CLINICAL STUDY: TECHNIQUE REPORT
Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery
A report of the International Brachial Artery Reactivity Task Force
Mary C. Corretti, MD, FACC*,*,
Todd J. Anderson, MD ,
Emelia J. Benjamin, MD, MSc ,
David Celermajer, MD ,
Francois Charbonneau, MD||,
Mark A. Creager, MD¶,
John Deanfield, MD#,
Helmut Drexler, MD**,
Marie Gerhard-Herman, MD¶,
David Herrington, MD, MHS,
Patrick Vallance, MD,
Joseph Vita, MD and
Robert Vogel, MD*
* Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
University of Calgary, Calgary, Alberta, Canada
Boston University School of Medicine, Boston, Massachusetts, USA
Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
|| Royal Victoria Hospital, Montreal, Quebec, Canada
¶ Vascular Diagnostic Laboratory Cardiac Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA
# Vascular Physiology Unit, Great Ormond Street Hospital, London, United Kingdom
** Department of Cardiology and Angiology, Medizinische Hochscule, Hannover, Germany
Departments of Internal Medicine and Cardiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
University College, London, United Kingdom
Manuscript received January 10, 2001;
revised manuscript received September 18, 2001,
accepted October 19, 2001.
* Reprint requests and correspondence: Dr. Mary C. Corretti, Department of Medicine, Division of Cardiology, University of Maryland School of Medicine, 22 South Greene Street, Gudelsky Tower Room G3K17, Baltimore, Maryland 21201-1595, USA.
mcorrett{at}medicine.umaryland.edu
Endothelial function is thought to be an important factor in the pathogenesis of atherosclerosis, hypertension and heart failure. In the 1990s, high-frequency ultrasonographic imaging of the brachial artery to assess endothelium-dependent flow-mediated vasodilation (FMD) was developed. The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of vasomotor function. The noninvasive nature of the technique allows repeated measurements over time to study the effectiveness of various interventions that may affect vascular health. However, despite its widespread use, there are technical and interpretive limitations of this technique. State-of-the-art information is presented and insights are provided into the strengths and limitations of high-resolution ultrasonography of the brachial artery to evaluate vasomotor function, with guidelines for its research application in the study of endothelial physiology.
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Abbreviations and Acronyms
| | ECG | | electrocardiogram/electrocardiographic | | eNOS | | endothelial nitric oxide synthase | | FMD | | flow-mediated vasodilation | | NO | | nitric oxide | | NOS | | nitric oxide synthase | | NTG | | nitroglycerin | | 2D | | two-dimensional |
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|
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|
|
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|
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107(4):
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|
|
|
|
|
|
|
O. Tarcin, D. G. Yavuz, B. Ozben, A. Telli, A. V. Ogunc, M. Yuksel, A. Toprak, D. Yazici, S. Sancak, O. Deyneli, et al.
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
C. Antoniades, T. Van-Assche, C. Shirodaria, J. Diesch, A. S. Antonopoulos, J. Lee, C. Cunnington, D. Tousoulis, C. Stefanadis, B. Casadei, et al.
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120(11_suppl_1):
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|
|
|
|
|
|
|
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Identification of Risk Factors Related to Poor Angiogenic Potency of Bone Marrow Cells From Different Patients
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September 15, 2009;
120(11_suppl_1):
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|
|
|
|
|
|
|
A. Cittadini, L. Saldamarco, A. M. Marra, M. Arcopinto, G. Carlomagno, M. Imbriaco, D. Del Forno, C. Vigorito, B. Merola, U. Oliviero, et al.
Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction
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94(9):
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Black, N. T. Cable, D. H. J. Thijssen, and D. J. Green
Impact of age, sex, and exercise on brachial artery flow-mediated dilatation
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September 1, 2009;
297(3):
H1109 - H1116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Nozaki, S. Sugiyama, H. Koga, K. Sugamura, K. Ohba, Y. Matsuzawa, H. Sumida, K. Matsui, H. Jinnouchi, and H. Ogawa
Significance of a multiple biomarkers strategy including endothelial dysfunction to improve risk stratification for cardiovascular events in patients at high risk for coronary heart disease.
J. Am. Coll. Cardiol.,
August 11, 2009;
54(7):
601 - 608.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Payvandi, A. Dyer, D. McPherson, P. Ades, J. Stein, K. Liu, L. Ferrucci, M. H Criqui, J. M Guralnik, D. Lloyd-Jones, et al.
