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CLINICAL STUDY: INTERVENTIONAL CARDIOLOGY

Treatment of diffuse in-stent restenosis with rotational atherectomy followed by radiation therapy with a rhenium-188–mercaptoacetyltriglycine-filled balloon

Seong-Wook Park, MD, PhD, FACC^*, Myeong-Ki Hong, MD, PhD^*, Dae Hyuk Moon, MD, PhD, Seung Jun Oh, PhD, Cheol Whan Lee, MD^*, Jae-Joong Kim, MD, PhD^* and Seung-Jung Park, MD, PhD, FACC^*

^* Department of Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
Department of Nuclear Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

Manuscript received October 31, 2000; revised manuscript received May 14, 2001, accepted June 4, 2001.

Reprint requests and correspondence: Dr. Seong-Wook Park, Departments of Medicine, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnap-dong, Songpa-gu, Seoul, 138-736, Korea
swpark{at}www.amc.seoul.kr

OBJECTIVES

This study was done to evaluate the feasibility and efficacy of beta-radiation therapy with a rhenium-188–mercaptoacetyltriglycine (¹⁸⁸Re-MAG₃)-filled balloon after rotational atherectomy for diffuse in-stent restenosis (ISR).

BACKGROUND

Rotational atherectomy has been shown to be safe and efficient for the treatment of ISR, but the recurrence rate is still high. Intracoronary beta-irradiation after rotational atherectomy may be a reasonable approach to prevent recurrent ISR.

METHODS

Fifty consecutive patients with diffuse ISR (length >10 mm) in native coronary arteries underwent rotational atherectomy and adjunctive balloon angioplasty, followed by beta-irradiation using a ¹⁸⁸Re-MAG₃–filled balloon catheter. The radiation dose was 15 Gy at a depth of 1.0 mm into the vessel wall.

RESULTS

The mean lengths of the lesion and irradiated segment were 25.6 ± 12.7 mm and 37.6 ± 11.2 mm, respectively. Radiation was delivered successfully to all patients, with a mean irradiation time of 201.8 ± 61.7 s. No adverse event, including myocardial infarction, death or stent thrombosis, occurred during the follow-up period (mean 10.3 ± 3.7 months), and nontarget vessel revascularization was needed in one patient. The six-month binary angiographic restenosis rate was 10.4%, and the loss index was 0.17 ± 0.31.

CONCLUSIONS

Beta-irradiation using a ¹⁸⁸Re-MAG₃–filled balloon after rotational atherectomy is safe and feasible in patients with diffuse ISR, and it may improve their clinical and angiographic outcomes. Further prospective, randomized trials are warranted to evaluate the synergistic effect of debulking and irradiation in patients with diffuse ISR.

Abbreviations and Acronyms   CSA = cross-sectional area   EEM = external elastic membrane   IH = intimal hyperplasia   ISR = in-stent restenosis   IVUS = intravascular ultrasound   MACE = major adverse cardiac events   MAG3 = mercaptoacetyltriglycine   MI = myocardial infarction   PTCA = percutaneous transluminal coronary angioplasty   QCA = quantitative coronary angiography   188Re = rhenium-188

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