CLINICAL STUDY
Diastolic heart failure: neglected or misdiagnosed?
Prithwish Banerjee, MBBS, MD, MRCP*,*,
Tumpa Banerjee, MBBS, MRCP*,
Aleem Khand, MBCHB, MRCP*,
Andrew L. Clark, MA, MD, MRCP* and
John G. F. Cleland, MD, FRCP, FESC, FACC*
* Department of Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull, United Kingdom
Manuscript received June 26, 2001;
revised manuscript received September 12, 2001,
accepted September 20, 2001.
* Reprint requests and correspondence: Dr. Prithwish Banerjee, Department of Cardiology, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, United Kingdom.
pbanerjee{at}ukonline.co.uk
Recent epidemiological studies suggest that 30% to 50% of patients with heart failure (HF) have preserved left ventricular (LV) systolic function. These patients, often presumed to have diastolic heart failure (DHF), appear to have lower short-term but similar long-term mortality when compared to patients with HF and LV systolic dysfunction. Rates of recurrent hospitalization and costs of care appear similar in the two groups of patients. Therefore, DHF may contribute significantly to the burden of disease caused by HF. Exertional breathlessness, the principal symptom of HF, has many causes, including obesity, pulmonary disease and myocardial ischemia. A diagnosis of DHF by exclusion, based on symptoms in the absence of important LV systolic dysfunction or major valve disease, is unsatisfactory. Unfortunately, as yet, no reliable definition with which to make a positive diagnosis of DHF has been agreed on, frequently rendering this diagnosis uncertain. Echocardiography has several limitations, whereas hemodynamic confirmation of DHF by cardiac catheterization is potentially complex and not practically feasible for many patients. Treatment of DHF remains empirical and unsatifasctory because of the lack of large-scale randomized controlled trials in this area. Currently, three large outcome studies on DHF are in progress along with other smaller trials. These should start to provide some of the answers we need to diagnose and effectively treat DHF.
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Abbreviations and Acronyms
| | CHF | | congestive heart failure | | DHF | | diastolic heart failure | | EF | | ejection fraction | | HF | | heart failure | | LV | | left ventricular |
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