Physical activity during daily life and brachial artery flow-mediated dilation in peripheral arterial disease
Vascular Medicine,
August 1, 2009;
14(3):
193 - 201.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. J. Azurmendi, A. R. Fraga, F. M. Galan, C. Kotliar, E. E. Arrizurieta, M. G. Valdez, P. J. Forcada, J. S. S. Stefan, and R. S. Martin
Early renal and vascular changes in ADPKD patients with low-grade albumin excretion and normal renal function
Nephrol. Dial. Transplant.,
August 1, 2009;
24(8):
2458 - 2463.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. S Rallidis, J. Lekakis, A. Kolomvotsou, A. Zampelas, G. Vamvakou, S. Efstathiou, G. Dimitriadis, S. A Raptis, and D. T Kremastinos
Close adherence to a Mediterranean diet improves endothelial function in subjects with abdominal obesity
Am. J. Clinical Nutrition,
August 1, 2009;
90(2):
263 - 268.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Klosinska, T. Rudzinski, P. Grzelak, L. Stefanczyk, J. Drozdz, and M. Krzeminska-Pakula
Endothelium-dependent and -independent vasodilation is more attenuated in ischaemic than in non-ischaemic heart failure
Eur J Heart Fail,
August 1, 2009;
11(8):
765 - 770.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. M. Tinken, D. H.J. Thijssen, N. Hopkins, M. A. Black, E. A. Dawson, C. T. Minson, S. C. Newcomer, M. H. Laughlin, N. T. Cable, and D. J. Green
Impact of Shear Rate Modulation on Vascular Function in Humans
Hypertension,
August 1, 2009;
54(2):
278 - 285.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Aizawa, J. K. Shoemaker, T. J. Overend, and R. J. Petrella
Metabolic syndrome, endothelial function and lifestyle modification
Diabetes and Vascular Disease Research,
July 1, 2009;
6(3):
181 - 189.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Shuto, Y. Taketani, R. Tanaka, N. Harada, M. Isshiki, M. Sato, K. Nashiki, K. Amo, H. Yamamoto, Y. Higashi, et al.
Dietary Phosphorus Acutely Impairs Endothelial Function
J. Am. Soc. Nephrol.,
July 1, 2009;
20(7):
1504 - 1512.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Lavi, A. Karasik, N. Koren-Morag, H. Kanety, M. S. Feinberg, and M. Shechter
The acute effect of various glycemic index dietary carbohydrates on endothelial function in nondiabetic overweight and obese subjects.
J. Am. Coll. Cardiol.,
June 16, 2009;
53(24):
2283 - 2287.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Shechter, S. Matetzky, M. Arad, M. S. Feinberg, and D. Freimark
Vascular endothelial function predicts mortality risk in patients with advanced ischaemic chronic heart failure
Eur J Heart Fail,
June 1, 2009;
11(6):
588 - 593.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Peluffo, P. Calcerrada, L. Piacenza, N. Pizzano, and R. Radi
Superoxide-mediated inactivation of nitric oxide and peroxynitrite formation by tobacco smoke in vascular endothelium: studies in cultured cells and smokers
Am J Physiol Heart Circ Physiol,
June 1, 2009;
296(6):
H1781 - H1792.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. H.J. Thijssen, E. A. Dawson, T. M. Tinken, N. T. Cable, and D. J. Green
Retrograde Flow and Shear Rate Acutely Impair Endothelial Function in Humans
Hypertension,
June 1, 2009;
53(6):
986 - 992.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A Cypiene, M Kovaite, A Venalis, J Dadoniene, R Rugiene, Z Petrulioniene, L Ryliskyte, and A Laucevicius
Arterial wall dysfunction in systemic lupus erythematosus
Lupus,
May 1, 2009;
18(6):
522 - 529.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Y. Yeh, J. Doupis, S. Rahangdale, S. Horr, A. Malhotra, and A. Veves
Total serum bilirubin does not affect vascular reactivity in patients with diabetes
Vascular Medicine,
May 1, 2009;
14(2):
129 - 136.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. C. Lavallee, J. Labreuche, F. Gongora-Rivera, A. Jaramillo, D. Brenner, I. F Klein, P.-J. Touboul, E. Vicaut, P. Amarenco, and on behalf of the Lacunar-B.I.C.H.A.T. Investigator
