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J Am Coll Cardiol, 2002; 39:1845-1851 © 2002 by the American College of Cardiology Foundation |
* Department of Cardiovascular Sciences, General Hospital "S. Maria Della Misericordia," Udine, Italy
Manuscript received September 17, 2001; revised manuscript received March 4, 2002, accepted March 6, 2002.
* Reprint requests and correspondence: Dr. Sandro Gelsomino, U. O. Cardiotoracica, Azienda Ospedaliera S. Maria della Misericordia, Piazzale S. Maria Della Misericordia 11.33100 Udine, Italy.
sandrogelsomino{at}virgilio.it
OBJECTIVES: This study evaluated the occurrence of prosthesis-patient mismatch (PPM) after Cryolife OBrien (CLOB) suprannular stentless valve replacement in patients with a small aortic root and its repercussions on the patients hemodynamic status and left ventricular mass regression.
BACKGROUND: The correct management of the small aortic annulus is still controversial. Small aortic prostheses can lead to a PPM, which results in high gradients with important repercussions on the hemodynamic status.
METHODS: Seventy-two patients (mean age: 72.5 ± 6.2 years, 73.6% women) with a small aortic root (
21 mm intraoperatively measured aortic annulus) had a CLOB valve implanted in the aortic position between November 1993 and July 2001 at our institution. Mean prosthesis size was 22.0 ± 0.8 mm. Patients underwent echocardiography preoperatively, at discharge, six months, one year and yearly thereafter.
RESULTS: The incidence of PPM at discharge was 22.2% (16/72); 18.7% were severe (effective orifice area index [EOAI]
0.65 cm/m2), 43.7% were moderate (EOAI = 0.66 to 0.75 cm/m2) and 37.6% were mild (0.76 to 0.85 cm/m2). At multivariable analysis, gender (p < 0.001), age (p = 0.015), body surface area (p < 0.001) and patients annulus index (p < 0.001) were significant factors influencing the occurrence of "transient" PPM. At one year the incidence of PPM was 0%.
CONCLUSIONS: Suprannular CLOB valve yielded excellent hemodynamic results in patients with small aortic roots. This study demonstrates that PPM can be completely avoided when using the CLOB valve. The superior hemodynamics of this stentless valve are likely to be related to its suprannular design.
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