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CLINICAL STUDY: ELECTROPHYSIOLOGY

Prevalence and mortality of the Brugada-type electrocardiogram in one city in Japan

^a Cardiovascular Division, Department of Medicine II, Kansai Medical University, Osaka, Japan

Manuscript received January 5, 2001; revised manuscript received April 5, 2001, accepted May 17, 2001.

Reprint requests and correspondence: Dr. Yoko Miyasaka, Cardiovascular Division, Department of Medicine II, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-city, Osaka, Japan, 570-8507
miyasaka{at}takii.kmu.ac.jp

OBJECTIVES

We sought to study the prevalence and mortality of subjects exhibiting the Brugada-type electrocardiogram (ECG) in a community-based population in Japan.

BACKGROUND

The Brugada syndrome has been associated with sudden death in subjects without structural heart disease. Hospital-based studies showed 11% to 38% annual fatal arrhythmic events in patients with the Brugada syndrome.

METHODS

Prevalence and mortality of the Brugada-type ECG were studied in subjects who had ECGs during a health examination in Moriguchi, Osaka, Japan. Information about death and relocation from Moriguchi city was obtained prospectively.

RESULTS

The Brugada-type ECG was found in 98 of 13,929 study subjects (0.70%, 95% confidence interval [CI]: 0.57% to 0.86%). The typical coved-type with an rsR' pattern in V₁ lead ("typical" Brugada-type) was found in 0.12% of subjects (95% CI: 0.07% to 0.20%). The prevalence for male subjects with the Brugada-type ECG (81%) was significantly higher than it was for those without (26%, p < 0.0001). In male subjects, the Brugada-type ECG was found in 2.14% (95% CI: 1.70% to 2.66%), and the "typical" Brugada-type was found in 0.38% (95% CI: 0.21% to 0.64%). After 2.6 ± 0.3 years of follow-up, there was 1 death (1.0%, 95% CI: 0.03% to 5.6%) of a subject with the Brugada-type ECG, whereas there were 139 deaths (1.0%, 95% CI: 0.85% to 1.2%) of those without the Brugada-type ECG (p = 0.9943, log-rank test).

CONCLUSIONS

A substantial number of the Brugada-type ECG were observed in subjects in a community-based population in Japan, especially in men. The total mortality of subjects with the Brugada-type ECG did not differ from the mortality of those without the Brugada-type ECG in a community-based population.

Abbreviations and Acronyms   CI = confidence interval   ECG = electrocardiogram

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