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J Am Coll Cardiol, 2001; 38:969-976 © 2001 by the American College of Cardiology Foundation |
* Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, Massachusetts, USA
Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Division of Cardiology, University of California–San Francisco, San Francisco, California, USA
Department of Pathology, University of Vermont College of Medicine, Colchester, Vermont, USA
Manuscript received December 27, 2000; revised manuscript received May 3, 2001, accepted June 25, 2001.
Reprint requests and correspondence: Dr. Daniel H. Solomon, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, 221 Longwood Avenue, Suite 341, Boston, Massachusetts 02115
dsolomon{at}rics.bwh.harvard.edu
OBJECTIVES
This study was designed to determine whether patient characteristics collected at presentation can identify which patients benefit from immediate coronary angiography and revascularization.
BACKGROUND
Risk stratification may offer a method for identifying which patients with unstable angina or non–Q-wave myocardial infarction (NQMI) are likeliest to benefit from invasive management strategies.
METHODS
The analysis was based on data from a randomized controlled trial that enrolled 1,473 patients presenting with unstable angina or NQMI who were randomly assigned to an early invasive or early conservative (medical) management strategy. We constructed a risk-stratification score for each patient based on adjusted odds ratios for clinical variables likely to predict adverse outcomes. We stratified all trial subjects by their risk scores and studied the rates of death or myocardial infarction (MI) of the early invasive management strategy in each stratum.
RESULTS
The final multivariate model included older age, ST segment depression on presentation, history of complicated angina before presentation, and elevation in baseline creatine kinase-MB fraction. Although patients with a higher risk score had an increased rate of death or MI within 42 days and 365 days (p < 0.001) in both management strategies, early invasive management for patients in the high and very high risk categories was associated with a lower rate of death or MI within 42 days compared with conservative management. No such benefit was seen in patients in the larger group of patients in the very low, low or moderate risk categories (p = 0.03 for the interaction between risk category and management assignment).
CONCLUSIONS
Risk stratification may be an effective method for identifying those patients with unstable angina or NQMI most likely to benefit from early invasive management. Selective use of early invasive management can have a substantial impact in reducing morbidity and mortality in higher risk patients, but may not be warranted in lower risk patients.
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