|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 2002; 39:49-56 © 2002 by the American College of Cardiology Foundation |
||||
* Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts, USA
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
|| Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Manuscript received March 19, 2001; revised manuscript received September 10, 2001, accepted September 10, 2001.
* Reprint requests and correspondence: Dr. Simin Liu, Division of Preventive Medicine, Brigham and Women’s Hospital, 900 Commonwealth Avenue East, Boston, Massachusetts 02215, USA.
simin.liu{at}channing.harvard.edu
OBJECTIVES: This study was designed to examine the hypothesis that higher intake of dietary fiber is inversely related to the risk of cardiovascular disease (CVD) and myocardial infarction (MI) in a large prospective cohort of women.
BACKGROUND: Although dietary fiber has been suggested to reduce the risk of coronary disease, few prospective studies have examined the association between the types and amounts of dietary fiber and CVD risk, particularly among women.
METHODS: In 1993, we used a semi-quantitative food frequency questionnaire to assess dietary fiber intake among 39,876 female health professionals with no previous history of CVD or cancer. Women were subsequently followed for an average of six years for incidence of nonfatal MI, stroke, percutaneous transluminal coronary angioplasty, coronary artery bypass graft or death due to CVD confirmed by medical records or death certificates.
RESULTS: During 230,006 person-years of follow-up, 570 incident cases of CVD were documented, including 177 MIs. After adjustment for age and randomized treatment status, a significant inverse association was observed between dietary fiber intake and CVD risk. Comparing the highest quintile of fiber intake (median: 26.3 g/day) with the lowest quintile (median: 12.5 g/day), the relative risks (RR) were 0.65 (95% confidence interval [CI]: 0.51, 0.84) for total CVD and 0.46 (95% CI: 0.30, 0.72) for MI. Additional adjustment for CVD risk factors reduced the RRs to 0.79 (95% CI: 0.58, 1.09) for total CVD and 0.68 (95% CI: 0.36, 1.22) for MI. The inverse trends across categories generally remained, although they were no longer statistically significant. Inverse relations were observed between both soluble and insoluble fiber and risk of CVD and MI, and among those who had never smoked and those with body mass index <25.
CONCLUSIONS: A higher intake of dietary fiber was associated with a lower risk of CVD and MI, although the association was not statistically significant after further adjusting for multiple confounding factors. Nevertheless, these prospective data generally support current dietary recommendations to increase the consumption of fiber-rich whole grains and fruits and vegetables as a primary preventive measure against CVD.
| ||||||||||||||||||||
This article has been cited by other articles:
|
|
 |
|
  D. E. King, A. G. Mainous III, B. M. Egan, R. F. Woolson, and M. E. Geesey Effect of Psyllium Fiber Supplementation on C-Reactive Protein: The Trial to Reduce Inflammatory Markers (TRIM) Ann. Fam. Med, March 1, 2008; 6(2): 100 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Andon and J. W. Anderson State of the Art Reviews: The Oatmeal-Cholesterol Connection: 10 Years Later American Journal of Lifestyle Medicine, February 1, 2008; 2(1): 51 - 57. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Ma, J. A Griffith, L. Chasan-Taber, B. C Olendzki, E. Jackson, E. J Stanek III, W. Li, S. L Pagoto, A. R Hafner, and I. S Ockene Association between dietary fiber and serum C-reactive protein. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 760 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lairon, N. Arnault, S. Bertrais, R. Planells, E. Clero, S. Hercberg, and M.-C. Boutron-Ruault Dietary fiber intake and risk factors for cardiovascular disease in French adults Am. J. Clinical Nutrition, December 1, 2005; 82(6): 1185 - 1194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Liu, Y. Song, E. S. Ford, J. E. Manson, J. E. Buring, and P. M. Ridker Dietary Calcium, Vitamin D, and the Prevalence of Metabolic Syndrome in Middle-Aged and Older U.S. Women Diabetes Care, December 1, 2005; 28(12): 2926 - 2932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Kabagambe, A. Baylin, E. Ruiz-Narvarez, X. Siles, and H. Campos Decreased Consumption of Dried Mature Beans Is Positively Associated with Urbanization and Nonfatal Acute Myocardial Infarction J. Nutr., July 1, 2005; 135(7): 1770 - 1775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Song, P. M. Ridker, J. E. Manson, N. R. Cook, J. E. Buring, and S. Liu Magnesium Intake, C-Reactive Protein, and the Prevalence of Metabolic Syndrome in Middle-Aged and Older U.S. Women Diabetes Care, June 1, 2005; 28(6): 1438 - 1444. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. Roberts and R. J. Barnard Effects of exercise and diet on chronic disease J Appl Physiol, January 1, 2005; 98(1): 3 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Holmes, S. Liu, S. E. Hankinson, G. A. Colditz, D. J. Hunter, and W. C. Willett Dietary Carbohydrates, Fiber, and Breast Cancer Risk Am. J. Epidemiol., April 15, 2004; 159(8): 732 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Pereira, E. O'Reilly, K. Augustsson, G. E. Fraser, U. Goldbourt, B. L. Heitmann, G. Hallmans, P. Knekt, S. Liu, P. Pietinen, et al. Dietary Fiber and Risk of Coronary Heart Disease: A Pooled Analysis of Cohort Studies Arch Intern Med, February 23, 2004; 164(4): 370 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wu, K. M Dwyer, Z. Fan, A. Shircore, J. Fan, and J. H Dwyer Dietary fiber and progression of atherosclerosis: the Los Angeles Atherosclerosis Study Am. J. Clinical Nutrition, December 1, 2003; 78(6): 1085 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Bazzano, J. He, L. G. Ogden, C. M. Loria, and P. K. Whelton Dietary Fiber Intake and Reduced Risk of Coronary Heart Disease in US Men and Women: The National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study Arch Intern Med, September 8, 2003; 163(16): 1897 - 1904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mozaffarian, S. K. Kumanyika, R. N. Lemaitre, J. L. Olson, G. L. Burke, and D. S. Siscovick Cereal, Fruit, and Vegetable Fiber Intake and the Risk of Cardiovascular Disease in Elderly Individuals JAMA, April 2, 2003; 289(13): 1659 - 1666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Liu, H. D Sesso, J. E Manson, W. C Willett, and J. E Buring Is intake of breakfast cereals related to total and cause-specific mortality in men? Am. J. Clinical Nutrition, March 1, 2003; 77(3): 594 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Yancy Jr, E. C. Westman, P. A. French, and R. M. Califf Diets and Clinical Coronary Events: The Truth Is Out There Circulation, January 7, 2003; 107(1): 10 - 16. [Full Text] [PDF]
|
|
|
|
|
|
F. B. Hu and W. C. Willett Optimal Diets for Prevention of Coronary Heart Disease JAMA, November 27, 2002; 288(20): 2569 - 2578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. D. Rosamond Dietary fiber and prevention of cardiovascular disease J. Am. Coll. Cardiol., January 2, 2002; 39(1): 57 - 59. [Full Text] [PDF]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
