|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 2002; 39:2059-2068 © 2002 by the American College of Cardiology Foundation |
,*
* Clinical Trials and Evidence-Based Medicine Unit and Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
Cardiology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Manuscript received September 18, 2001; revised manuscript received February 25, 2002, accepted March 14, 2002.
* Reprint requests and correspondence: Dr. Peter G. Danias, Division of Cardiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
pdanias{at}caregroup.harvard.edu
OBJECTIVES: The purpose of this study was to evaluate the accuracy of electrocardiogram (ECG)-gated single-photon emission computed tomography (SPECT) for assessment of left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV) and ejection fraction (EF) compared with the gold standard of cardiac magnetic resonance imaging (MRI).
BACKGROUND: Several comparisons of ECG-gated SPECT with cardiac MRI have been performed for evaluation of LV volumes and EF, but each has considered few subjects, thus leaving uncertainty about the frequency of discrepancies between the two methods.
METHODS: We performed a meta-analysis of data on 164 subjects from nine studies comparing ECG-gated SPECT versus cardiac MRI. Data were pooled in correlation and regression analyses relating ECG-gated SPECT and cardiac MRI measurements. The frequency of discrepancies of at least 30 ml in EDV, 20 ml in ESV and 5% or 10% in EF and concordance for EF 
40% versus >40% were determined.
RESULTS: There was an overall excellent correlation between ECG-gated SPECT and cardiac MRI for EDV (r = 0.89), ESV (r = 0.92) and EF (r = 0.87). However, rates of discrepancies for individual subjects were considerable (37% [95% confidence interval {CI}, 26% to 50%] for at least 30 ml in EDV; 35% [95% CI, 23% to 49%] for at least 20 ml in ESV; 52% [95% CI, 37% to 63%] for at least 5% in EF; and 23% [95% CI, 11% to 42%] for at least 10% in EF). The misclassification rate for the 40% EF cutoff was 11%.
CONCLUSIONS: Electrocardiogram-gated SPECT measurements of EDV, ESV and EF show high correlation with cardiac MRI measurements, but substantial errors may occur in individual patients. Electrocardiogram-gated SPECT offers useful functional information, but cardiac MRI should be used when accurate measurement is required.
| ||||||||||||||||||||||
This article has been cited by other articles:
|
|
 |
|
  D. Knollmann, O. H. Winz, P. T. Meyer, M. Raptis, T. Krohn, K.-C. Koch, and W. M. Schaefer Gated Myocardial Perfusion SPECT: Algorithm-Specific Influence of Reorientation on Calculation of Left Ventricular Volumes and Ejection Fraction J. Nucl. Med., October 1, 2008; 49(10): 1636 - 1642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Galema, M. L. Geleijnse, S.-C. Yap, R. T. van Domburg, E. Biagini, W. B. Vletter, and F. J. Ten Cate Assessment of left ventricular ejection fraction after myocardial infarction using contrast echocardiography Eur J Echocardiogr, March 1, 2008; 9(2): 250 - 254. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Henneman, J. D. Schuijf, E. E. van der Wall, and J. J. Bax Non-invasive anatomical and functional imaging for the detection of coronary artery disease Br. Med. Bull., January 5, 2007; (2007) ldl014v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J D Schuijf, L J Shaw, W Wijns, H J Lamb, D Poldermans, A de Roos, E E van der Wall, and J J Bax Cardiac imaging in coronary artery disease: differing modalities Heart, August 1, 2005; 91(8): 1110 - 1117. [Full Text] [PDF]
|
|
|
|
|
|
C. Akincioglu, D. S. Berman, H. Nishina, P. B. Kavanagh, P. J. Slomka, A. Abidov, S. Hayes, J. D. Friedman, and G. Germano Assessment of Diastolic Function Using 16-Frame 99mTc-Sestamibi Gated Myocardial Perfusion SPECT: Normal Values J. Nucl. Med., July 1, 2005; 46(7): 1102 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schafers, J. Stypmann, M. J. Wilhelm, L. Stegger, P. Kies, S. Hermann, C. Schmidt, G. Breithardt, H. H. Scheld, and O. Schober Functional Changes After Partial Left Ventriculectomy and Mitral Valve Repair Assessed by Gated Perfusion SPECT J. Nucl. Med., October 1, 2004; 45(10): 1605 - 1610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Go, M. R. Bhatt, and R. C. Hendel The Diagnostic and Prognostic Value of ECG-Gated SPECT Myocardial Perfusion Imaging J. Nucl. Med., May 1, 2004; 45(5): 912 - 921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H.J.A. Slart, J. J. Bax, R. M. de Jong, J. de Boer, H. J. Lamb, P. H. Mook, A. T.M. Willemsen, W. Vaalburg, D. J. van Veldhuisen, and P. L. Jager Comparison of Gated PET with MRI for Evaluation of Left Ventricular Function in Patients with Coronary Artery Disease J. Nucl. Med., February 1, 2004; 45(2): 176 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Schaefer, C. S.A. Lipke, B. Nowak, H.-J. Kaiser, P. Reinartz, A. Buecker, G. A. Krombach, U. Buell, and H. P. Kuhl Validation of QGS and 4D-MSPECT for Quantification of Left Ventricular Volumes and Ejection Fraction from Gated 18F-FDG PET: Comparison with Cardiac MRI J. Nucl. Med., January 1, 2004; 45(1): 74 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. C. Aepfelbacher, S. B. Yeon, K. K. L. Ho, J. A. Parker, and P. G. Danias ECG-Gated 99mTc Single-Photon Emission CT for Assessment of Right Ventricular Structure and Function: Is the Information Provided Similar to Echocardiography? Chest, July 1, 2003; 124(1): 227 - 232. [Abstract] [Full Text] [PDF]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
