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CLINICAL STUDY

Demographics and correlates of five-year change in echocardiographic left ventricular mass in young black and white adult men and women: the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Julius M. Gardin, MD^*,*, Debra Brunner, MA, Pamela J. Schreiner, PhD, Xiaoyuan Xie, MD, Cheryl L. Reid, MD^*, Karen Ruth, MS, Diane E. Bild, MD, PhD, MPH^|| and Samuel S. Gidding, MD^¶

^* Division of Cardiology, Department of Medicine, University of California, Irvine, California, USA
Division of Epidemiology, Department of Medicine, University of California, Irvine, California, USA
Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA
Department of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois, USA
^|| Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA
^¶ Nemours Cardiac Center, A. I. DuPont Hospital for Children, Wilmington, Delaware, USA

Manuscript received August 7, 2000; revised manuscript received April 2, 2002, accepted April 30, 2002.

^* Reprint requests and correspondence: Dr. Julius M. Gardin, Division of Cardiology, St. John Hospital & Medical Center, 22201 Moross Road, PBII, Suite 470, Detroit, Michigan 48236, USA.
Julius.gardin{at}stjohn.org

OBJECTIVES: The goal of this study was to determine the presence and correlates of change () in left ventricular (LV) mass by echocardiography in young adults.

BACKGROUND: Left ventricular mass is known to be a powerful independent predictor for cardiovascular disease events in adults. However, little is known about in LV mass over time in young adults.

METHODS: Coronary Artery Risk Development in Young Adults (CARDIA) is a multicenter, longitudinal, population-based study of black and white men and women who were ages 23 to 35 at the time of their initial two-dimensionally directed M-mode echocardiography exam (year 5); half the cohort had a repeat echocardiography exam five years later (year 10). Data were analyzed from 1,189 participants who had paired echocardiography studies. To minimize reader variability, blinded measurements on initial and repeat echocardiography were performed nearly contemporaneously by the same reader.

RESULTS: In multilinear regression analyses, significant (p < 0.05) predictors of year 10 two-dimensional guided M-mode LV mass included initial LV mass, initial body mass index (BMI) and change in BMI for all race/gender subgroups. Initial systolic blood pressure (SBP) was a significant predictor of year 10 LV mass in white men and black women; change in SBP was significant in black women with a trend towards significance in white women. Left ventricular mass remained constant in all race/gender subgroups, except black women, where it increased (by 5.9 g [mean]). Black women also had the largest increases in BMI and SBP. In black women, a five-year weight gain of 20 pounds and a 15-mm Hg increase in SBP would be expected to be associated with a 9% to 12% increase in LV mass.

CONCLUSIONS: Particularly in black women, weight and blood pressure control may be important community health and treatment goals to prevent LV hypertrophy.

Abbreviations and Acronyms   BMI   body mass index   BP   blood pressure   CARDIA   Coronary Artery Risk Development in Young Adults study   CVD   cardiovascular disease   DBP   diastolic blood pressure   EU   exercise units   LV   left ventricle or left ventricular   SBP   systolic blood pressure      change   2D   two-dimensional

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