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CLINICAL STUDY: INTERVENTIONAL CARDIOLOGY

Efficacy and safety of percutaneous treatment of iatrogenic femoral artery pseudoaneurysm by biodegradable collagen injection

^a Heart Lung Center, Utrecht, The Netherlands
^b Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands

Manuscript received September 25, 2001; revised manuscript received January 16, 2002, accepted January 28, 2002.

^* Reprint requests and correspondence: Dr. Karim Hamraoui, Department of Cardiology, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands.
khamraoui{at}freeler.nl

OBJECTIVES: The goal of this study was to assess the safety and efficacy of femoral artery pseudoaneurysm (FAP) closure by collagen injection.

BACKGROUND: The FAP is an infrequent but troublesome complication after percutaneous transfemoral catheter procedures. If ultrasound-guided compression repair (UGCR) fails, vascular surgery is indicated. We have developed a less invasive method to close FAPs percutaneously by injecting collagen and, thus, inducing clotting within the aneurysm.

METHODS: Via a 9F needle or 11F sheath, a biodegradable adhesive bovine collagen is injected percutaneously into the FAP, guided by angiography from the contralateral site.

RESULTS: From 1993 to 2000, compression and UGCR had failed to obliterate 110 FAPs. These patients have been treated by collagen injection. Mean age of the patients was 65.6 ± 10.2 years (range: 32 to 85 years), and 50% were women. Immediate closure of the FAP was achieved in 107/110 patients (97.3%) without any complication or adverse effect. In one patient the collagen could not be applied due to unfavorable anatomy. One patient needed a second session of collagen injection. In one patient too much collagen was inserted, which resulted in external compression of the artery, and surgical intervention was required. The overall success rate was 108/110 (98%, 95% confidence interval: 93.5% to 99.8%). Among the patients with successful procedures, there were no recurrences during six months follow-up.

CONCLUSIONS: The percutaneous treatment of iatrogenic FAP, by injection with collagen, is an effective and safe strategy. This method provides an excellent therapeutic alternative to the traditional surgical management.

Abbreviations and Acronyms   CI   confidence interval   FAP   femoral artery pseudoaneurysm   UGCR   ultrasound-guided compression repair

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