|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 2002; 39:210-218 © 2002 by the American College of Cardiology Foundation |
a Duke Clinical Research Institute, Durham, North Carolina, USA
Manuscript received May 25, 2001; revised manuscript received September 10, 2001, accepted October 18, 2001.
* Reprint requests and correspondence: Dr. G. Michael Felker, Duke University Medical Center, Box 31185, Durham, North Carolina, USA 27710.
felke001{at}onyx.dcri.duke.edu
OBJECTIVES: We sought to evaluate the association between the extent of coronary artery disease (CAD) and survival in patients with symptomatic heart failure (HF) and to create the most prognostically powerful clinical definition of ischemic cardiomyopathy.
BACKGROUND: An ischemic etiology of HF is known to be a predictor of adverse outcome; however, there is no uniform definition for ischemic cardiomyopathy.
METHODS: We assessed the clinical history and coronary anatomy of patients with symptomatic HF and ejection fraction 
40% undergoing diagnostic coronary angiography between 1986 and 1999 (n = 1,921). Five classification schemes were tested to identify the most prognostically powerful method for defining the extent of CAD and to develop the best definition of ischemic cardiomyopathy for prognostic purposes.
RESULTS: A more extensive CAD was independently associated with shorter survival. When the various classification schemes were compared, a modified number-of-diseased-vessels classification, in which patients with single-vessel disease and no prior history of revascularization or myocardial infarction (MI) were classified as nonischemic, provided the most prognostic power. A definition of ischemic cardiomyopathy that incorporated this definition had more prognostic power than the traditional definition.
CONCLUSIONS: Angiographically diagnosed ischemic HF is associated with shorter survival than nonischemic HF. A more extensive CAD is independently associated with shorter survival, and patients with single-vessel disease and no history of MI or revascularization should be classified as nonischemic for prognostic purposes. Standardization of the definition of ischemic cardiomyopathy will be useful in the conduct and interpretation of clinical research in HF.
| ||||||||||||||||
This article has been cited by other articles:
|
|
 |
|
  J.-B. le Polain de Waroux, A.-C. Pouleur, C. Goffinet, A. Pasquet, J.-L. Vanoverschelde, and B. L. Gerber Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging Eur. Heart J., September 1, 2008; (2008) ehn381v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ghostine, C. Caussin, M. Habis, Y. Habib, C. Clement, A. Sigal-Cinqualbre, C.-Y. Angel, B. Lancelin, A. Capderou, and J.-F. Paul Non-invasive diagnosis of ischaemic heart failure using 64-slice computed tomography Eur. Heart J., September 1, 2008; 29(17): 2133 - 2140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Niizuma, Y. Iwanaga, T. Yahata, Y. Goto, T. Kita, S. Miyazaki, and H. Nakahama Plasma B-type natriuretic peptide levels reflect the presence and severity of stable coronary artery disease in chronic haemodialysis patients Nephrol. Dial. Transplant., August 31, 2008; (2008) gfn491v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Wu, R. G. Weiss, D. R. Thiemann, K. Kitagawa, A. Schmidt, D. Dalal, S. Lai, D. A. Bluemke, G. Gerstenblith, E. Marban, et al. Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy. J. Am. Coll. Cardiol., June 24, 2008; 51(25): 2414 - 2421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Zintzaras, G. Raman, G. Kitsios, and J. Lau Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphic Variant as a Marker of Coronary Artery Disease: A Meta-analysis Arch Intern Med, May 26, 2008; 168(10): 1077 - 1089. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Sutton, D. R. Crosslin, S. H. Shah, S. C. Nelson, A. Bassil, A. B. Hale, C. Haynes, P. J. Goldschmidt-Clermont, J. M. Vance, D. Seo, et al. Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets Hum. Mol. Genet., May 1, 2008; 17(9): 1318 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Camici, S. K. Prasad, and O. E. Rimoldi Stunning, Hibernation, and Assessment of Myocardial Viability Circulation, January 1, 2008; 117(1): 103 - 114. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Kitsios and E. Zintzaras Genetic Variation associated with Ischemic Heart Failure: A HuGE Review and Meta-Analysis Am. J. Epidemiol., September 15, 2007; 166(6): 619 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Fedoruk, C. G. Tribble, J. A. Kern, B. B. Peeler, and I. L. Kron Predicting Operative Mortality After Surgery for Ischemic Cardiomyopathy Ann. Thorac. Surg., June 1, 2007; 83(6): 2029 - 2035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Andreini, G. Pontone, M. Pepi, G. Ballerini, A. L. Bartorelli, A. Magini, C. Quaglia, E. Nobili, and P. Agostoni Diagnostic Accuracy of Multidetector Computed Tomography Coronary Angiography in Patients With Dilated Cardiomyopathy J. Am. Coll. Cardiol., May 22, 2007; 49(20): 2044 - 2050. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. B. Marcu, A. M. Beek, and A. C. van Rossum Clinical applications of cardiovascular magnetic resonance imaging. Can. Med. Assoc. J., October 10, 2006; 175(8): 911 - 917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gheorghiade, G. Sopko, L. De Luca, E. J. Velazquez, J. D. Parker, P. F. Binkley, Z. Sadowski, K. S. Golba, D. L. Prior, J. L. Rouleau, et al. Navigating the Crossroads of Coronary Artery Disease and Heart Failure Circulation, September 12, 2006; 114(11): 1202 - 1213. [Full Text] [PDF]
|
|
|
|
|
|
F. Ridocci, C. J. Soriano, and J. Estornell Imaging approach to the assessment of cardiomyopathies using delayed enhancement cardiovascular magnetic resonance Eur. Heart J., December 1, 2005; 26(23): 2601 - 2602. [Full Text] [PDF]
|
|
|
|
|
|
H. Mahrholdt, A. Wagner, R. M. Judd, U. Sechtem, and R. J. Kim Delayed enhancement cardiovascular magnetic resonance assessment of non-ischaemic cardiomyopathies Eur. Heart J., August 1, 2005; 26(15): 1461 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Authors/Task Force Members, K. Swedberg, Writing Committee:, J. Cleland, H. Dargie, H. Drexler, F. Follath, M. Komajda, L. Tavazzi, O. A. Smiseth, et al. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology Eur. Heart J., June 1, 2005; 26(11): 1115 - 1140. [Full Text] [PDF]
|
|
|
|
|
|
C. J. Soriano, F. Ridocci, J. Estornell, J. Jimenez, V. Martinez, and J. A. De Velasco Noninvasive diagnosis of coronary artery disease in patients with heart failure and systolic dysfunction of uncertain etiology, using late gadolinium-enhanced cardiovascular magnetic resonance J. Am. Coll. Cardiol., March 1, 2005; 45(5): 743 - 748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Kittleson, S. Q. Ye, R. A. Irizarry, K. M. Minhas, G. Edness, J. V. Conte, G. Parmigiani, L. W. Miller, Y. Chen, J. L. Hall, et al. Identification of a Gene Expression Profile That Differentiates Between Ischemic and Nonischemic Cardiomyopathy Circulation, November 30, 2004; 110(22): 3444 - 3451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gattenlohner, C. Waller, G. Ertl, B.-D. Bultmann, H.-K. Muller-Hermelink, and A. Marx NCAM(CD56) and RUNX1(AML1) Are Up-Regulated in Human Ischemic Cardiomyopathy and a Rat Model of Chronic Cardiac Ischemia Am. J. Pathol., September 1, 2003; 163(3): 1081 - 1090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. deFilippi, S. Wasserman, S. Rosanio, E. Tiblier, H. Sperger, M. Tocchi, R. Christenson, B. Uretsky, M. Smiley, J. Gold, et al. Cardiac Troponin T and C-Reactive Protein for Predicting Prognosis, Coronary Atherosclerosis, and Cardiomyopathy in Patients Undergoing Long-term Hemodialysis JAMA, July 16, 2003; 290(3): 353 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.A. McCrohon, J.C.C. Moon, S.K. Prasad, W.J. McKenna, C.H. Lorenz, A.J.S. Coats, and D.J. Pennell Differentiation of Heart Failure Related to Dilated Cardiomyopathy and Coronary Artery Disease Using Gadolinium-Enhanced Cardiovascular Magnetic Resonance Circulation, July 8, 2003; 108(1): 54 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Kleikamp, A. Maleszka, N. Reiss, B. Stuttgen, and R. Korfer Determinants of mid- and long-term results in patients after surgical revascularization for ischemic cardiomyopathy Ann. Thorac. Surg., May 1, 2003; 75(5): 1406 - 1412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Felker, R. L. Benza, A. B. Chandler, J. D. Leimberger, M. S. Cuffe, R. M. Califf, M. Gheorghiade, C. M. O'Connor, and OPTIME-CHF Investigators Heart failure etiology and response tomilrinone in decompensated heart failure: Results from the OPTIME-CHF study J. Am. Coll. Cardiol., March 19, 2003; 41(6): 997 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tenenbaum, E. Z. Fisman, and M. Motro Toward a redefinition of ischemic cardiomyopathy: is it an indivisible entity? J. Am. Coll. Cardiol., July 3, 2002; 40(1): 205 - 206. [Full Text] [PDF]
|
|
|
|
|
|
G. M. Felker, L. K. Shaw, and C. M. O'Connor Reply J. Am. Coll. Cardiol., July 3, 2002; 40(1): 206 - 206. [Full Text] [PDF]
|
|
|
|
|
|
T. O. Cheng Ischemic cardiomyopathy: a historical note J. Am. Coll. Cardiol., May 1, 2002; 39(9): 1564 - 1565. [Full Text] [PDF]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
