. C. Burnett Jr
Amino-Terminal Pro-B-Type Natriuretic Peptide and B-Type Natriuretic Peptide: Biomarkers for Mortality in a Large Community-Based Cohort Free of Heart Failure
Hypertension,
May 1, 2006;
47(5):
874 - 880.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. V. St. Peter, G. G. Hartley, M. M. Murakami, and F. S. Apple
B-Type Natriuretic Peptide (BNP) and N-Terminal Pro-BNP in Obese Patients without Heart Failure: Relationship to Body Mass Index and Gastric Bypass Surgery
Clin. Chem.,
April 1, 2006;
52(4):
680 - 685.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Nohria and M. M. Givertz
B-Type Natriuretic Peptide and the Stressed Heart
J. Am. Coll. Cardiol.,
February 21, 2006;
47(4):
749 - 751.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Januzzi, R. van Kimmenade, J. Lainchbury, A. Bayes-Genis, J. Ordonez-Llanos, M. Santalo-Bel, Y. M. Pinto, and M. Richards
NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1256 patients: The International Collaborative of NT-proBNP Study
Eur. Heart J.,
February 1, 2006;
27(3):
330 - 337.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. C. Costello-Boerrigter, G. Boerrigter, M. M. Redfield, R. J. Rodeheffer, L. H. Urban, D. W. Mahoney, S. J. Jacobsen, D. M. Heublein, and J. C. Burnett Jr
Amino-Terminal Pro-B-Type Natriuretic Peptide and B-Type Natriuretic Peptide in the General Community: Determinants and Detection of Left Ventricular Dysfunction
J. Am. Coll. Cardiol.,
January 17, 2006;
47(2):
345 - 353.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Richards, M. G. Nicholls, E. A. Espiner, J. G. Lainchbury, R. W. Troughton, J. Elliott, C. M. Frampton, I. G. Crozier, T. G. Yandle, R. Doughty, et al.
Comparison of B-Type Natriuretic Peptides for Assessment of Cardiac Function and Prognosis in Stable Ischemic Heart Disease
J. Am. Coll. Cardiol.,
January 3, 2006;
47(1):
52 - 60.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. I.W. Galasko, S. C. Barnes, P. Collinson, A. Lahiri, and R. Senior
What is the most cost-effective strategy to screen for left ventricular systolic dysfunction: natriuretic peptides, the electrocardiogram, hand-held echocardiography, traditional echocardiography, or their combination?
Eur. Heart J.,
January 2, 2006;
27(2):
193 - 200.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Talens-Visconti, M. Rivera Otero, M. J. Sancho-Tello, F. G. de Burgos, L. Martinez-Dolz, B. Sevilla, V. Climent, R. Cortes, A. Salvador, F. Sogorb, et al.
Left ventricular cavity area reflects N-terminal pro-brain natriuretic peptide plasma levels in heart failure
Eur J Echocardiogr,
January 1, 2006;
7(1):
45 - 52.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Clerico, F. A. Recchia, C. Passino, and M. Emdin
Cardiac endocrine function is an essential component of the homeostatic regulation network: physiological and clinical implications
Am J Physiol Heart Circ Physiol,
January 1, 2006;
290(1):
H17 - H29.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kubanek, I. Malek, J. Kautzner, M. Hegarova, M. Wiendl, P. Lupinek, L. Karasova, and V. Lanska
The value of B-type natriuretic peptide and big endothelin-1 for detection of severe pulmonary hypertension in heart transplant candidates
Eur J Heart Fail,
December 1, 2005;
7(7):
1149 - 1155.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. I.W. Galasko, A. Lahiri, S. C. Barnes, P. Collinson, and R. Senior
What is the normal range for N-terminal pro-brain natriuretic peptide? How well does this normal range screen for cardiovascular disease?