Placebo-Controlled Trial of High-Dose Atorvastatin in Patients With Severe Cerebral Small Vessel Disease
Stroke,
May 1, 2009;
40(5):
1721 - 1728.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Lederer, S. Jelic, R. C. Basner, A. Ishizaka, and J. Bhattacharya
Circulating KL-6, a biomarker of lung injury, in obstructive sleep apnoea
Eur. Respir. J.,
April 1, 2009;
33(4):
793 - 796.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Vona, G.M. Codeluppi, T. Iannino, E. Ferrari, J. Bogousslavsky, and L.K. von Segesser
Effects of Different Types of Exercise Training Followed by Detraining on Endothelium-Dependent Dilation in Patients With Recent Myocardial Infarction
Circulation,
March 31, 2009;
119(12):
1601 - 1608.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J Aizer, E. Karlson, L. Chibnik, K. Costenbader, D Post, M. Liang, V Gall, and M. Gerhard-Herman
A controlled comparison of brachial artery flow mediated dilation (FMD) and digital pulse amplitude tonometry (PAT) in the assessment of endothelial function in systemic lupus erythematosus
Lupus,
March 1, 2009;
18(3):
235 - 242.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Luque-Ramirez, C. Mendieta-Azcona, J. M del Rey Sanchez, M. Maties, and H. F Escobar-Morreale
Effects of an antiandrogenic oral contraceptive pill compared with metformin on blood coagulation tests and endothelial function in women with the polycystic ovary syndrome: influence of obesity and smoking
Eur. J. Endocrinol.,
March 1, 2009;
160(3):
469 - 480.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Napoli, V. Apuzzi, G. Bosso, C. D'Anna, A. De Sena, C. Pirozzi, A. Marano, G. A. Lupoli, G. Cudemo, U. Oliviero, et al.
Recombinant Human Thyrotropin Enhances Endothelial-Mediated Vasodilation of Conduit Arteries
J. Clin. Endocrinol. Metab.,
March 1, 2009;
94(3):
1012 - 1016.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A J Flammer, N T T Vo, B Ledergerber, F Hermann, A Gamperli, A Huttner, J Evison, I Baumgartner, M Cavassini, D Hayoz, et al.
Effect of atazanavir versus other protease inhibitor-containing antiretroviral therapy on endothelial function in HIV-infected persons: randomised controlled trial
Heart,
March 1, 2009;
95(5):
385 - 390.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. P. van der Zwan, T. Teerlink, J. M. Dekker, R. M. A. Henry, C. D. A. Stehouwer, C. Jakobs, R. J. Heine, and P. G. Scheffer
Circulating oxidized LDL: determinants and association with brachial flow-mediated dilation
J. Lipid Res.,
February 1, 2009;
50(2):
342 - 349.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. E. Umpierrez, D. Smiley, G. Robalino, L. Peng, A. E. Kitabchi, B. Khan, A. Le, A. Quyyumi, V. Brown, and L. S. Phillips
Intravenous Intralipid-Induced Blood Pressure Elevation and Endothelial Dysfunction in Obese African-Americans with Type 2 Diabetes
J. Clin. Endocrinol. Metab.,
February 1, 2009;
94(2):
609 - 614.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Villa, B. Costantini, R. Suriano, C. Perri, F. Macri, L. Ricciardi, S. Panunzi, and A. Lanzone
The Differential Effect of the Phytoestrogen Genistein on Cardiovascular Risk Factors in Postmenopausal Women: Relationship with the Metabolic Status
J. Clin. Endocrinol. Metab.,
February 1, 2009;
94(2):
552 - 558.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. M Dickinson, J. B Keogh, and P. M Clifton
Effects of a low-salt diet on flow-mediated dilatation in humans
Am. J. Clinical Nutrition,
February 1, 2009;
89(2):
485 - 490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Bilora, M. T. Sartori, E. Zanon, E. Campagnolo, M. Arzenton, and A. Rossato
Flow-Mediated Arterial Dilation in Primary Antiphospholipid Syndrome
Angiology,
February 1, 2009;
60(1):
104 - 107.
