CLINICAL STUDY: ATHEROSCLEROSIS
Soluble intercellular adhesion molecule-1 and long-term risk of acute coronary events in patients with chronic coronary heart disease
Data from the Bezafibrate Infarction Prevention (BIP) Study
Moti Haim, MD* ,*,
David Tanne, MD*  ,
Valentina Boyko, MSc*,
Tamar Reshef, MSc*,
Uri Goldbourt, PhD*,
Jonathan Leor, MD*,
Yoseph A. Mekori, MD* and
Solomon Behar, MD*
* Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Department of Medicine and the Laboratory of Allergy and Clinical Immunology, Meir General Hospital, Kfar-Saba, Israel
Neufeld Cardiac Research Institute, Sheba Medical Center, Tel-Hashomer, Israel
Stroke Unit, Sheba Medical Center, Tel-Hashomer, Israel
Manuscript received August 23, 2001;
revised manuscript received December 26, 2001,
accepted January 10, 2002.
* Reprint requests and correspondence: Dr. Moti Haim, Cardiology Department, Rabin Medical Center, Beilinson Campus, Jabotinsky Street, Petach-Tikva 49100, Israel
motih{at}netvision.net.il
OBJECTIVES: The goal of this study was to assess soluble intercellular adhesion molecule-1 (sICAM-1) level as a predictor of future acute coronary events in patients with chronic coronary heart disease (CHD).
BACKGROUND: Increased sICAM-1 concentration has been shown to be associated with the incidence of CHD in healthy persons. Its significance in patients with CHD has been scarcely investigated.
METHODS: We designed a prospective, nested case-control study. Sera were collected from patients with CHD enrolled in a secondary prevention trial that evaluated the efficacy of bezafibrate in reducing coronary events. We measured baseline sICAM-1 concentration in the sera of patients who developed subsequent cardiovascular events (cases: n = 136) during follow-up (mean: 6.2 years) and in age- and gender-matched controls (without events: n = 136).
RESULTS: Baseline serum concentrations of sICAM-1 were significantly higher in cases versus controls (375 vs. 350 ng/ml; p < 0.05). Each 100 ng/ml increase in sICAM-1 concentration was associated with 1.27 (95% confidence interval [CI]: 1.00 to 1.63) higher relative odds of coronary events. Soluble ICAM-1 concentration in the highest quartile (>394 ng/ml) was associated with significantly higher odds of coronary events (compared with the lowest quartile), even after multivariate adjustment (2.31, 95% CI: 1.02 to 5.50). After adding fibrinogen and total white blood cell count to the multivariate model, the relative odds were 2.12 (95% CI: 0.88 to 5.35) and 2.70 (95% CI: 1.10 to 7.05), respectively.
CONCLUSIONS: Elevated sICAM-1 concentration in CHD patients is associated with increased risk of future coronary events independent of other traditional risk factors.
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Abbreviations and Acronyms
| | BIP | | Bezafibrate Infarction Prevention study | | CHD | | coronary heart disease | | CI | | confidence interval | | HDL-C | | high-density lipoprotein cholesterol | | LDL-C | | low-density lipoprotein cholesterol | | MI | | myocardial infarction | | OR | | odds ratio | | sICAM-1 | | soluble intercellular adhesion molecule-1 | | VCAM-1 | | vascular cell adhesion molecule-1 |
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