Eur. Heart J.,
November 1, 2005;
26(21):
2269 - 2276.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Redfield, S. J. Jacobsen, B. A. Borlaug, R. J. Rodeheffer, and D. A. Kass
Age- and Gender-Related Ventricular-Vascular Stiffening: A Community-Based Study
Circulation,
October 11, 2005;
112(15):
2254 - 2262.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. W. Knudsen, T. Omland, P. Clopton, A. Westheim, A. H.B. Wu, P. Duc, J. McCord, R. M. Nowak, J. E. Hollander, A. B. Storrow, et al.
Impact of Atrial Fibrillation on the Diagnostic Performance of B-Type Natriuretic Peptide Concentration in Dyspneic Patients: An Analysis From the Breathing Not Properly Multinational Study
J. Am. Coll. Cardiol.,
September 6, 2005;
46(5):
838 - 844.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kupari, H. Turto, J. Lommi, M. Makijarvi, and H. Parikka
Transcardiac gradients of N-terminal B-type natriuretic peptide in aortic valve stenosis
Eur J Heart Fail,
August 1, 2005;
7(5):
809 - 814.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. M. McKie and J. C. Burnett Jr
B-Type Natriuretic Peptide as a Biomarker Beyond Heart Failure: Speculations and Opportunities
Mayo Clin. Proc.,
August 1, 2005;
80(8):
1029 - 1036.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Luchner, C. Hengstenberg, H. Lowel, G. A.J. Riegger, H. Schunkert, and S. Holmer
Effect of Compensated Renal Dysfunction on Approved Heart Failure Markers: Direct Comparison of Brain Natriuretic Peptide (BNP) and N-Terminal Pro-BNP
Hypertension,
July 1, 2005;
46(1):
118 - 123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T.v. Lukowicz, M. Fischer, H.W. Hense, A. Doring, J. Stritzke, G. Riegger, H. Schunkert, and A. Luchner
BNP as a marker of diastolic dysfunction in the general population: Importance of left ventricular hypertrophy
Eur J Heart Fail,
June 1, 2005;
7(4):
525 - 531.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Detaint, D. Messika-Zeitoun, J.-F. Avierinos, C. Scott, H. Chen, J. C. Burnett Jr, and M. Enriquez-Sarano
B-Type Natriuretic Peptide in Organic Mitral Regurgitation: Determinants and Impact on Outcome
Circulation,
May 10, 2005;
111(18):
2391 - 2397.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Bar-Oz, A. Lev-Sagie, I. Arad, L. Salpeter, and A. Nir
N-Terminal pro-B-Type Natriuretic Peptide Concentrations in Mothers just before Delivery, in Cord Blood, and in Newborns
Clin. Chem.,
May 1, 2005;
51(5):
926 - 927.
[Full Text]
[PDF]
|
|
|
|
|
|
|
G I W Galasko, R Senior, and A Lahiri
Ethnic differences in the prevalence and aetiology of left ventricular systolic dysfunction in the community: the Harrow heart failure watch
Heart,
May 1, 2005;
91(5):
595 - 600.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Mueller, A Gegenhuber, W Poelz, and M Haltmayer
Diagnostic accuracy of B type natriuretic peptide and amino terminal proBNP in the emergency diagnosis of heart failure
Heart,
May 1, 2005;
91(5):
606 - 612.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ala-Kopsala, H. Ruskoaho, J. Leppaluoto, L. Seres, R. Skoumal, M. Toth, F. Horkay, and O. Vuolteenaho
Single Assay for Amino-Terminal Fragments of Cardiac A- and B-Type Natriuretic Peptides
Clin. Chem.,
April 1, 2005;
51(4):
708 - 718.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. S. Wittstein, D. R. Thiemann, J. A.C. Lima, K. L. Baughman, S. P. Schulman, G. Gerstenblith, K. C. Wu, J. J. Rade, T. J. Bivalacqua, and H. C. Champion
Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress
N. Engl. J. Med.,
February 10, 2005;
352(6):
539 - 548.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Schnabel, H. J. Rupprecht, K. J. Lackner, E. Lubos, C. Bickel, J. Meyer, T. Munzel, F. Cambien, L. Tiret, S. Blankenberg, et al.