[Abstract]
[PDF]
|
|
|
|
|
|
|
N. Prasad, S. Kumar, A. Singh, A. Sinha, K. Chawla, A. Gupta, R.K. Sharma, N. Sinha, and A. Kapoor
CAROTID INTIMAL THICKNESS AND FLOW-MEDIATED DILATATION IN DIABETIC AND NONDIABETIC CONTINUOUS AMBULATORY PERITONEAL DIALYSIS PATIENTS
Perit. Dial. Int.,
February 1, 2009;
29(Supplement_2):
S96 - S101.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. McDermott, P. Ades, J. M. Guralnik, A. Dyer, L. Ferrucci, K. Liu, M. Nelson, D. Lloyd-Jones, L. Van Horn, D. Garside, et al.
Treadmill Exercise and Resistance Training in Patients With Peripheral Arterial Disease With and Without Intermittent Claudication: A Randomized Controlled Trial
JAMA,
January 14, 2009;
301(2):
165 - 174.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. A. Tyldum, I. E. Schjerve, A. E. Tjonna, I. Kirkeby-Garstad, T. O. Stolen, R. S. Richardson, and U. Wisloff
Endothelial dysfunction induced by post-prandial lipemia: complete protection afforded by high-intensity aerobic interval exercise.
J. Am. Coll. Cardiol.,
January 13, 2009;
53(2):
200 - 206.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Bjarnegard, H. J Arnqvist, T.;r. Lindstro;m, L. Jonasson, and T. Lanne
Long-term hyperglycaemia impairs vascular smooth muscle cell function in women with type 1 diabetes mellitus
Diabetes and Vascular Disease Research,
January 1, 2009;
6(1):
25 - 31.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. E. J. Lott, C. Hogeman, M. Herr, M. Bhagat, A. Kunselman, and L. I. Sinoway
Vasoconstrictor responses in the upper and lower limbs to increases in transmural pressure
J Appl Physiol,
January 1, 2009;
106(1):
302 - 310.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. Widlansky
Shear stress and flow-mediated dilation: all shear responses are not created equally
Am J Physiol Heart Circ Physiol,
January 1, 2009;
296(1):
H31 - H32.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. J. Lott, C. Hogeman, M. Herr, M. Bhagat, and L. I. Sinoway
Sex differences in limb vasoconstriction responses to increases in transmural pressures
Am J Physiol Heart Circ Physiol,
January 1, 2009;
296(1):
H186 - H194.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Eickhoff, A. Valipour, D. Kiss, M. Schreder, L. Cekici, K. Geyer, R. Kohansal, and O. C. Burghuber
Determinants of Systemic Vascular Function in Patients with Stable Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med.,
December 15, 2008;
178(12):
1211 - 1218.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Tentolouris, C. Arapostathi, D. Perrea, D. Kyriaki, C. Revenas, and N. Katsilambros
Differential Effects of Two Isoenergetic Meals Rich in Saturated or Monounsaturated Fat on Endothelial Function in Subjects With Type 2 Diabetes
Diabetes Care,
December 1, 2008;
31(12):
2276 - 2278.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Teragawa, Y. Higashi, and Y. Kihara
Effect of isoflavone supplement on endothelial function: does efficacy vary with atherosclerotic burden?
Eur. Heart J.,
November 2, 2008;
29(22):
2710 - 2712.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M Title, E. Lonn, F. Charbonneau, M. Fung, K. J Mather, S. Verma, and T. J Anderson
Relationship between brachial artery flow-mediated dilatation, hyperemic shear stress, and the metabolic syndrome
Vascular Medicine,
November 1, 2008;
13(4):
263 - 270.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K de Leeuw, J Blaauw, A. Smit, C. Kallenberg, and M Bijl
Vascular responsiveness in the microcirculation of patients with systemic lupus erythematosus is not impaired
Lupus,
November 1, 2008;
17(11):
1010 - 1017.
[Abstract]
[PDF]
|
|
|
|
|
|
|
V. Rudolph, T. K. Rudolph, F. J. Schopfer, G. Bonacci, D. Lau, K. Szocs, A. Klinke, T. Meinertz, B. A. Freeman, and S. Baldus
Bivalirudin Decreases NO Bioavailability by Vascular Immobilization of Myeloperoxidase
J. Pharmacol. Exp. Ther.,
November 1, 2008;
327(2):
324 - 331.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. K. Nishiyama, D. W. Wray, and R. S. Richardson
Aging affects vascular structure and function in a limb-specific manner
J Appl Physiol,
November 1, 2008;
105(5):
1661 - 1670.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. F. Mitchell
Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage
J Appl Physiol,
November 1, 2008;
105(5):
1652 - 1660.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Pries, H. Habazettl, G. Ambrosio, P. R. Hansen, J. C. Kaski, V. Schachinger, H. Tillmanns, G. Vassalli, I. Tritto, M. Weis, et al.
