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J Am Coll Cardiol, 2002; 39:257-265 © 2002 by the American College of Cardiology Foundation |
* Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
University of Calgary, Calgary, Alberta, Canada
Boston University School of Medicine, Boston, Massachusetts, USA
Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
|| Royal Victoria Hospital, Montreal, Quebec, Canada
¶ Vascular Diagnostic Laboratory Cardiac Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA
# Vascular Physiology Unit, Great Ormond Street Hospital, London, United Kingdom
** Department of Cardiology and Angiology, Medizinische Hochscule, Hannover, Germany
Departments of Internal Medicine and Cardiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
University College, London, United Kingdom
Manuscript received January 10, 2001; revised manuscript received September 18, 2001, accepted October 19, 2001.
* Reprint requests and correspondence: Dr. Mary C. Corretti, Department of Medicine, Division of Cardiology, University of Maryland School of Medicine, 22 South Greene Street, Gudelsky Tower Room G3K17, Baltimore, Maryland 21201-1595, USA.
mcorrett{at}medicine.umaryland.edu
Endothelial function is thought to be an important factor in the pathogenesis of atherosclerosis, hypertension and heart failure. In the 1990s, high-frequency ultrasonographic imaging of the brachial artery to assess endothelium-dependent flow-mediated vasodilation (FMD) was developed. The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of vasomotor function. The noninvasive nature of the technique allows repeated measurements over time to study the effectiveness of various interventions that may affect vascular health. However, despite its widespread use, there are technical and interpretive limitations of this technique. State-of-the-art information is presented and insights are provided into the strengths and limitations of high-resolution ultrasonography of the brachial artery to evaluate vasomotor function, with guidelines for its research application in the study of endothelial physiology.
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