Analysis of N-terminal-pro-brain natriuretic peptide and C-reactive protein for risk stratification in stable and unstable coronary artery disease: results from the AtheroGene study
Eur. Heart J.,
February 1, 2005;
26(3):
241 - 249.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Silva, A. W. Chan, C. J. White, T. J. Collins, J. S. Jenkins, J. P. Reilly, and S. R. Ramee
Elevated Brain Natriuretic Peptide Predicts Blood Pressure Response After Stent Revascularization in Patients With Renal Artery Stenosis
Circulation,
January 25, 2005;
111(3):
328 - 333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Pritchett, D. W. Mahoney, S. J. Jacobsen, R. J. Rodeheffer, B. L. Karon, and M. M. Redfield
Diastolic dysfunction and left atrial volume: A population-based study
J. Am. Coll. Cardiol.,
January 4, 2005;
45(1):
87 - 92.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Goetze, J. F. Rehfeld, R. Videbaek, L. Friis-Hansen, and J. Kastrup
B-type natriuretic peptide and its precursor in cardiac venous blood from failing hearts
Eur J Heart Fail,
January 1, 2005;
7(1):
69 - 74.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Hogenhuis, A. A. Voors, T. Jaarsma, H. L. Hillege, F. Boomsma, and D. J. van Veldhuisen
Influence of age on natriuretic peptides in patients with chronic heart failure: a comparison between ANP/NT-ANP and BNP/NT-proBNP
Eur J Heart Fail,
January 1, 2005;
7(1):
81 - 86.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Nordmeyer, S. Eder, S. Mahmoodzadeh, P. Martus, J. Fielitz, J. Bass, N. Bethke, H. R. Zurbrugg, R. Pregla, R. Hetzer, et al.
Upregulation of Myocardial Estrogen Receptors in Human Aortic Stenosis
Circulation,
November 16, 2004;
110(20):
3270 - 3275.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. McCord, B. J. Mundy, M. P. Hudson, A. S. Maisel, J. E. Hollander, W. T. Abraham, P. G. Steg, T. Omland, C. W. Knudsen, K. R. Sandberg, et al.
Relationship Between Obesity and B-Type Natriuretic Peptide Levels
Arch Intern Med,
November 8, 2004;
164(20):
2247 - 2252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Jayachandran, H. Okano, R. Chatrath, W. G. Owen, J. P. McConnell, and V. M. Miller
Sex-specific changes in platelet aggregation and secretion with sexual maturity in pigs
J Appl Physiol,
October 1, 2004;
97(4):
1445 - 1452.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Jernberg, S. James, B. Lindahl, N. Johnston, M. Stridsberg, P. Venge, and L. Wallentin
Natriuretic peptides in unstable coronary artery disease
Eur. Heart J.,
September 1, 2004;
25(17):
1486 - 1493.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Jaffe, F. S. Apple, and L. Babuin
Why We Don't Know the Answer May Be More Important than the Specific Question
Clin. Chem.,
September 1, 2004;
50(9):
1495 - 1497.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Rodeheffer
Measuring plasma B-type natriuretic peptide in heart failure: Good to go in 2004?
J. Am. Coll. Cardiol.,
August 18, 2004;
44(4):
740 - 749.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Cochet, M. Zeller, Y. Cottin, C. Robert-Valla, A. Lalande, I. L'Huilllier, A. Comte, P. M. Walker, J. Desgres, J.-E. Wolf, et al.
The extent of myocardial damage assessed by contrast-enhanced MRI is a major determinant of N-BNP concentration after myocardial infarction
Eur J Heart Fail,
August 1, 2004;
6(5):
555 - 560.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