A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings
Cardiovasc Res,
November 1, 2008;
80(2):
165 - 174.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Soltesz, H. Der, K. Veres, R. Laczik, S. Sipka, G. Szegedi, and P. Szodoray
Immunological features of primary anti-phospholipid syndrome in connection with endothelial dysfunction
Rheumatology,
November 1, 2008;
47(11):
1628 - 1634.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. M. Tinken, D. H. J. Thijssen, M. A. Black, N. T. Cable, and D. J. Green
Time course of change in vasodilator function and capacity in response to exercise training in humans
J. Physiol.,
October 15, 2008;
586(20):
5003 - 5012.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Pirro, F. Bagaglia, L. Paoletti, R. Razzi, and M. R. Mannarino
Review: Hypercholesterolemia-associated endothelial progenitor cell dysfunction
Therapeutic Advances in Cardiovascular Disease,
October 1, 2008;
2(5):
329 - 339.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Westphal, C. Abletshauser, and C. Luley
Fluvastatin Treatment and Withdrawal: Effects on Endothelial Function
Angiology,
October 1, 2008;
59(5):
613 - 618.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. E. E. Berry, S. Tucker, R. Banerji, B. Jiang, P. J. Chowienczyk, S. M. Charles, and T. A. B. Sanders
Impaired Postprandial Endothelial Function Depends on the Type of Fat Consumed by Healthy Men
J. Nutr.,
October 1, 2008;
138(10):
1910 - 1914.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. H. J. Thijssen, M. M. van Bemmel, L. M. Bullens, E. A. Dawson, N. D. Hopkins, T. M. Tinken, M. A. Black, M. T. E. Hopman, N. T. Cable, and D. J. Green
The impact of baseline diameter on flow-mediated dilation differs in young and older humans
Am J Physiol Heart Circ Physiol,
October 1, 2008;
295(4):
H1594 - H1598.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Thurston, K. Sutton-Tyrrell, S. A. Everson-Rose, R. Hess, and K. A. Matthews
Hot Flashes and Subclinical Cardiovascular Disease: Findings From the Study of Women's Health Across the Nation Heart Study
Circulation,
September 16, 2008;
118(12):
1234 - 1240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Abbatecola, M. Barbieri, M. R. Rizzo, R. Grella, M. T. Laieta, E. Quaranta, A. M. Molinari, M. Cioffi, P. Fioretto, and G. Paolisso
Arterial Stiffness and Cognition in Elderly Persons With Impaired Glucose Tolerance and Microalbuminuria
J. Gerontol. A Biol. Sci. Med. Sci.,
September 1, 2008;
63(9):
991 - 996.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Romualdi, B. Costantini, L. Selvaggi, M. Giuliani, F. Cristello, F. Macri, A. Bompiani, A. Lanzone, and M. Guido
Metformin improves endothelial function in normoinsulinemic PCOS patients: a new prospective
Hum. Reprod.,
September 1, 2008;
23(9):
2127 - 2133.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. K. Nishiyama, D. W. Wray, and R. S. Richardson
Sex and limb-specific ischemic reperfusion and vascular reactivity
Am J Physiol Heart Circ Physiol,
September 1, 2008;
295(3):
H1100 - H1108.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Sugiura, T. Kondo, Y. Kureishi-Bando, Y. Numaguchi, O. Yoshida, Y. Dohi, G. Kimura, R. Ueda, T. J. Rabelink, and T. Murohara
Nifedipine Improves Endothelial Function: Role of Endothelial Progenitor Cells
Hypertension,
September 1, 2008;
52(3):
491 - 498.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. J. Torriani, L. Komarow, R. A. Parker, B. R. Cotter, J. S. Currier, M. P. Dube, C. J. Fichtenbaum, M. Gerschenson, C. K.C. Mitchell, R. L. Murphy, et al.
