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REVIEW ARTICLE

N-acetylcysteine in acute cardiology: 10 years later

What do we know and what would we like to know?!

^* Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Manuscript received April 16, 2001; revised manuscript received January 17, 2002, accepted February 8, 2002.

^* Reprint requests and correspondence: Dr. Jan Sochman, Intensive Care Unit, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague 4, Czech Republic.
jan.sochman{at}medicon.cz

N-acetylcysteine (NAC) is known in a variety of branches of medicine. This paper addresses in detail the action of NAC as it is emerging from research and clinical trials over the past decade in cardiology, giving rise to new concepts. The result is a process resembling creation of a mosaic from individual pieces. Also, the role of NAC in acute cardiology, during acute reperfusion in particular, is defined.

Abbreviations and Acronyms   GISSI   Gruppo Italiano per lo Studio della Streptochinasi nell’ Infarto Miocardico study   GUSTO   Global Utilization of Streptokinase and T-PA for Occluded Coronary Artery trial   ISIS   International Study of Infarct Survival   ISLAND   Infarct Size Limitation: Acute N-acetylcysteine Defense trial   MPG   mercaptopropionyl glycine   NAC   N-acetylcysteine   -SH   sulfhydryl groups

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