CLINICAL STUDY: CARDIAC SURGERY
A comparison of cardiac troponin T and creatine kinase-MB for patient evaluation after cardiac surgery
James L. Januzzi, Jr, MD*,
Kent Lewandrowski, MD ,
Thomas E. MacGillivray, MD ,
John B. Newell, AB,
Sekar Kathiresan, MD*,
Stephen J. Servoss, MD* and
Elizabeth Lee-Lewandrowski, PhD, MPH,*
* Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
Clinical Chemistry Laboratories, Massachusetts General Hospital, Boston, Massachusetts, USA
Cardiac Surgery Division, Massachusetts General Hospital, Boston, Massachusetts, USA
Manuscript received September 6, 2001;
revised manuscript received January 30, 2002,
accepted February 6, 2002.
* Reprint requests and correspondence: Dr. Elizabeth Lee-Lewandrowski, Clinical Chemistry Laboratories, Massachusetts General Hospital, Gray-Bigelow 5, 55 Fruit Street, Boston, Massachusetts 02114, USA.
ELewandrowski{at}Partners.org
OBJECTIVES: The aim of this study was to assess the role of serum markers of myocardial necrosis after cardiac surgery.
BACKGROUND: The role of serum troponin T (TnT) and creatine kinase-MB (CK-MB) for the risk stratification of patients after cardiac surgery remains undefined.
METHODS: Serum levels of TnT and CK-MB were measured from 224 patients every 8 h after cardiac surgery. The results of serum cardiac marker testing were correlated with adverse events, including new myocardial infarction (MI), cardiogenic shock or death. Univariable analysis identified factors predictive of complications, while stepwise logistic regression identified independent predictors of postoperative complications.
RESULTS: Cardiac marker elevation was universal after cardiac surgery. At all time points measured, compared with those patients without complications, the TnT levels from patients with complications were more significantly elevated (all: p < 0.0005). In contrast, among identically timed specimens, the levels of CK-MB from complicated patients were less reliably discriminatory. Multivariable analysis suggested that a TnT level in the highest quintile ( 1.58 ng/ml) was the strongest predictor of complications, including death (post-op, odds ratio [OR] = 31.0, 95% confidence interval [CI] = 3.67 to 263.1, p = 0.002) or shock (post-op: OR = 18.9, 95% CI = 2.29 to 156.1, p = 0.006; 18 h to 24 h: OR = 30.7, 95% CI = 3.75 to 250.7, p = 0.001), as well as the composite end points of death/MI (18 h to 24 h: OR = 60.1, 95% CI = 7.34 to 492.1, p < 0.0005), shock/MI (post-op: OR = 23.3, 95% CI = 2.82 to 191.4, p = 0.003; 18 h to 24 h: OR = 37.8, 95% CI = 4.66 to 307.3, p = 0.001) or death/shock/MI (post-op: OR = 20.0, 95% CI = 2.81 to 142.0, p = 0.003; 18 h to 24 h: OR = 67.4, 95% CI = 6.96 to 652.3, p < 0.0005). In contrast, in the presence of TnT, the results of CK-MB measurement added no independent prognostic information.
CONCLUSIONS: Troponin T is superior to CK-MB for the prediction of impending complications after cardiac surgical procedures.
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Abbreviations and Acronyms
| | CABG | | coronary artery bypass graft | | CI | | confidence interval | | CK-MB | | creatine kinase-MB | | ICU | | intensive care unit | | MI | | myocardial infarction | | OR | | odds ratio | | TnT | | troponin T |
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