Endothelial Function in Human Immunodeficiency Virus-Infected Antiretroviral-Naive Subjects Before and After Starting Potent Antiretroviral Therapy: The ACTG (AIDS Clinical Trials Group) Study 5152s
J. Am. Coll. Cardiol.,
August 12, 2008;
52(7):
569 - 576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Dhindsa, S. M. Sommerlad, A. E. DeVan, J. N. Barnes, J. Sugawara, O. Ley, and H. Tanaka
Interrelationships among noninvasive measures of postischemic macro- and microvascular reactivity
J Appl Physiol,
August 1, 2008;
105(2):
427 - 432.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. T. Minson and D. J. Green
Measures of vascular reactivity: prognostic crystal ball or Pandora's box?
J Appl Physiol,
August 1, 2008;
105(2):
398 - 399.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Karatzi, C. Papamichael, E. Karatzis, T. G. Papaioannou, P. Th. Voidonikola, G. D. Vamvakou, J. Lekakis, and A. Zampelas
Postprandial Improvement of Endothelial Function by Red Wine and Olive Oil Antioxidants: A Synergistic Effect of Components of the Mediterranean Diet
J. Am. Coll. Nutr.,
August 1, 2008;
27(4):
448 - 453.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Anastasakis, K. I. Paraskevas, N. Papantoniou, G. Daskalakis, S. Mesogitis, D. P. Mikhailidis, and A. Antsaklis
Association Between Abnormal Uterine Artery Doppler Flow Velocimetry, Risk of Preeclampsia, and Indices of Arterial Structure and Function: A Pilot Study
Angiology,
August 1, 2008;
59(4):
493 - 499.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. R. Rabelo, K. Ruschel, H. Moreno Jr., M. Rubira, F. M. Consolim-Colombo, M. C. Irigoyen, and L. E. Rohde
Venous endothelial function in heart failure: Comparison with healthy controls and effect of clinical compensation
Eur J Heart Fail,
August 1, 2008;
10(8):
758 - 764.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Mannarino and M. Pirro
Endothelial Injury and Repair: A Novel Theory for Atherosclerosis
Angiology,
August 1, 2008;
59(2_suppl):
69S - 72S.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Juonala, J. S.A. Viikari, M. Kahonen, T. Solakivi, H. Helenius, A. Jula, J. Marniemi, L. Taittonen, T. Laitinen, T. Nikkari, et al.
Childhood Levels of Serum Apolipoproteins B and A-I Predict Carotid Intima-Media Thickness and Brachial Endothelial Function in Adulthood: The Cardiovascular Risk in Young Finns Study
J. Am. Coll. Cardiol.,
July 22, 2008;
52(4):
293 - 299.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Tjonna, S. J. Lee, O. Rognmo, T. O. Stolen, A. Bye, P. M. Haram, J. P. Loennechen, Q. Y. Al-Share, E. Skogvoll, S. A. Slordahl, et al.
Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome: A Pilot Study
Circulation,
July 22, 2008;
118(4):
346 - 354.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Khan
Commentary on Viewpoint: The human cutaneous circulation as a model of generalized microvascular function
J Appl Physiol,
July 1, 2008;
105(1):
385 - 385.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Fernhall and S. Agiovlasitis
Arterial function in youth: window into cardiovascular risk
J Appl Physiol,
July 1, 2008;
105(1):
325 - 333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Moro, C. Pedone, S. Scarlata, V. Malafarina, F. Fimognari, and R. Antonelli-Incalzi
Endothelial Dysfunction in Chronic Obstructive Pulmonary Disease
Angiology,
July 1, 2008;
59(3):
357 - 364.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. Belardinelli, F. Lacalaprice, C. Ventrella, L. Volpe, and E. Faccenda
Waltz Dancing in Patients With Chronic Heart Failure: New Form of Exercise Training
Circ Heart Fail,
July 1, 2008;
1(2):
107 - 114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. L. Hall, N. L. Formanuik, D. Harnpanich, M. Cheung, D. Talbot, P. J. Chowienczyk, and T. A. B. Sanders
A Meal Enriched with Soy Isoflavones Increases Nitric Oxide-Mediated Vasodilation in Healthy Postmenopausal Women
J. Nutr.,
July 1, 2008;
138(7):
1288 - 1292.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Rakobowchuk, S. Tanguay, K. A. Burgomaster, K. R. Howarth, M. J. Gibala, and M. J. MacDonald
Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow-mediated dilation in healthy humans
Am J Physiol Regulatory Integrative Comp Physiol,
July 1, 2008;
295(1):
R236 - R242.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Aittokallio, O. Polo, J. Hiissa, A. Virkki, J. Toikka, O. Raitakari, T. Saaresranta, and T. Aittokallio
Overnight variability in transcutaneous carbon dioxide predicts vascular impairment in women
Exp Physiol,
July 1, 2008;
93(7):
880 - 891.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ashfaq, J. L. Abramson, D. P. Jones, S. D. Rhodes, W. S. Weintraub, W. C. Hooper, V. Vaccarino, R. W. Alexander, D. G. Harrison, and A. A. Quyyumi
Endothelial Function and Aminothiol Biomarkers of Oxidative Stress in Healthy Adults
Hypertension,
July 1, 2008;
52(1):
80 - 85.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Jennings, M. F. Muldoon, J. Price, I. C. Christie, and C. C. Meltzer
Cerebrovascular Support for Cognitive Processing in Hypertensive Patients Is Altered by Blood Pressure Treatment
Hypertension,
July 1, 2008;
52(1):
65 - 71.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Balzer, T. Rassaf, C. Heiss, P. Kleinbongard, T. Lauer, M. Merx, N. Heussen, H. B. Gross, C. L. Keen, H. Schroeter, et al.
Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial.
J. Am. Coll. Cardiol.,
June 3, 2008;
51(22):
2141 - 2149.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Muller-Ehmsen, D. Braun, T. Schneider, R. Pfister, N. Worm, K. Wielckens, C. Scheid, P. Frommolt, and M. Flesch
Decreased number of circulating progenitor cells in obesity: beneficial effects of weight reduction
Eur. Heart J.,
June 2, 2008;
29(12):
1560 - 1568.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. E. Pyke, V. Poitras, and M. E. Tschakovsky
Brachial artery flow-mediated dilation during handgrip exercise: evidence for endothelial transduction of the mean shear stimulus
Am J Physiol Heart Circ Physiol,
June 1, 2008;
294(6):
H2669 - H2679.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Vogel
Listening to the Endothelium: A Story of Signal and Noise
J. Am. Coll. Cardiol.,
May 20, 2008;
51(20):
1965 - 1966.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. S. Celermajer
Reliable Endothelial Function Testing: At Our Fingertips?
Circulation,
May 13, 2008;
117(19):
2428 - 2430.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Juonala, M. Kahonen, T. Laitinen, N. Hutri-Kahonen, E. Jokinen, L. Taittonen, M. Pietikainen, H. Helenius, J. S.A. Viikari, and O. T. Raitakari
Effect of age and sex on carotid intima-media thickness, elasticity and brachial endothelial function in healthy adults: The Cardiovascular Risk in Young Finns Study
Eur. Heart J.,
May 1, 2008;
29(9):
1198 - 1206.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Leone and A. Balbarini
Exposure to Passive Smoking: A Test to Predict Endothelial Dysfunction and Atherosclerotic Lesions
Angiology,
May 1, 2008;
59(2):
220 - 223.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Pizzi, L. Manzoli, S. Mancini, and G. M. Costa
Analysis of potential predictors of depression among coronary heart disease risk factors including heart rate variability, markers of inflammation, and endothelial function
Eur. Heart J.,
May 1, 2008;
29(9):
1110 - 1117.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Linden, W. Cai, J. C. He, C. Xue, Z. Li, J. Winston, H. Vlassara, and J. Uribarri
Endothelial Dysfunction in Patients with Chronic Kidney Disease Results from Advanced Glycation End Products (AGE)-Mediated Inhibition of Endothelial Nitric Oxide Synthase through RAGE Activation
Clin. J. Am. Soc. Nephrol.,
May 1, 2008;
3(3):
691 - 698.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Jelic, M. Padeletti, S. M. Kawut, C. Higgins, S. M. Canfield, D. Onat, P. C. Colombo, R. C. Basner, P. Factor, and T. H. LeJemtel
Inflammation, Oxidative Stress, and Repair Capacity of the Vascular Endothelium in Obstructive Sleep Apnea
Circulation,
April 29, 2008;
117(17):
2270 - 2278.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Flammer, I. Sudano, F. Hermann, S. Gay, A. Forster, M. Neidhart, P. Kunzler, F. Enseleit, D. Periat, M. Hermann, et al.
Angiotensin-Converting Enzyme Inhibition Improves Vascular Function in Rheumatoid Arthritis
Circulation,
April 29, 2008;
117(17):
2262 - 2269.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
